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研究员

李莉

职 称:研究员

所属科室:合成药物化学研究室

导师类别:博士生导师

联系方式:

所属重点实验室:活性物质发现与适药化研究北京市重点实验室

个人简介

1997年7月毕业于北京师范大学化学系,获学士学位。2002年6月毕业于中国医学科学院放射医学bobapp官方下载 ,获影像医学与核医学专业博士学位,研究方向是放射性药物的合成、标记和活性研究。2002年7月至2004年6月,在bobapp官方下载 进行博士后研究工作,研究内容包括“似药”小分子杂环化学库的构建和SARS“交叉重迭”多肽化学库的合成。2004年7月至今在bobapp官方下载 工作,研究方向是与新药发现有关的化学生物学研究和立体化学研究。先后参加了国家自然科学基金、国家科技攻关项目、科技部863项目、科技部SARS专项等课题的研究。近期主要开展手性光谱学研究以及新药设计与合成工作。

研究方向

1. 手性光谱学基础与应用研究,包括:手性药物和天然产物的立体结构分析、手性拆分、手性传感等。
2. 新药设计与合成,主要集中在抗肿瘤和抗帕金森病领域。

发表论文


1. Regioselectivity of aminomethylation in 3-acetyl-7-hydroxycoumarins: Mannich bases and Betti bases. Fan Gao, Deng Tao, Cheng Ju, Bei-Bei Yang, Xiu-Qi Bao, Dan Zhang, Tian-Tai Zhang, Li Li*. New Journal of Chemistry, 2021, 45, 9864 - 9871.
2. Specific Optical Rotation and Absolute Configuration of Flexible Molecules Containing a 2-Methylbutyl Residue. Jia-Min Lu, Bei-Bei Yang, Li Li*. European Journal of Organic Chemistry, 2020, 30, 4768-4774.
3. A Rapid and Sensitive Method for Chiroptical Sensing of -Amino Acids via Click-like Labeling with o-Phthaladehyde and p-Toluenethiol. Bo Li, Jie Zhang, Li Li*, Gong Chen*. Chemical Science, 2021, 12, 2504-2508.
4. Ultrasound-promoted specific chiroptical sensing of cysteine in aqueous solution and cells. Fei Xiong, Jun-Yao Zhang, Ting-Ting Du, Bei-Bei Yang, Xiao-Guang Chen, Li Li*. Microchemical Journal, 2020, 153, 104471.
5. Isolation and characterization of cytotoxic withanolides from the calyx of Physalis alkekengi L. var franchetii. Yi Sun, Tao Guo, Fang-Bo Zhang, Ya-Nan Wang, Zhi-Guo Liu, Shan-Shan Guo, Li Li*. Bioorganic Chemistry, 2020, 96, 103614.
6. Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease. Deng Tao, Yue Wang, Xiu-Qi Bao, Bei-Bei Yang, Fan Gao, Lin Wang, Dan Zhang*, Li Li*. European Journal of Medicinal Chemistry, 2019, 173, 203-212.
7. Cytotoxic Withanolides from the Whole Herb of Physalis angulata L. Qinghong Meng, Jiajia Fan, Zhiguo Liu, Xiwen Li, Fangbo Zhang, Yanlin Zhang, Yi Sun*, Li Li* , Xia Liu, Erbing Hua*. Molecules, 2019, 24(4), 1608.
8. Chiral resolution, absolute configuration determination, and stereo-activity relationship study of the IDO1 inhibitor NLG919. Wen-Qiang Liu, Fang-Fang Lai, Jie Zhang, Li Sheng, Yan Li, Li Li*, Xiao-Guang Chen*. Tetrahedron, 2018, 74 (24), 3045-3051.
9. Alashinol H, an epoxylignan with an unusual six-membered cyclic hemiacetal from Syringa pinnatifolia. Guozhu Su, Shungang Jiao, Ruifei Zhang, Li Li*, Suyile Chen, Pengfei Tu, Xingyun Chai*. Tetrahedron Letters, 2018, 59, 1356-1359.
10. Lignans and isoflavonoids from the stems of Pisonia umbellifera. Zhiguo Liu, Xilong Zheng, Yanan Wang, Mengyue Tang, Shilin Chen, Fangbo Zhang, Li Li,* Cun Zhang*, Yi Sun*. RSC Advances, 2018, 8, 16383-16391.
11. Enantioseparation, stereochemical assignment and chiral recognition mechanism of sulfoxide-containing drugs. Fei Xiong, Bei-Bei Yang, Jie Zhang, Li Li*. Molecules, 2018, 23(10), 2680.
12. Ring-locking strategy facilitating determination of absolute optical purity of 2-amino-1-butanol by reverse-phase high-performance liquid chromatography. Bo Li, Jie Zhang, Bei-Bei Yang, Li Li*, Xiao-Xiao Yang*. RSC Advances, 2017, 7, 45714-45720.
13. A high-performance liquid chromatography-electronic circular dichroism online method for assessing the absolute enantiomeric excess and conversion ratio of asymmetric reactions. Xiang Zhang, Ming-Chao Wang, Li Li*, Da-Li Yin*. Scientific Reports, 2017, 7: 43278.
14. Improved synthesis of unnatural amino acids for peptide stapling. Bo Li, Jie Zhang, Yongjuan Xu, Xiaoxiao Yang*, Li Li*. Tetrahedron Letters, 2017, 58(24): 2374–2377.
15. Azacyclo-indoles and Phenolics from the Flowers of Juglans regia. Qian Li, An-Jun Deng, Li Li*, Lian-Qiu Wu, Ming Ji, Hai-Jing Zhang, Zhi-Hong Li, Lin Ma, Zhi-Hui Zhang, Xiao-Guang Chen, and Hai-Lin Qin*. Journal of Natural Products, 2017, 80, 2189-2198.
16. Six scalemic mixtures of 6-monosubstituted dihydrobenzophenanthridine alkaloids from Chelidonium majus and optically active structures of enantiomers. An-Jun Deng, Hai-Jing Zhang, Qian Li, Zhi-Hong Li, Zhi-Hui Zhang, Lian-Qiu Wu, Li Li*, Hai-Lin Qin*. Phytochemistry, 2017, 14, 159-170.
17. Decalin-Containing Tetramic acids and 4-hydroxy-2-pyridones with Antimicrobial and Cytotoxic Activity from the Fungus Coniochaeta cephalothecoides Collected in Tibetan Plateau (Medog). Junjie Han*, Congcong Liu*, Li Li*, Hui Zhou, Li Liu, Li Bao, Qian Chen, Fuhang Song, Lixin Zhang, Erwei Li, Ling Liu, Yunfei Pei, Cheng Jin, Yanfen Xue, Wenbing Yin, Yanhe Ma, Hongwei Liu. The Journal of Organic Chemistry, 2017, 82, 11474-11486.

专著

1. 《药理学研究中的新技术与新方法》,编者,中国协和医科大学出版社,2014年。

专利


18. 苯并咪唑并2-氨基-1,3,4-噻二唑化合物及其制法和药物用途。李莉,陈晓光,刘文强,金晶,季鸣,杜婷婷,张倩倩,杨蓓蓓,伏蓉。申请号:202011130885.9。申请日:2020/10/21。
19. 一种识别氨基酸及肽类化合物绝对构型和光学纯度的方法。李莉,张洁,李博,杨蓓蓓,熊斐,陶登,刘文强,卢家民。申请号:201810235875.8。申请日:2018/03/21。
20. 1-环己基-2-(5H-咪唑[5,1-a]异吲哚)乙基-1-酮的拆分。李莉,刘文强,张洁,杨蓓蓓。申请号:201611213882.5。申请日:2016/12/26。
21. 香豆素曼尼希碱及其在防治神经退行性疾病中的用途。李莉,王琳,张丹,鲍秀琦,高琦,臧彩霞,郑远鹏。申请号:201611177885.8。申请日:2016/12/20。

科技奖励

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