张东峰：博士，副研究员，硕士研究生导师 主要研究领域包括抗结核与抗肿瘤药物研发、生物活性天然产物的合成及结构改造、有机合成方法学等。作为课题负责人主持了“重大新药创制”国家科技重大专项子课题、国家自然科学基金青年基金、中国医学科学院医学与健康科技创新工程和中央公益性科研院所基本科研业务费等项目。作为主要研究人员还参加了药物所与全球结核病药物研发联盟的国际合作项目，国家“十一五”、“十二五”重大新药创制专项，北京市科委以及与企业合作的开发项目等多项课题。目前已发表研究论文29篇，申请发明专利21项，其中获授权专利9项。2011年和2013年分别获得中国药学大会暨第十一届中国药师周优秀论文三等奖和第十一届全国医药卫生青年科技论坛优秀论文三等奖。2018年获得bobapp官方下载 “梁周黄于刘青年科技奖”二等奖。

1、基于结构或受体的药物分子设计、合成与生物活性研究
2、新药开发及合成工艺研究

1. Hongyi Zhao,# Shengnan Li,# Shihao Cheng, Ziyun Lin, Dongfeng Zhang* and Haihong Huang*, A mild and metal-free synthesis of chiral 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazines, Tetrahedron, 2021, 10.1016/j.tet.2021.132304 (IF=2.233)
2. Xiao Wang,# Wenting Zhao,# Bin Wang, Wei Ding, Hao Guo, Hongyi Zhao, Jianzhou Meng, Sihan Liu, Yu Lu, Yishuang Liu*, Dongfeng Zhang*. Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads. Bioorganic Chemistry, 2021, 10.1016/j.bioorg.2021.105110 (IF=4.831)
3. Dongfeng Zhang,# Peng Li,# Yongxin Gao, Yaoyao Song, Yaqin Zhu, Hong Su, Beibei Yang, Li Li, Gang Li, Ningbo Gong, Yang Lu, Huanjie Shao,* Chunrong Yu,* and Haihong Huang*. Discovery of a Candidate Containing an (S) 3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro 1H inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I Resistant Mutant for the Treatment of Chronic Myeloid Leukemia. Journal of Medicinal Chemistry, 2021, 64(11), 7434−7452 (IF=6.205)
4. Yongqi Wu, Bin Wang, Haijia Lu, Hongyi Zhao, Beibei Yang, Li Li, Yu Lu, Dongfeng Zhang*, Ning Sun*, Haihong Huang*. Identification of novel tricyclic benzo[1,3]oxazinyloxazolidinones as potent antibacterial agents with excellent pharmacokinetic profiles against drug-resistant pathogens. Journal of Medicinal Chemistry, 2021, 64(6), 3234−3248 (IF=6.205)
5. Hongyi Zhao, Bin Wang, Lei Fu, Gang Li, Haijia Lu, Yuke Liu, Li Sheng, Yan Li, Baoxi Zhang, Yang Lu, Chen Ma, Haihong Huang*, Dongfeng Zhang*, and Yu Lu*. Discovery of a conformationally constrained oxazolidinone with improved safety and efficacy profiles for the treatment of multidrug-resistant tuberculosis. Journal of Medicinal Chemistry, 2020, 63(17), 9316-9339 (IF=6.205)
6. Hongyi Zhao, Wenting Zhao, Shihao Cheng, Haijia Lu, Dongfeng Zhang*, and Haihong Huang*, Efficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones, RSC Advances, 2020, 10, 24037-24044 (IF=3.049)
7. Wenting Zhao, Bin Wang, Yuke Liu, Lei Fu, Li Sheng, Hongyi Zhao, Yu Lu, Dongfeng Zhang*, Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis. European Journal of Medicinal Chemistry, 2020, 189, 112075 (IF=5.572)
8. Yong-Qi Wu, Hai-Jia Lu, Wen-Ting Zhao, Hong-Yi Zhao, Zi-Yun Lin, Dong-Feng Zhang*, and Hai-Hong Huang*, A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide, Synthetic Communications, 2020, 50(6), 813-822 (IF=1.796)
9. Keli Cui, Meng Gao, Hongyi Zhao, Dongfeng Zhang*, Hong Yan* and Haihong Huang*. An Efficient Synthesis of Aryl-Substituted Pyrroles by the Suzuki–Miyaura Coupling Reaction of SEM-Protected Pyrroles. Molecules, 2019, 24(8), 1594 (IF=3.098)
10. Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao, Dongni Chen, Meng Gao, Qinglin Wang, Bin Wang, Haihong Huang*, Yongjun Lu*, Yu Lu*. Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold. Bioorganic Chemistry, 2019, 85, 229-239 (IF=4.831)
11. Meng Gao, Wenting Zhao, Hongyi Zhao, Ziyun Lin, Dongfeng Zhang* and Haihong Huang*. An efficient and facile access to highly functionalized pyrrole derivatives. Beilstein Journal of Organic Chemistry, 2018, 14, 884-890 (IF=2.597)
12. Hongyi Zhao, Yu Lu, Li Sheng, Zishuo Yuan, Bin Wang, Weiping Wang, Yan Li, Chen Ma, Xiaoliang Wang, Dongfeng Zhang*, and Haihong Huang*. Discovery of fluorine-containing benzoxazinyl-oxazolidinones for the treatment of multidrug resistant tuberculosis. ACS Medicinal Chemistry Letters, 2017, 8 (5), 533-537 (IF=3.407)
13. Dongfeng Zhang, Peng Li, Ziyun Lin, Haihong Huang*. An improved synthesis of (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane. Chinese Chemical Letters, 2014, 45(3), 479-481 (IF=1.822)
14. Dongfeng Zhang, Peng Li, Ziyun Lin, Haihong Huang*. An efficient and convenient protocol for synthesis of 1,1-difluoro-6-nitro-2,3-dihydro-1H-indene derivatives. Synthesis, 2014, 46(5), 613-620 (IF=2.664)
15. Dongfeng Zhang, Yang Liu, Chunlin Zhang, Hao Zhang, Bin Wang, Jian Xu, Lei Fu, Dali Yin, Christopher B. Cooper, Zhenkun Ma*, Yu Lu*, and Haihong Huang*. Synthesis and biological evaluation of novel 2-methoxypyridylamino-substituted riminophenazine derivatives as antituberculosis agents. Molecules, 2014, 19(4), 4380-4394 (IF=2.581)
16. Dongfeng Zhang#, Yu Lu#, Kai Liu, Binna Liu, Jingbin Wang, Gang Zhang, Hao Zhang, Yang Liu, Bin Wang, Meiqin Zheng, Lei Fu, Yanyan Hou, Ningbo Gong, Yang Lv, Chun Li, Christopher B. Cooper, Anna M. Upton, Dali Yin, Zhenkun Ma*, and Haihong Huang*. Identification of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis. Journal of Medicinal Chemistry, 2012, 55(19), 8409-8417 (IF=5.765)
17. 鲁海嘉,张东峰*,黄海洪，抗革兰氏阴性菌药物的研究进展，药学学报，2019, 54(9), 1554-1563
18. 丁威,赵文婷,张东峰*，结核分枝杆菌聚酮合成酶13抑制剂的研究进展，药学学报, 2020, 55(8), 1768-1773

1. 张东峰、黄海洪、赵文婷，色满酮类化合物及其制备方法和用途，201911014471.7
2. 黄海洪、张东峰、赵红义，含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途， PCT/CN2018/080777
3. 黄海洪、张东峰、高永鑫、林紫云、赵红义、高猛、马辰、李燕、盛莉，吡咯-2-甲酰胺类化合物及其制备方法和用途，PCT/CN2018/102618
4. 张东峰、黄海洪、李春、尹大力、林紫云、马辰、王迷娟、张猛、兰培、赵立敏，吡法齐明的制备方法，201711054900.4
5. 黄海洪、张东峰、林紫云、王晓良、彭英，硝酸2-（4-甲基噻唑-5-基）乙酯盐酸盐的制备方法，201611214110.3
6. 黄海洪、张东峰、赵红义，含四氢吡啶的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途，201611212328.5
7. 黄海洪、张东峰、吴永奇、鲁海嘉，苯并[1,3]噁嗪-噁唑烷酮类化合物及其制备方法和用途，202010080053.4
8. 赵红义、张东峰、李刚、黄海洪，特戈拉赞的制备方法，201911100878.1
9. Christopher B. Cooper, Haihong Huang, Dongfeng Zhang, Nader Fotouhi, Takushi Kaneko. Substituted phenyloxazolidinones and their antimicrobial activity, WO2017015106
10. Kai Liu, Christopher B. Cooper, Haihong Huang, Chun Li, Binna Liu, Yang Liu, Zhenkun Ma, Jingbin Wang, Dali Yin, Dongfeng Zhang, Gang Zhang, Hao Zhang. Riminophenazines with 2-(heteroaryl)amino substituents and their anti-microbial activity. US8716292
11. Liya Zhu, Wenjie Wang, Haihong Huang, Ziyun Lin, Liyuan Mou, Zhengui Nie, Yu He, Xueyu Ouyang, Shanying Peng, Dongfeng Zhang, Jun Wei. Arylamine ketones, their preparation methods, the pharmaceutical composition containing them and their use, US8524744
12. Chunrong Yu, Haihong Huang, Dongfeng Zhang, Peng Li. Protein kinase inhibitors, US9174996