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副研究员

田育林

职 称:副研究员

所属科室:合成药物化学研究室

导师类别:硕士生导师

联系方式:tianyulin@www.myhortonhome.com

所属重点实验室:天然药物活性物质与功能国家重点实验室;
活性物质发现与适药化研究北京市重点实验室

个人简介

田育林,博士,副研究员,硕士生导师。2010年本科毕业于沈阳药科大学基础药学理科基地班,2015年在北京协和医学院-bobapp官方下载 取得药物化学博士学位,2015-2018年在纽约州立大学水牛城分校从事博士后研究,2018年进入bobapp官方下载 工作,主要从事药物化学与化学生物学研究,近年来在J. Am. Chem. Soc., Org. Lett., Chem. Commun., ACS Chem. Biol.等杂志发表论文20多篇,2020年获得北京市科技新星计划资助。

研究方向

主要从事药物化学与化学生物学研究,具体包括:
1、发展基于生物正交反应的新型分子探针工具,应用于功能生物大分子的标记、修饰与功能调控。
2、基于化学蛋白质组学技术鉴定生物活性分子的靶标蛋白并阐明其作用机制。
3、基于结构的药物分子设计、合成与生物活性研究。

发表论文

1. Yulin Tian*, Hong Yang, Xiang Li, Yongcheng Wang, Yu Teng, Dali Yin, Design of Nitroso-Modified Naphthylene-Based Fluorophores as Photoactivatable Bioorthogonal Turn-On Probes, Org. Lett., 2021, 23(9): 3782-3787.
2. Yulin Tian, Ming Fang, Qing Lin*, Intracellular bioorthogonal labeling of glucagon receptor via tetrazine ligation. Bioorg. Med. Chem., 2021, 43: 116256.
3. Xiang Li, Yongcheng Wang, Hong Yang, Dali Yin, Yulin Tian*, Design of Hydrazone-Modified 1,8-Naphthalimides as Fluorogenic Click Probes Based on Nitrile Imine-Alkyne Cycloaddition, Eur. J. Org. Chem., 2020(2020): 4296–4300.
4. Yulin Tian*‡, Xiang Li‡, Dali Yin, Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling, Chem. Commun., 2019, 55(85): 12865-12868.
5. Yulin Tian, Qing Lin*, Fitness Factors for Bioorthogonal Chemical Probes, ACS Chem. Biol., 2019, 14(12): 2489−2496.
6. Yulin Tian, Huafei Zou, Peng An, Zhihong Zhou, Weijun Shen*, Qing Lin*, Design of stapled oxyntomodulin analogs containing functionalized biphenyl cross-linkers, Tetrahedron, 2019, 75(2): 286-295.
7. Yulin Tian, Qing Lin*, Recent Development of Photo-Cross-Linkers as Tools for Biomedical Research, Chimia, 2018, 72(11): 758-763.
8. Yulin Tian, Qing Lin,* Genetic encoding of 2-aryl-5-carboxytetrazole-based protein photo-cross-linkers, Chem. Commun., 2018, 54(35): 4449-4452.
9. Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu, Qing Lin*, Genetically encoded 2-aryl-5-carboxytetrazoles for site-selective protein photo-cross-linking, J. Am. Chem. Soc., 2017, 139(17): 6078–6081.
10. Yulin Tian, Xiaojian Wang*, Qiong Xiao, Chenbin Sun, Dali Yin*, Synthesis of dihydrobenzoheterocycles through Al(OTf)3-mediated cascade cyclization and ionic hydrogenation, J. Org. Chem., 2014, 79(20): 9678-9685.
11. Yulin Tian‡, Jing Jin‡, Xiaojian Wang*, Jinping Hu, Qiong Xiao, Wanqi Zhou, Xiaoguang Chen, Dali Yin*, Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design, Eur. J Med. Chem., 2014, 85: 1-15.
12. Yulin Tian, Jianguo Qi, Chenbin Sun, Dali Yin, Xiaojian Wang*, Qiong Xiao, One-pot synthesis of 4-methylisoquinolines via sequential Pd-catalyzed Heck reaction and intramolecular cyclization, Org. Biomol. Chem., 2013, 11(42): 7262-7266.
13. Yulin Tian, Jing Jin, Xiaojian Wang, Weijuan Han, Gang Li, Wanqi Zhou, Qiong Xiao, Jianguo Qi, Xiaoguang Chen, Dali Yin*, Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor, MedChemComm., 2013, 4(9): 1267-1274.

专著

专利


1. Oxyntomodulin analogs and methods of making and using same, Qing Lin, Avinash Muppidi, Weijun Shen, Huafei Zou, Peter Schultz, Yulin Tian, US Patent, 2018-04-03, No. US9931379B2.
2. 含五元芳杂环的氨基丙二醇类化合物、其制备方法及其医药用途,田育林、汪小涧、金晶、齐建国、周琬琪、陈晓光、尹大力,2019-04-09, 专利号:ZL201410053130.1.
3. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途,齐建国、汪小涧、金晶、田育林、周琬琪、陈晓光、尹大力,2018-10-30, 专利号:ZL201410053128.4.

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