李平平，博士，研究员，博士生导师。2015年获得协和学者特聘教授称号； 2016年入选国家自然基金委优秀青年；2017年入选求是杰出青年科学家。2018年入选北京高校“卓越青年”科学家，2020年获得第七届“树兰医学奖”。现任中国医学科学院代谢紊乱和肿瘤发生相关机制和靶点发现重点实验室主任，中国医学科学院北京协和医学院学术委员会委员，中国药学会青年委员会委员，北京市侨联青年委员会委员，北京生理科学会理事，中国医学科学院青年科学家联盟理事，卫生健康青年创新中心第一届青年导师团导师，《药学学报》和《Metabolism Open》 编委。累计发表SCI论文50余篇，引用5000余次。主要研究工作 （通讯作者或第一作者）发表在Cell（3篇）、Nature Medicine、Cell Metabolism、PNAS 和Diabetes 等期刊。

致力于肥胖、胰岛素抵抗及糖尿病发生的分子免疫学机制研究，目前课题组隶属于“天然药物活性物质与功能”国家重点实验室，主要研究领域包括内分泌学和内分泌药理学、免疫生物学和免疫药理、分子细胞生物学和药理学、信号传导通道调节机制等。

1. Negative Association between Caloric Intake and Estimated Glomerular Filtration Rate in a Chinese Population: Mediation Models Involving Mitochondrial Function. Chifa Ma , Shuli He , Pingping Li , Huabing Zhang , Wei Li , Yuxiu Li. Gerontology. 2020;66(5):439-446.
2. Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction. Yiwen Liu , Chifa Ma, Lu Lv , Pingping Li , Chunxiao Ma , Shuli He, Jingbo Zeng , Fan Ping , Huabing Zhang , Wei Li , Lingling Xu , Yuxiu Li. Oxid Med Cell Longev. 2020:5384909.
3. Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population. Yiwen Liu, Chifa Ma , Pingping Li , Chunxiao Ma , Shuli He , Fan Ping, Huabing Zhang , Wei Li , Lingling Xu , Yuxiu Li. Oxid Med Cell Longev. 2020:9256107.
4. Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity. Fangfang Sun, Yilie Liao, Xingfan Qu, Xia Xiao, Shaocong Hou, Zheqin Chen, Haipeng Huang, Pingping Li, and Suneng Fu. Cell Reports 2020; 30: 1835–1847.
5. Targeting Degradation of the Transcription Factor C/EBPbeta Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages. Liu, S. S., Lv, X. X., Liu, C., Qi, J., Li, Y. X., Wei, X. P., Li, K., Hua, F., Cui, B., Zhang, X. W., Yu, J. J., Yu, J. M., Wang, F., Shang, S., Zhao, C. X., Hou, X. Y., Yao, Z. G., Li, P. P., Li, X., Huang, B., and Hu, Z. W. Immunity 2019; 51, 522-534 e527.
6. Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells. Zhang, Q., Pan, Y., Zeng, B., Zheng, X., Wang, H., Shen, X., Li, H., Jiang, Q., Zhao, J., Meng, Z. X., Li, P., Chen, Z., Wei, H., and Liu, Z. Cell Res 2019, 29, 516-532.
7. TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription. Yu JM, Sun W, Wang ZH, Liang X, Hua F, Li K, Lv XX, Zhang XW, Liu YY, Yu JJ, Liu SS, Shang S, Wang F, Yang ZN, Zhao CX, Hou XY, Li PP, Huang B, Cui B, Hu ZW. Nat Commun. 2019 Dec 16;10(1):5720.
8. Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. Riopel, M., Seo, J.B., Bandyopadhyay, G.K., Li, P., Wollam, J., Chung, H., Jung, S.R., Murphy, A., Wilson, M., de Jong, R., et al. J Clin Invest 2018, 128, 1458-1470.
9. 1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation. Jin W, Cui B, Li PP, Hua F, Lv XX, Zhou JC, Hu ZW, Zhang XW, Acta Pharmaceutica Sinica B 2018; 8(2):178-187.
10. Inflammation and insulin resistance: New targets encourage new thinking: Galectin-3 and LTB4 are pro-inflammatory molecules that can be targeted to restore insulin sensitivity. Johnson, A. M. F., Hou, S., and Li, P. Bioessays 2017 39 (9) PMID: 28752547
11. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Ying, W., Riopel, M., Bandyopadhyay, G., Dong, Y., Birmingham, A., Seo, J. B., Ofrecio, J. M., Wollam, J., Hernandez-Carretero, A., Fu, W., Li, P., and Olefsky, J. M. Cell 2017.
12. Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology. Cui B*, Cao XT, Zou WP, Wan YH, Wang N, Wang YH, Li PP, Hua F, Liu YY, Zhang XW, Li K, Lv XX, Huang B#, Hu ZW#. Acta Pharmaceutica Sinica B 2017;7(4):532-540.
13. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. Ying, W., Wollam, J., Ofrecio, J. M., Bandyopadhyay, G., El Ouarrat, D., Lee, Y. S., Oh, D. Y., Li, P., Osborn, O., and Olefsky, J. M. J Clin Invest 2017 127, 1019-1030 PMID: 28192375
14. HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage. Qian, H., Chen, Y., Nian, Z., Su, L., Yu, H., Chen, F. J., Zhang, X., Xu, W., Zhou, L., Liu, J., Yu, J., Yu, L., Gao, Y., Zhang, H., Zhang, H., Zhao, S., Yu, L., Xiao, R. P., Bao, Y., Hou, S., Li, P., Li, J., Deng, H., Jia, W., and Li, P. J Clin Invest 2017 127, 1353-1369 PMID:28287402
15. Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Li PP*, Liu SN, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson, A.M.F., Sears D, Shen ZF, Cui B, Kong LJ, Hou SC, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM*. Cell 2016. 167(4):973-984.e12 (Lead Contact, * co-corresponding author) PMID: 27814523
16. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Baeza-Raja, B., Sachs, B. D., Li, P., Christian, F., Vagena, E., Davalos, D., Le Moan, N., Ryu, J. K., Sikorski, S. L., Chan, J. P., Scadeng, M., Taylor, S. S., Houslay, M. D., Baillie, G. S., Saltiel, A. R., Olefsky, J. M., and Akassoglou, K. Cell reports 2016 14, 255-268. PMID: 26748707
17. The role of dietary fat in obesity-induced insulin resistance. Lackey DE, Lazaro RG, Li P, Johnson A, Hernandez-Carretero A, Weber N, Vorobyova I, Tsukomoto H, and Osborn O. Am J Physiol Endocrinol Metab. 2016;311(6):E989-E97. PMID: 27802965
18. LTB4promotes insulin resistance in obese mice by acting on macrophages, hepatocytesand myocytes. Li P*, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A,Chung H, Mayoral R, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM*. Nat Med. 2015; 21(3): 239-47. (* co-corresponding author) PMID: 25706874.
19. FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance. Bernardo, B., Lu, M., Bandyopadhyay, G., Li, P., Zhou, Y., Huang, J., Levin, N., Tomas, E. M., Calle, R. A., Erion, D. M., Rolph, T. P., Brenner, M., and Talukdar, S. Scientific reports 2015 5, 11382. PMID: 26153793
20. Adipocyte SIRT1 knockout promotes PPARgamma activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh da, Y., Izquierdo, C. L., Chung, H., Li, P., Traves, P. G., Bandyopadhyay, G., Pessentheiner, A. R., Ofrecio, J. M., Cook, J. R., Qiang, L., Accili, D., and Olefsky, J. M. Molecular metabolism 2015, 4, 378-391. PMID: 25973386
21. Characterization of a novel glucokinase activator in rat and mouse models. Lu, M., Li, P., Bandyopadhyay, G., Lagakos, W., Dewolf, W. E., Jr., Alford, T., Chicarelli, M. J., Williams, L., Anderson, D. A., Baer, B. R., McVean, M., Conn, M., Veniant, M. M., and Coward, P. PloS one 2014, 9, e88431. PMID: 24533087
22. NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids. Li, P. *, Spann, N.*, Kaikkonen, M., Lu, M., Oh, D., Fox, J., Bandyopadhyay, G., Talukdar, S., Xu, J., Lagakos, W., Patsouris, D., Armando, A., Quehenberger, O., Dennis, E., Watkins, S., Auwerx, J., Glass, C., Olefsky, J. Cell 2013; 155, 200-214. (* co-first author) PMID: 24074869
23. Neuronal sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. Lu, M., Sarruf, D.A., Li, P., Osborn, O., Sanchez-Alavez, M., Talukdar, S., Chen, A., Bandyopadhyay, G., Xu, J., Morinaga, H., et al. The Journal of biological chemistry 2013, 288, 10722-10735. PMID: 23457303
24. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Reilly, S. M., Chiang, S. H., Decker, S. J., Chang, L., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J., White, N. M., Hochberg, I., Downes, M., Yu, R. T., Liddle, C., Evans, R. M., Oh, D., Li, P., Olefsky, J. M., and Saltiel, A. R. Nature medicine 2013,19, 313-321. PMID: 23396211
25. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Baeza-Raja B, Li PP*, D. Sachs B, Davalos D, Eirini Vagena, Schachtrup C, Loucks FA, Sikorski S, Helmrick M, Le Moan N, Bridges D, Tsigelny I, Baron LJ, Wynshaw-Boris. Anthony , Miriam Scadeng, Saltiel AR, Olefsky JM, Akassoglou K .Proc Natl Acad Sci U S A 2012; 109(15):5838-43 (* co-first author) PMID: 22460790
26. Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Li PP*, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. Cell 2011;147:815-826. PMID: 22078880
27. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. Li PP*, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM. J Biol Chem 2010;285:15333-15345. PMID: 20308074
28. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Lu M, Li PP*, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM. Mol Endocrinol 2010;24:1413-1422. (* co-first author). PMID: 20444886