科研队伍

谢平,博士,研究员,博士研究生导师。主要致力于从复杂活性天然产物出发,经过结构修饰及简化,寻找具有全新结构的新药。作为合成部分的负责人参加了两个创新药物即具有抗肾衰的新药硝克柳胺(临床II期)及抗帕金森氏症的新药芬乐胺(已完成I期临床研究,正进入II临床)的研发工作。作为负责人承担了十二五创制科技重大专项候选药研究项目,参加了十一五、十二五、十三五综合大平台,全球结核病药物研发联盟新型噁唑烷酮类抗结核新药发现项目,医科院创新工程以及药物所国家重点实验室等项目。近年来作为通讯作者在Org. Lett.; Acta Pharm. Sinica B; Bioorganic Chemistry; Org. & Bio. Chem., Tetrahedron等杂志发表SCI论文10多篇;申请及授权专利多项。

1. 活性天然产物的全合成及结构修饰
2. 手性药物及中间体的催化合成及方法学研究
3. 药物分子设计及合成
4. 创新药物的研发

1. Total Synthesis of the Proposed Structure of Characellide B, Yong Wang†, Zhenwei Wang†, Zhe Wang†, Xiaoyu Liu, Yingjun Jiang, Xiaozhen Jiao* and Ping Xie*, Org. Lett., 2021, 23, 3680-3684. (IF=6.091 )
2. Discovery of CAPE derivatives as dual EGFR and CSK inhibitors with anticancer activity in a murine model of hepatocellular carcinoma, Xiaoyu Liu (#), Qianqian Du (#), Caiping Tian, Mei Tang , Yingjun Jiang , Yong Wang , Yang Cao , Zhe Wang , Zhenwei Wang , Jing Yang, Yan Li *, Xiaozhen Jiao, Ping Xie*. Bioorganic Chemistry, 2021, 107, 104536. (IF=5.275 )
3. Total Synthesis of Bysspectin A, Feilong Yang, Xiaoyu Liu, Xiang Shi, Yong Wang, Guoru Hu, Sheng Lin, Xiaozhen Jiao* and Ping Xie* , Tetrahedron, 2019, 75, 3101-3107.(IF=2.33 )
4. Asymmetric total synthesis of (t)-isocryptotanshinone and formal synthesis of (-)-cryptotansh- inone, Xiang Shi, Xiaoyu Liu, Feilong Yang, YongWang, ZhenweiWang, Xiaozhen Jiao*, Ping Xie*, Tetrahedron, 2019, 75, 3962-3967. (IF=2.33 )
5. Enantioselective Total Synthesis of Colomitides and their Absolute Configuration Determina- tion and Structural Revision, Hongguang Yang, Xiaoyu Liu, Xiaoyu Li, Xiang Shi, Feilong Yang, Xiaozhen Jiao*, Ping Xie*, Org. & Bio. Chem., 2017, 15, 3728- 3735. (IF=3.423 )
6. Discovery of novel N-substituted-prolinamido indazoles as potent Rho kinase inhibitors and vasorelaxation agents, Yangyang Yao†,Renze Li†, Xiaoyu Liu, Feilong Yang, Ying Yang, Hongguang Yang, Xiaoyu Li, Xiang Shi, Tianyi Yuan, Lianhua Fang, Guanhua Du, Xiaozhen Jiao*, Ping Xie*, Molecules, 2017, 22, 1766-1781. (IF=3.098 )
7. Total Synthesis and Stereochemical Revision of Xiamenmycin A, Xiao-zhen Jiao, Yang-yang Yao, Bei-bei Yang, Xiao-yu Liu, Xiao-yu Li, Hong-guang Yang, Li Li, Jun Xu, Min-juan Xu,*Ping Xie*, Organic & Biomolecular Chemistry, 2016, 14,1805-1813. (IF=3.564 )
8. An approach to (±)-Lingzhiol, Xiaoyu Li, Xiaoyu Liu, Xiaozhen Jiao, Hongguang Yang, Yangyang Yao Ping Xie*, Org. Lett., 2016, 18, 1944-1946. (IF=6.732 )
9. A practical synthesis of chiral tricyclic cyclopenta[b]benzofuran, a key intermediate of Beraprost, Xiao-yu Liu, Cheng-sen Tian, Xiao-zhen Jiao, Xiao-yu Li, Hong-guang Yang, Yang-yang Yao, and Ping Xie*, Organic & Biomolecular Chemistry, 2016, 14, 7715 –7721. (IF=3.559 )
10. Total Synthesis of Xiamenmycin C and All of Its Stereoisomers: Stereochemical Revision, Yang-yang Yao, Xiao-yu Liu, Xiao-yu Li, Hong-guang Yang, Li Li, Xiao-zhen Jiao*, Ping Xie *, Journal of Asian Natural Products Research, 2016, 18(10), 976-987. (IF=1.071 )

1. 伊力格鲁司他的制备方法。谢平、刘晓宇、焦晓臻、李晓宇、杨红光、施翔、杨飞龙。ZL201810305457.1授权日:2021-1-12. 中国
2. 吲唑类化合物,其制备方法及其药物用途(中国)。方莲花、谢平、杜冠华、王丽萍、袁天翊、焦晓臻、王夙博、李人则、郭晶、宫丽丽 ZL201210172191.0授权日:2017-6-23. 中国
3. 三白脂素结构简化物其制法和其药物组合物与用途。谢平、陈晓光、 焦晓臻、刘晓宇、李燕、张翼、郎立伟、王丽萍、李人则. ZL201110141751.1授权日:2016-3-9. 中国
4. 吲唑类化合物在制备预防和、或治疗肺动脉高血压中的药物用途。方莲花,谢平,杜冠华,袁天翊,焦晓臻,陈俞林;申请号:201510268489.5
5. 3-(1H-吲唑)-四氢嘧啶-2-酮类化合物其制备方法及其用途,方莲花,焦晓臻,杜冠华,谢平,袁天翊,姚阳阳,陈俞材,张惠芳.申请号:201610346543.8申请日:2016.5.24, 中国
6. 木脂素类天然产物4-O-甲基三白草醇的结构简化物,其制法和其药物组合物与用途。李燕、谢平、刘晓宇、焦晓臻、杜倩倩、李晓宇、杨飞龙 申请号:201711282043.3 申请日:2017.12.7,中国
7. 咖啡酸苯乙酯类衍生物,其制法和其药物组合物与用途。谢平、李燕、焦晓臻、刘晓宇、唐梅、王勇、杜倩倩。申请号:201910264532.9 申请日:2019.4.3,中国
8. 2,3-二氢萘并[2,3-b]呋喃-4,9-二酮类化合物及其制备方法和用途。谢平、陈晓光、焦晓臻、施翔、刘晓宇、薛妮娜、季鸣、杜婷婷、王振伟。申请号:201910311646.4 申请日:2019.4.18,中国
9. 木脂素类衍生物及其制法和其药物组合物与用途。谢平、李燕、焦晓臻、刘晓宇、姜英俊、郑凯露、邓海东、王哲、王振伟、曹泱、吴媛媛 申请号:20210277262.2 申请日:2021.3.16,中国

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