崔华清，bobapp官方下载 研究员，2010年获得德国海德堡大学药物化学博士。研究经历还包括美国明尼苏达大学药物设计中心博士后；英国邓迪大学生物化学与药物研发中心博士交流生、西班牙国家研究机构生物医学与寄生虫病bobapp官方下载 博士交流生。2013年6月加入bobapp官方下载 合成药物化学研究室工作。

1，经典药物化学：基于先导化合物，设计与合成小分子干扰剂，进行药物靶点活性的评价。活性好的化合物继续进行成药性评价，获取临床候选化合物。
2，靶点活性筛选：选取药物蛋白靶标，获取重组蛋白，设计合成底物探针，建立高效、准确的分子水平筛选方法，尤其擅长建立荧光检测方法。
3，体外诊断试剂研发：通过化学与生物学科的交叉方法，专注于研发创新类体外诊断试剂。如，荧光分子探针、核苷类分子探针及其他生化试剂在IVD中的应用。

1, Yikun Chen, Yongxin Gao, Yujun He, Gang Zhang, Hui Wen, Yuchen Wang*, Qinpei Wu*, Huaqing Cui*. Determining essential requirements for fluorophore selection in various fluorescent applications taking advantage of diverse structure fluorescence information of chromone derivatives. J. Med. Chem., 2021; 64(2):1001-1017.
2, Yanzhao Xu, Na Qi, Hui Wen, Gang Zhang, Yuchen Wang*, Huaqing Cui*. Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors. Med. Chem. Res., 2021, 30: 387-398.
3, Yuchen Wang‡, Jianyi Han‡, Yanzhao Xu, Yongxin Gao, Hui Wen*, Huaqing Cui*. Taking advantage of the aromatisation of 7-diethylamino-4-methyl-3, 4-dihydrocoumarin to fluorescently sense superoxide anion. ChemComm., 2020, 56 (68): 9827-9829.
4, Yujun He, Jin Wen, Qinghua Cui, Fangfang Lai*, Dali Yin, Huaqing Cui*. Precisely evaluation in vivo target efficacy of anti-tumour agents via an immunofluorescence and EdU labelling strategy. Front Pharmacol., 2018, 9:812.
5, Ning Yan, Yujun He, Hui Wen, Fangfang Lai, Dali Yin, Huaqing Cui*. A Suzuki-Miyaura Protocol for Labelling Proliferating Cells Containing Incorporated BrdU. Analyst, 2018, 143(5), 1224-33.
6, Chunxian He, Laura Preiss, Bing Wang, Lei Fu, Hui Wen, Xiang Zhang, Huaqing Cui*, Thomas Meier*, and Dali Yin*. Fragment based structural simplification of bedaquiline: the discovery of 3-(4-(N, N-dimethylaminomethyl)phenyl)-quinoline derived anti-tubercular lead compounds. ChemMedChem., 2017,12 (2):106-119.
7, Hui Wen, Qinghua Cui, Hui Meng, Fangfang Lai, Xiang Zhang, Xiaoguang Chen, Huaqing Cui*, Dali Yin*. A high-resolution method to assess cell multinucleation with cytoplasm-localized fluorescent probes. Analyst., 2016, 141 (13), 4010-3.
8, Jianzhuang Miao‡, Huaqing Cui‡,*, Jing Jin, Fangfang Lai, Hui Wen, Xiang Zhang, Gian Filippo Ruda, Xiaoguang Chen, Dali Yin*. Development of 3-alkyl-6-methoxy-7-hydroxychromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging. ChemComm. 2015, 51 (5): 881-5.
9, Huaqing Cui, Zeeshan Kamal, Teng Ai, Yanli Xu, Swati S More, Daniel Wilson, Liqiang Chen. Discovery of potent and selective Sirtuin 2 (SIRT2) inhibitors using a fragment-based approach. J. Med. Chem. 2014, 57:8340-8357;
10, Huaqing Cui, Juana Carrero-Lérida, Ana. Silva, Jean L Whittingham, James A Brannigan, Luis Ruiz-Pérez, Kevin Read, Keith S Wilson, Dolores. González-Pacanowska, Ian H Gilbert. Synthesis and evaluation of α-thymidine analogues as novel antimalarials. J. Med. Chem. 2012, 55 (24): 10948-10957.

1. 色原酮类衍生物和作为荧光染料的用途；崔华清、尹大力、苗建壮、张翔； 2019授权；ZL201410394755.4
2. 一类邻位羰基氨基取代衍生物的制备方法和用途；陈晓光、崔华清、文辉等；2019申请；201910263113.3
3. 一类邻位羰基氨基取代衍生物的制备方法和用途；陈晓光、崔华清、文辉等；2020申请；PCT/CN2020/080517
4. 一类含亚砜的苯并恶唑衍生物及其制备方法和用途；崔华清、文辉、王雨辰、贾淑密、王婷、齐娜；2021申请；202110328645.8