2005进入bobapp官方下载 工作至今，先后任助理研究员、副研究员，主要从事创新药物研发、有机合成等方面的工作。近年来，主持或参与科研项目共10余项，其中主持国家自然青年基金项目1项，药物所基本科研业务费3项，参与的项目包括国家科技重大专项2项，中国医学科学院医学与健康科技创新工程1项，国自然面上项目3项等。近年来发表SCI论文10余篇,申请发明专利9项，其中两项获得授权。

药物分子设计与合成 针对肿瘤、糖尿病和精神神经系统等疾病领域的生物大分子靶标，设计合成新结构的小分子化学实体，寻找干预疾病信号传导通路的先导结构，经结构修饰和优化，发现具有潜在治疗作用的侯选药物。

1. Discovery of N-arylsulfonyl-indole-2-carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors― Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis, Jie Zhou#, Jianbo Bie#, Xiaoyu Wang#, Quan Liu, Rongcui Li, Hualong Chen, Jinping Hu, Hui Cao, Wenming Ji, Yan Li, Shuainan Liu*, Zhufang Shen*, Bailing Xu*, Journal of Medicinal Chemistry, 2020,10307-10329

2. Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP1/2 inhibitors: design,synthesis and their antitumor activity, Zhou jie#, Ji Ming#, Yao Haiping, Cao Ran, Zhao Hailong, Wang Xiaoyu, Chen Xiaoguang*, Xu Bailing*, Organic & Biomolecilar Chemistry, 2018, 16(17):3189-3202

3.Discovery of 2-substituted 1H-benzo[d]imidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity, Zhou jie#, Ji Ming#, Zhu Zhixiang, Cao Ran, Chen Xiaoguang*, Xu Bailing*, European Journal of Medicinal Chemistry, 2017,132: 26-41.

4. 3-氨基苯甲酰胺衍生物PARP-1抑制剂的设计、合成及活性评价，周洁，朱枝祥，季鸣，曹冉，陈晓光，徐柏玲，中国药物化学杂志，2016, 26, 165-174.

5. Synthesis and biological evaluation of novel quinoxalinone-based HIV-1 reverse transcriptase inhibitors, Jie Zhou,# Mingyu Ba#, Bo Wang, Haibo Zhou, Jianbo Bie, Decai Fu, Yingli Cao, Bailing Xu*, Ying Guo*, Med. Chem. Commun., 2014, 5, 441-444

6. Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4, Jie Zhou#, Jing Jin# , Yi Zhang, Yuwen, Yin, Xiaoguang Chen*, Bailing Xu*, European Journal of Medicinal Chemistry, 2013, 68, 222-232.

7. 周 洁, 朱枝祥, 陈晓光, 徐柏玲. 氮杂吲哚类PARP-1抑制剂的合成及活性评价，药学学报，2013, 48, 1792-1799.

8. Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors, Hailong Zhao#, Ming Ji#, Guonan Cui, Jie zhou, Fangfang Lai, Xiaoguang Chen*, Bailing Xu*, Bioorgnic Medicinal Chemistry 2017, 25(15): 4045-4054.

9. Poly (ADP-ribose) polymerases inhibitor, Zj6413, as apotential therapeuticagent against breast cancer, Biochemical Pharmacology, QinZhou, Ming Ji, Jie zhou, JingJin, Nina Xue, Ju Chen, Bailing xu, Xiaoguang chen , 2016, 107, 29-40.

10. Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors, Haiping Yao#, Ming Ji# , Zhixiang Zhu, Jie zhou, Ran Cao, Xiaoguang Chen*, Bailing Xu*, Bioorgnic Medicinal Chemistry 2015, 23, 681-693.

11. Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase, Jianbo Bie, Shuainan Liu, Jie Zhou, Bailing Xu*, Zhufang Shen*, Bioorgnic Medicinal Chemistry, 2014, 22, 1850-1862.

1. 含有哌嗪酮的喹唑啉酮类PARP-1/2抑制剂及其制备方法、药物组合物和用途；徐柏玲、陈晓光、周洁、季鸣、姚海平、周秦；专利授权日：2020-5-7，专利号：ZL201610108263.3.

2. N-酰基磺酰胺类FBPase抑制剂、其制备方法、药物组合物及用途; 徐柏玲、申竹芳、别建波、穆永钊、刘率男、周洁、李彩娜、曹冉、环弈、孙淑娟，专利授权日：2020-10-9，专利号：ZL 2016 1 0105864.9.