一、 工作经历
2018.10--至今 bobapp官方下载 副研究员
2015.09-2018.09 bobapp官方下载 助理研究员
2013.08-2015.07 美国加州州立大学博士后研究员
二、教育背景
2009.09-2013.06 上海交通大学药学院博士
2006.09-2009.06 中国药科大学药学院硕士
2001.09-2005.06 海南师范大学化学系本科
三、在研项目
1. 基于一氧化氮供体抗COPD炎症的鸦胆苦醇衍生物的设计与合成，国家自然科学基金青年项目，国家级，负责人
2. 靶向Hedgehog通路新型菲骈吲哚里西啶抗神经胶质瘤化合物的设计、合成及机制研究，国家自然科学基金面上项目，国家级，负责人
3. 特殊资源药用植物中新颖结构天然产物的发现及其功能研究，国家自然科学基金重点项目，国家级，参与

1. Library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity. Rubing Wang#, Shuanggang Ma#*, Cooper S. Jamieson#, Rongmei Gao, Yunbao Liu, Yong Li, Xiaojing Wang, Yuhuan Li, Kendall N. Houk*, Jing Qu*, Shishan Yu*. Chem. Sci. 2021, 12: 7003-7011.
2. Structure-activity relationship and pharmacokinetic studies of 1,5-diheteroarylpenta- 1,4-dien-3-ones: A class of curcumin-based anticancer agents. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Changde Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. J. Med. Chem. 2015, 58(11): 4713-4726.
3. Illihenin A, an antiviral sesquiterpenoid with a cage-like tricyclo[6.2.2.01,5]dodecane skeleton from Illicium henryi. Jinyao Yong#, Wenrui Li#, Xiaojing Wang, Guozhu Su, Mi Li, Jianpei Zhang, Hongli Jia, Yuhuan Li, Rubing Wang*, Maoluo Gan*, Shuang-Gang Ma*. J. Org. Chem. 2021, 86: 2017-2022.
4. A role for isatin azomethine imines as a dipolarophile in cycloaddition reactions. Qingyun Fang, Haishan Jin, Rubing Wang*, Liming Zhao*. Org. Lett. 2020, 22: 7358-7362.
5. Burchellin and its stereoisomers: total synthesis, structural elucidation and antiviral activity. Rubing Wang#, Xiaodong Ren#, Jie He, Shanshan Zhu, Huiru Xie, Guozhu Su, Shuanggang Ma, Shishan Yu*. Org. Biomol. Chem. 2020,18: 9081-9087.
6. DABCO-mediated [3+3] cycloaddition of azomethine imines with in situ generated nitrile oxides from hydroximoyl chlorides. Qingyun Fang, Haishan Jin, Rubing Wang*, Liming Zhao*. Chem. Commun. 2019, 55: 10587-10591
7. New glycosides from the twigs and leaves of Rhododendron latoucheae. Yanan Wang, Fei Liu, Yong Li, Shuanggang Ma, Jing Qu, Yunbao Liu, Chongshan Niu, Zhonghai Tang, Yuhuan Li, Rubing Wang*, Shishan Yu*. J Asian Nat Prod Res. 2019, 21: 299-307.
8. Two azafluoranthene alkaloids and a phytoecdysone from the stems of Cyclea barbata. Xiaojing Wang#, Qi Zhang#, Yuru Peng, Li Li, Jing Qu, Yunbao Liu, Song Xu, Shuanggang Ma, Yong Li, Zou Zhongmei, Rubing Wang*, Shishan Yu*. J. Asian Nat. Prod. Res., 2019, 21: 217-226.
9. A novel and practical synthesis of CAT3: a phenanthroindolizidine alkaloid with potential in treating glioblastoma. Rubing Wang, Haining Lv, Shanshan Zhu, Xiaodong Ren, Song Xu, Shuanggang Ma, Yunbao Liu, Jing Qu*, Shishan Yu*. RSC Adv. 2018, 8: 29301-29308.
10. New C-2 diastereomers of flavanone glycosides conjugated with 3-hydroxy-3- methylglutaric acid from the pericarp of Citrus grandis (L.) Osbeck. Bioorg. Shuanggang Ma#, Rubing Wang#, Wenrui Li, Yunbao Liu, Jing Qu, Yong Li, Song Xu, Xiaojing Wang, Shishan Yu*. Bioorg. Chem. 2018, 80: 519-524.
11. Structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models. Rubing Wang, Xiaojie Zhang, Chengsheng Chen, Guanglin Chen,Cristian Sarabia, Qiang Zhang, Shilong Zheng, Guangdi Wang, QiaoHong Chen*. Eur. J. Med. Chem. 2017, 133: 208-226.
12. Synthesis and evaluation of 1,7- diheteroarylhepta-1,4,6-trien-2-ones as promising anticancer agents. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Eur. J. Med. Chem. 2016, 110: 164-180.
13. Design, synthesis and biological evaluation of shikonin and alkannin derivatives as potential antitumor agents via a prodrug approach. Rubing Wang#, Wen Zhou#*, Qingqing Meng, Xu Zhang, Jing Ding, Yan Xu, Hualong Song, Kai Yang, Jiahua Cui, Shaoshun Li*. ChemMedChem 2014, 9: 2798-2808.
14. Synthesis and evaluation of alkannin and shikonin oxime derivatives as potent antitumor agent. Rubing Wang#, Xu Zhang#, Hualong Song, Shanshan Zhou, Shaoshun Li*. Bioorg. Med. Chem. Lett. 2014, 24: 4304-4307.

1. (13aS)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的晶A型，中国发明专利，庾石山，陈晓光，王汝冰，吕海宁，徐嵩，季鸣，李燕，扈金平，马辰，张婷婷，马双刚，刘云宝 中国发明专利，申请号 201810117140.5
2. (13aS)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的晶B型, 庾石山，陈晓光，王汝冰，吕海宁，徐嵩，季鸣，李燕，扈金平，马辰，张婷婷，马双刚，刘云宝 中国发明专利，申请号 201810117139.2
3. 光学纯(S)-3-新戊酰氧基-6,7-二甲氧基-菲并吲哚里西啶的制备方法，庾石山，王汝冰，吕海宁，徐嵩，马双刚，刘云宝 中国发明专利，申请号 201810235803.3
4. 菲并吲哚里西定生物碱衍生物纳米自乳化组合物及其制备方法，刘玉玲，王洪亮，汪仁芸，夏学军，庾石山，陈晓光，李燕，王汝冰，季鸣，金晶，扈金萍 中国发明专利，申请号：201910673840.7
5. 菲并吲哚里西定生物碱衍生物固体脂质纳米粒组合物，刘玉玲，王洪亮，汪仁芸，夏学军，李琳，庾石山，陈晓光，李燕，扈金萍，高丽丽，王汝冰 中国发明专利，申请号：201911195675.5