王金华，2004年毕业于北京大学。 2004-2006年在中国协和协和大学，bobapp官方下载 从事博士后研究。 2006年-2007在美国Case Western Reserve University， Department of Neuropathology任Research Associate。2007-2015年在美国John Wayne Cancer Institute先后任Medical scientist，Assistant professor, faculty。2015年3月回bobapp官方下载 工作。现任bobapp官方下载 国家新药筛选中心实聘课题组长；bobapp官方下载 、北京协和医学院引进人才、研究员、“协和学者” 特聘教授、博士生导师、中国医学科学院医学与健康科技创新工程协同创新团队首席科学家、赣江创新人才。 目前在APSB等多种学术期刊担任编委和审稿人。主持和承担国家自然科学基金，北京市自然科学基金和科技部项目。 一共发表科研论文90余篇，其中在Journal of Clinical Investigation (JCI)， Signal Transduction and Targeted Therapy， PNAS， Cancer research， Oncogene， Journal of Investigative Dermatology ，Cancer letter，Acta Pharmaceutica Sinica B等世界著名期刊发表SCI论文70余篇文章。

主要从事肿瘤的机制研究和抗肿瘤相关药物靶点的确认、药物筛选模型的建立及药物筛选、以及活性化合物的深入评价工作、利用人工智能、生物信息学和网络药理学研发新药。

1. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma. Tang Q, Li W, Zheng X, Ren L, Liu J, Li S, Wang J*, Du G*. Signal Transduct Target Ther. 2021 6(1):83-94.（IF: 18.187 ）
2. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. Jinhua Wang*, Ying Qu*, Partha S. Ray et al. Journal of Clinical Investigation. 2011;121(1):212-225. (The article was elected as highlighted article) (IF: 15.366)
3. 3-O-Acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma. Wan Li, Liwen Ren, Xiangjin Zheng, Jinyi Liu, Jinhua Wang*, Tengfei Ji*, Guanhua Du*. Acta Pharmaceutica Sinica B, 2020, 10(2): 301-12. (IF:11.413)
4. Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway. Xiangjin Zheng, Wan Li, Huanli Xu, Jinyi Liu, Liwen Ren, Yihui Yang, Sha Li, Wang Jinhua, Tengfei Ji, Guanhua Du, ,Acta Pharmaceutica Sinica B,2021(IF: 11.413)
5. The biology, function, and applications of exosomes in cancer. Jinyi Liu, Liwen Ren, Sha Li, Wan Li, Xiangjin Zheng, Yihui Yang, Weiqi Fu, Jie Yi, Jinhua Wang*, Guanhua Du. Acta Pharmaceutica Sinica B Jinyi Liu, Jinhua Wang*, et al. (In press). (IF: 11.413)
6. Members of FOX family could be drug targets of cancers. Pharmacol Ther. Jinhua Wang, Wan Li, Ying Zhao et al. 2018 Jan;181:183-196. (IF: 11)
7. The Sphingosine Kinase-1 / Sphingosine-1-Phosphate Axis in Cancer: Potential Target for Anticancer Therapy. Xiangjin Zheng, Wan Li, Liwen Ren, Jinyi Liu Jinhua Wang*. Pharmacology & Therapeutics. 2019 Mar; 195:85-99. (IF: 10.376).
8. EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers. Zheng XJ, Li W, Yi J, Liu JY, Ren LW, Zhu XM, Liu SW, Wang JH*, Du GH*. Acta Pharmacol Sin. 2020 Oct 14. (IF= 6.15)
9. Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest. Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang*, Cui Yang* and Guan-hua Du*. Acta Pharmacologica Sinica, 2020. (IF: 6.15)
10. Role of FOXC1 in regulation of basal-like/triple-negative breast cancer. P.S Ray, Jinhua Wang, Ying Qu, et al. Journal of Clinical Oncology. 2009; 27: 562S (No 15S, Part I of II). (IF: 17.255)
11. Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay. Jensen TW, Ray T, Wang Jinhua, Li X et al. J Natl Cancer Inst. 2015 Jun 3;107(8). (IF：13.584)
12. RASAL2 activates RAC1 to promote triple-negative breast cancer progression. Min Feng, Yi Bao, Zhimei Li, Jinhua Wang, Dave S.B. Hoon et al. J Clin Invest. 2014; 124(12):5291-5304. (IF: 13.261)
13. Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma. Iida Y, Ciechanover A, Jinhua Wang, Dave Hoon et al. Clin Cancer Res. 2017 Aug 15; 23(16):4831-4842. (IF: 9.619)
14. FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Jinhua Wang*, Partha S. Ray*, Ying Qu* et al. Cancer Research. 2010; 70(10):1-7. (The pictures in the article were chosen as the cover of magazine) (IF: 8.576)
15. JNK, essential for anticancer therapy-induced apoptosis promotes cancer breast progession. Jinhua Wang, I Kuiatse, AJ Casa, AV Lee, X Cui. Cancer Research. 2009; 69( suppl.):(2).January 15,2009 (IF：8.576)
16. Acquire resistance to braf-inhibitor by increasing EGFR expression. Jinhua Wang, Sharon Hunag, Ling Takeshima et al. Journal of Investigative Dermatology. 2015; 135:532-541. (IF: 7.216)
17. FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-kB signaling. Jinhua Wang, Ying Qu, Xiaojiang Cui et al. Oncogene, 2012 Nov 8;31(45):4798-802. (IF: 7.18)
18. RASSF8 Regulates Progression of Cutaneous Melanoma through Nuclear Factor-κb. Jinhua Wang, Wei hua, Sharon Huang et al. Oncotarget, 2015:6:30165-30177. (IF: 6.63)
19. P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway. Jinhua Wang, Hirose H, Du G et al. Cancer Lett. 2017 Oct 28;407:66-75. (IF: 6.491)
20. B7-H3 Associated with Tumor Progression and Epigenetic Regulatory Activity in Cutaneous Melanoma. Jinhua Wang, Kelly K. Chong, Yoshitaka Nakamura et al. Journal of Investigative Dermatology. 2013; 133(8):2050-8. (IF: 6.19)
21. Protein Tyrosine Phosphatase UBASH3B is Overexpressed in Triple-Negative Breast Cancer and Promotes Invasion and Metastasis. ShuetTheng Lee, min feng, Jinhua Wang et al. Proc Natl Acad Sci U S A. 2013, Jul 2; 110(27):11121-6. (IF: 9.598)
22. Antiangiogenesis Combined Photothermal Therapy in the Second Near Infrared Window at Laser Powers Below the Skin Tolerance Threshold. Jian‑Li Chen, Han Zhang, Xue‑Qin Huang, Hong‑Ye Wan, Jie Li, Xing‑Xing Fan, Kathy Qian Luo, Jinhua Wang, Xiao‑Ming Zhu1*, Jianfang Wang2*. Nano-Micro Lett. (2019) 11:93(IF: 9.043)
23. Epigenome-wide DNA Methylation Landscape of Melanoma Progression to Brain Metastasis Reveals Aberrations on Homeobox D Cluster Associated with Prognosis. Marzese DM, Scolyer RA, Jinhua Wang, Kawas NP et al. Human Molecular Genetics, 2013; 23(1): 226-38. (IF: 7.541)
24. MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. KatsuyaOhta, Hiromitsu Hoshino, Jinhua Wang et al. Oncotarget. 2015:6(5):3211-24. (IF: 6.63)
25. GD3s，a novel drug target of cancer. Jinyi Liu，Xiangjin Zheng，Xiaocong Pang, Cui Yang, Jinhua Wang*. Acta Pharmaceutica Sinica B. 2018 Sep;8(5):713-720（IF: 5.808 ）
26. 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. Wan Li, Jinyi Liu, Weiqi Fu, Xiangjin Zheng, Liwen Ren, Shiwei Liu, Jinhua Wang*, Tengfei Ji*, Guanhua Du*. Journal of Experimental & Clinical Cancer Research. 2018 Jul 3;37(1):132 (IF: 5.646 )
27. miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway. Wan Li, Jie Yi, Xiangjin Zheng, Shiwei Liu, Weiqi Fu, Liwen Ren, Li Li, Dave S. B. Hoon, Jinhua Wang*, Guanhua Du. Clinical Epigenetics. 2018 May 16;10:64.. (IF: 5.496 )
28. Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer. Jie Yu, Jinhua Wang* et al. Oncotarget. 2017 Mar 28; 8(13):20751-20765. (IF: 5.168)
29. Research progress on the Forkhead Box C1. Jinhua Wang et al. Oncotarget, 2017 Nov 20;9(15):12471-12478. (IF: 5.168)
30. Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer. Yi J, Gao R, Chen Y, Yang Z, Han P, Zhang H, Dou Y, Liu W, Wang W, Du G, Xu Y, Wang J*. Oncotarget. 2017 Mar 28;8(13):20751-20765. (IF: 5.168)
31. FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway. Wang Jinhua, Li Li, Liu Shiwei, Zhao Ying, Wang Lin, Du Guanhua. Oncotarget. 2016 Dec 20; 7(51):84375-84387. (IF: 5.168)
32. Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3-CHOP axis. Qin Tang, Liwen Ren, Jinyi Liu, Wan Li, Xiangjin Zheng, Jinhua Wang*, Guanhua Du*. Cell Prolif. 2019 Oct 23:e12706. (IF: 5.039)
33. Sustained JNK Activity Promotes Epithelial-Mesenchymal Transition, Invasion, and Survival of Breast Cancer Cells by Regulating ERK Activation. Jinhua Wang, Isere Kuiatse, Adrian V. Lee et al. Molecular Cancer Research, 2010; 8(2):266-277).The article was elected as highlighted article) (IF: 4.937)
34. Trefoil factor 1 (TFF1) is a potential prognostic biomarker with functional significance in breast cancers.Jie Yi, Liwen Ren, Dandan Li, Jie Wu, Wan Li, Guanhua Du, Jinhua Wang*. [J]. Biomedicine & Pharmacotherapy, 2020, 124(109827). (IF: 6.529)
35.Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells. Jinhua Wang*, Ying Qu*, Bingya Liu, Armando Giuliano et al. (Breast Cancer Research and Treatment, 2010; 121(2):311-21. (IF: 4.467)

1. 《丹参大全》. ISBN:978-7-117-09935-6/R.9936、编者、人民卫生出版社、2008出版
2. 《人类疾病动物模型》. ISBN: 978-7-81116-231-8. 编者 2007出版
3. 《天然小分子药物-源自于植物的小分子药物》副主编、人民卫生出版社、 2018出版
4. 《中药材“毒”之古今研究概评》 编委、 中国医药科技出版社、 2018出版
5. 《Nature small molecule drugs from plants》 编委 Springer Nature Singapore Pte Ltd. and People’s Medical Publishing House、2019 出版
6. 《中国医学科技发展报告》、编者、科学出版社2019出版
7. 《实验药理学（第2版）》，副主编，高等教育出版社，2020年出版。2021出版
8. 《漫话糖尿病》、编委、科学出版社、2017出版
9． 《糖尿病生活百科》编委 、科学出版社、2018出版

国际专利：
1. Patent 1: METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT OF PRIMARY AND METASTATIC BASAL-LIKE BREAST CANCER AND OTHER CANCER TYPES （Patent No. US 9074253 B2 授权日： 2015.7.7）.
2. Patent 2: DIAGNOSIS OF PRIMARY AND METASTATIC BASAL-LIKE BREAST CANCER AND OTHER CANCER TYPES （Patent No. EP 2486149 B1 授权日： 2015.6.17）.
国内专利：
3. 专利1：醉茄素A在制备预防或治疗胶质母细胞瘤药物中的应用。王金华等。申请号：201810266304.0
4. 专利2：乳香酸及其衍生物的制备与其抗神经胶质瘤的用途。王金华等。申请号：201810581480.3
5. 专利 3：阿伐麦布在制备预防或治疗胶质母细胞瘤药物中的应用。 王金华等。申请号：201811248470.4
6. 专利 4：载脂蛋白C 1在作为胃癌诊断及预后评价生物标记物中的应用。王金华等。申请号：201910163695.8
7. 专利 5：青藤碱类化合物在制备预防或治疗神经胶质瘤药物中的应用。王金华等。申请号：201910671599.4
8. 专利 6：三个唑类化合物在制备抗神经胶质瘤药物中的应用。王金华等。申请号：202010189295.7
9. 专利 7：黄芩素在制备预防和/或治疗新冠病毒感染疾病的药物中的应用。杜冠华，吕扬….王金华等。申请号：202010133944.1