张青扬，博士，副研究员，硕士生导师。2013年毕业于中国医学科学院&北京协和医学院bobapp官方中国有限公司 ，获药物化学博士学位。2015年进入bobapp官方下载 工作，2018年获聘副研究员，专注于分子探针构建及功能化、创新药物发现新策略等方面的研究工作。作为项目负责人，先后主持了国家自然科学基金青年基金项目和面上项目，并参与了国家十三五重大新药创制项目以及中国医学科学院十三五、十四五医学与健康科技创新工程项目。近年来，以第一作者或通讯作者身份发表SCI论文十余篇，申请专利6项，授权专利3项，并参与编译了《化学生物学》教材。
以化学生物学为基础，从事分子探针的设计、合成及功能化研究，旨在针对细菌感染、肿瘤及细胞衰老相关疾病进行新型治疗、检测试剂的研发，并深入探究其分子机制。具体研究内容包括：1. 响应型荧光分子探针的设计、合成及功能化研究；2. 基于分子探针的细菌感染相关物质检测及作用机制研究；3. 热激活延迟荧光分子驱动的荧光时间分辨成像及生物学应用；4. 基于新策略的创新药物研发。
1. Xiaowan Han#, Xiangchuan Meng#, Xiang Wang#, Shan Leng, Qian Liu, Leilei Zhang, Pingping Li, Qingyang Zhang*, and Hai-Yu Hu*. Analyte-Triggered Excited-State Intramolecular Proton Transfer-Delayed Fluorescence: A General Approach for Time-Resolved Turn-on Fluorescence Imaging. Analytical Chemistry 2023, 95, 7715−7722.
2. Qian Liu#, Miao Yang#, Xiangchuan Meng, Xiaowan Han, Marc Nazare, Youjun Xu,* Hai-Yu Hu,* and Qingyang Zhang*. Donor Manipulation for Constructing a pH Sensing Thermally Activated Delayed Fluorescent Probe to Detect Alkaliphiles. Talanta 2022, 246, 123493.
3. Shengnan Xu#, Qingyang Zhang#, Xiaowan Han, Yali Wang, Xiang Wang, Marc Nazare, Jian-Dong Jiang,* and Hai-Yu Hu*. Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues. ACS Sensors 2020, 5, 1650-1656.
4. Lintao Wu, Chun Han, Zhijun Wang, Xi Wu, Feng Su, Mengyao Li, Qingyang Zhang* and Xiaobi Jing*. Porphyrin-Based Organoplatinum(II) Metallacycles With Enhanced Photooxidization Reactivity. Frontiers in Chemistry 2020, 8, 262.
5. Na Zhang#, Yali Wang#, Shan Leng#, Shengnan Xu, Leilei Zhang, Qinghua Wang, Qingyang Zhang* and Hai-Yu Hu*. An Efficient Fluorescence Sensor for Nitroreductase Selective Imaging Based on Intramolecular Photoinduced Electron Transfer. Talanta 2019, 205, 120133.
6. Qingyang Zhang#, Shengnan Xu#, Meng Li#, Yali Wang, Na Zhang, Yan Guan, Mingxing Chen, Chuan-Feng Chen* and Hai-Yu Hu*. Rationally designed organelle-specific thermally activated delayed fluorescence small molecular organic probes for time-resolved biological applications. Chemical Communications 2019, 55, 5639-5642.
7. Qingyang Zhang#, Shengnan Xu#, Fangfang Lai#, Yali Wang, Na Zhang, Marc Nazare, and Hai-Yu Hu*. Rapid Synthesis of γ-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen. Organic Letters 2019, 21 (7), 2121-2125.
8. Yubin Ji#, Yali Wang#, Na Zhang#, Shengnan Xu, Leilei Zhang, Qinghua Wang, Qingyang Zhang* and Hai-Yu Hu*. Cell-permeable Fluorogenic Probes for Identification and Imaging Nitroreductases in Live Bacterial Cells. The Journal of Organic Chemistry 2019, 84 (3), 1299-1309.
9. Yubin Ji, Na Zhang, Yali Wang, Qingyang Zhang* and Hai-Yu Hu*. Research Progress of Thermally Activated Delayed Fluorescence Probes for Biological Applications. Chinese Medicinal Biotechnology 2018, 13 (6), 532-538. (Review)
10. Qingyang Zhang#, Qinghua Wang#, Yin Sun; Liming Zuo, Verena Fetz, Hai-Yu Hu*. Superior Fluorogen-Activating Protein Probes Based on 3-Indole-Malachite Green. Organic Letters 2017, 19, 4496-4499.
11. Qingyang Zhang#, Qinghua Wang#, Shengnan Xu, Limin Zuo, Xuefu You, Haiyu Hu*. Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications. Chemical Communications 2017, 53 (8), 1366-1369.
1. 超敏感荧光探针检验细菌中硝基还原酶及在细菌感染应用，bobapp官方下载
，2019-10-231.
2．一种热激活延迟荧光探针分子、其制备及其在细胞成像中的应用，bobapp官方下载
，2019-3-041.
3．热激活延迟荧光( TADF )纳米探针及其制备方法和在生物成像中的应用，哈尔滨医科大学，2018-11-08
