教育背景 1999.09 – 2003.07 沈阳药科大学 工商管理学院，管理学学士
2003.09 – 2006.07 沈阳药科大学 药学院，药理学硕士
2006.09 – 2009.07 中国医学科学院&北京协和医学院 bobapp官方中国有限公司 ，药理学博士 工作经历 2009.09 – 2013.06 美国辛辛那提大学 医学院 药理及细胞生物物理系，博士后
2013.08 – 2014.08 中国医学科学院&北京协和医学院 bobapp官方中国有限公司 ，助理研究员
2014.09 – 2020.08 中国医学科学院&北京协和医学院 bobapp官方中国有限公司 ，副研究员
2020.09 – 今 中国医学科学院&北京协和医学院 bobapp官方中国有限公司 ，研究员

主要从事具有调节细胞自噬活性的小分子多肽以及天然产物活性分子在心血管疾病与肝纤维化发病过程中的作用和分子机制研究。近年来，作为课题负责人先后获得美国心脏学会、国家自然科学基金青年项目和面上项目、天然药物活性物质与功能国家重点实验室优秀青年基金、中国医学科学院协和青年基金、中国医学科学院“协和新星”基金、中国医学科学院药物所创新人才基金等多项基金资助。主要研究成果申请国家专利5项，并先后发表论文30余篇，作为第一或通讯作者在Autophagy、Circulation、JAHA、JMCC、Cardiovasc Res等国际权威杂志发表多篇研究论文。先后获得中国医学科学院 “协和新星”称号及第十八届SERVIER青年药理学工作者奖。

Klionsky DJ*, Cui B, Hua F, Li K, Zhang XW, Hu ZW, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autopahgy, DOI: 10.1080/15548627.2020.1797280, 2021
2. Xu AJ, Zhou JC, Li YM, Qiao LY, Jin CC, Chen W, Sun L, Wu SN, Li XJ, Zhou DH, Jia SY, Zhang B, Yao JY, Zhang XW*, You H*, Huang J*. 14-kDa Phosphohistidine Phosphatase is a Potential Therapeutic Target for Liver Fibrosis. Am J Physiol Gastrointest Liver Physiol, DOI: 10.1152/ajpgi.00334.2020, 2021 (* co-corresponding author)
3. Zhang XW, Zhou JC, Peng D, Hua F, Li K, Yu JJ, Lv XX, Cui B, Liu SS, Yu JM, Wang F, Jin CC, Yang ZN, Zhao CX, Hou XY, Huang B, Hu ZW*. Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation. Autophagy, 16(5):782-796, 2020
4. Liu P, Bao HY, Jin CC, Zhou JC, Hua F, Li K, Lv XX, Cui B, Hu ZW, Zhang XW*. Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin-Induced Heart Failure Through Resolution of Toll-Like Receptor 2-Mediated Myocardial Inflammation. J Am Heart Assoc, 8(20):e012338, 2019
5. Zhang XW, Sun L, Chen W, Wu SN, Li YM, Li XJ, Zhang B, Yao JY, Wang H, Xu AJ*. ARHGEF4-mediates the actin cytoskeleton reorganization of hepatic stellate cells in 3-dimensional collagen matrices. Cell Adh Migr, 13(1):169-181, 2019
6. Jin W, Cui B, Li PP, Hua F, Lv XX, Zhou JC, Hu ZW, Zhang XW*. 1,25- Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation. Acta Pharm Sin B, 8(2):178-187, 2018
7. Wu RN, Yu TY, Zhou JC, Li M, Gao HK, Zhao C, Dong RQ, Peng D, Hu ZW, Zhang XW*, Wu YQ*. Targeting HMGB1 ameliorates cardiac fibrosis through restoring TLR2-mediated autophagy suppression in myocardial fibroblasts. Int J Cardiol, 267:156-162, 2018 (* co-corresponding author)
8. Zhang XW, Mi S, Li Z, Zhou JC, Xie J, Hua F, Li K, Cui B, Lv XX, Yu JJ, Hu ZW*. Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes. Oncotarget, 8(6):9922-9934, 2017
9. Zhang XW, Zhou JC, Hu ZW*. Autophagy as a target for development of anti-diabetes drugs derived from natural compounds. J Asian Nat Prod Res, 19(4):314-319, 2017
10. Zhang XW, Wang XH, Zhu HY, Kranias EG, Tang YL, Peng TQ, Chang J, Fan GC*. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PLoS One, 7(3):e32765, 2012
11. Ma YG†, Zhang XW†, Bao HY, Mi S, Cai WF, Yan HM, Wang QQ, Wang ZY, Yan J, Fan GC, Lindsey ML, Hu ZW*. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS One, 7(7):e40763, 2012 († co-first author)
12. Wang XH†, Zhang XW†, Ren XP, Chen J, Liu HZ, Yang JQ, Medvedovic M, Hu ZW, Fan GC*. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/ reperfusion-induced cardiac injury. Circulation, 122(13):1308-18, 2010 († co-first author)
13. Zhang XW, Wang XH, Zhu HY, Zhu C, Wang YG, Pu WT, Jegga AG, Fan GC*. Synergistic effects of the GATA4- mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol, 49(5):841-50, 2010
14. Cai WF†, Zhang XW†, Yan HM, Ma YG, Wang XX, Yan J, Xin BM, Lv XX, Wang QQ, Wang ZY, Yang HZ, Hu ZW*. Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice. Cardiovasc Res, 88(1):140-9, 2010 († co-first author)
15. Jin CC, Zhang XW*. Research progress of natural medicines and bioactive compounds against heart failure. Acta Pharm Sin, 55(6): 1147-1156, 2020
16. Peng D, Hu ZW, Zhang XW*. Therapeutic perspectives of intestinal probiotics A. muciniphila in metabolic disorders. Acta Pharm Sin, 54(5): 768-777, 2019
17. Zhang XW, Cai WF, Hu ZW*. Advances in the study of immunopathological mechanism of dilated cardiomyopathy. Advances in Cardiovascular Diseases, 30(5):814-817, 2009
18. Yu JJ, Zhou DD, Yang XX, Cui B, Tan FW, Wang JJ, Li Ke, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F*, Hu, ZW*. TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target, Nat Commun. 2020, 111(1): 3660.
19. Yu JJ, Zhou DD, Cui B, Zhang C, Tan FW, Chang S, Li K, Lv XX, Zhang XW, Shang S, Xiang YJ, Chen F, Yu JM, Liu SS, Wang F, Hu ZW*, Hua F*. Disruption of the EGFR-SQSTM1 interaction by a stapled peptide suppresses lung cancer via activating autophagy and inhibiting EGFR signaling. Cancer Lett. 474:23-35, 2019
20. Yu JM, Sun W, Wang ZH, Liang X, Hua F, Li K, Lv XX, Zhang XW, Liu YY, Yu JJ, Liu SS, Shang S, Wang F, Yang ZN, Zhao CX, Hou XY, Li PP, Huang B, Cui B*, Hu ZW*. TRIB3 Supports Breast Cancer Stemness by Suppressing FOXO1 Degradation and Enhancing SOX2 Transcription. Nat Commun. 10(1):5720, 2019
21. Liu SS, Lv XX, Liu C, Qi J, Li YX, Wei XP, Li K, Hua F, Cui B, Zhang XW, Yu JJ, Yu JM, Wang F, Shang S, Zhao CX, Hou XY, Yao ZG, Li PP, Li X, Huang B, Hu ZW*. Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages. Immunity, 51(3):522-534.e7, 2019
22. Hua F, Shang S, Yang YW, Zhang HZ, Xu TL, Yu JJ, Zhou DD, Cui B, Li K, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Zhang C, Huang B, Hu ZW*. TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology, 156(3):708-721, 2019
23. Cui B, Eyers PA, Dobens LL, Tan NS, Mace PD, Link WA, Kiss-Toth E, Keeshan K, Nakamura T, Pear WS, Feseha Y, Johnston J, Carracedo A, Scheideler M, llyas Z, Bauer RC, Erusalimsky JD, Grzesik D, Salamanca-Viloria J , Lv XX, Jin YS, Li K, Velasco G, Shang S, Lizcano JM, Zhang XW, Zhou JC, Yu JJ, Hua F, Wang F, Liu SS, Yu JM, Hu ZW*. Highlights of the 2nd International Symposium on Tribbles and Diseases: Tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer. Acta Pharm Sin B. 9(2):443-454, 2019
24. Li K, Zhang TT, Wang F, Cui B, Zhao CX, Yu JJ, Lv XX, Zhang XW, Yang ZN, Huang B, Li X, Hua F, Hu ZW. Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression. Oncogene, 37(22):2967-2981, 2018
25. Li K, Wang F, Cao WB, Lv XX, Hua F, Cui B, Yu JJ, Zhang XW, Shang S, Liu SS, Yu JM, Han MZ, Huang B, Zhang TT, Li X, Jiang JD, Hu ZW*. TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence. Cancer Cell, 31(5):697-710, 2017
26. Xie J, Yun JP, Yang YN, Hua F, Zhang XW, Lin H, Lv XX, Li K, Zhang PC, Hu ZW*. A novel ECG analog 4-(S)-(2,4,6-trimethylthiobenzyl)-epigallocatechin gallate selectively induces apoptosis of B16-F10 melanoma via activation of autophagy and ROS. Sci Rep, 7:42194, 2017
27. Cui B, Cao XT, Zou WP, Wan YH, Wang N, Wang YH, Li PP, Hua F, Liu YY, Zhang XW, Li K, Lv XX, Huang B*, Hu ZW*. Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology. Acta Pharm Sin B. 7(4):532-540, 2017
28. Qi MY, Zhou JC, Zhang XW, Zhong XG, Zhang YP, Zhang XJ, Deng XL, Li HY, Wang QQ*. Effect of Xiaoqinglong decoction on mucus hypersecretion in the airways and cilia function in a murine model of asthma. J Tradit Chin Med Sci, 4:290-296, 2017
29. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW*. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun, 6:7951, 2015
30. Yan HM, Cui Bing, Zhang XW, Fu XM, Yan J, Wang XX, Lv XX, Chen Z, Hu ZW*. Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm. Acta Pharm Sin B, 45(3):176-187, 2015
31. Wang XH, Zhu HY, Zhang XW, Liu Y, Chen J, Medvedovic M, Li HL, Weiss MJ, Ren XP, Fan GC*. Loss of the miR-144/451 cluster impairs ischaemic preconditioning- mediated cardioprotection by targeting Rac-1. Cardiovasc Res, 94(2):379-90, 2012
32. Yan J, Wang ZY, Yang HZ, Liu HZ, Mi S, Lv XX, Fu XM, Yan HM, Zhang XW, Zhan QM, Hu ZW*. Timing is critical for an effective anti-metastatic immunotherapy: the decisive role of IFNγ/STAT1-mediated activation of autophagy. PLoS One, 6(9):e24705, 2011
33. Wang QQ, Yang HZ, Liu HZ, Mi S, Zhang XW, Yan HM, Ma YG, Wang XX, Hu ZW*. Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation. Acta Pharmacol Sin, 32(8):1045-54, 2011
34. Xin BM, Wang XX, Jin W, Yan HM, Cui B, Zhang XW, Hua F, Yang HZ, Hu ZW*. Activation of Toll-like receptor 9 attenuates unilateral ureteral obstruction-induced renal fibrosis. Acta Pharmacol Sin, 31(12):1583-92, 2010

1. 张晓伟，胡卓伟. 血管及血压调节的分子机制及药物应用. 王晓良等编著：应用分子药理学（第二版）. 中国协和医科大学出版社, 2015
2. 胡卓伟，张晓伟. 调节心脏组织重构和心肌再生治疗慢性心血管疾病. 王晓良等编著：应用分子药理学（第二版）. 中国协和医科大学出版社，2015
3. 吕晓希，张晓伟，胡卓伟. 自噬流检测的意义和方法. 秦正红等编著：自噬-生物学与疾病（第二版）. 科学出版社, 2015
4. 张晓伟，严君，胡卓伟. 皮肤纤维化实验方法和技术. 张均田等编著：现代药理实验方法（第二版）. 中国协和医科大学出版社，2012
5. 张晓伟，杨红振，贲长恩. 重要的促纤维化因子和抑纤维化因子. 牛建昭等编著：器官纤维化基础及中医药防治. 人民卫生出版社，2008

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