1977年于中山医学院医疗系毕业后，在医科院药物所药理专业班学习，曾在美国Texas A&M大学医学院进修。40余年来在药物所从事抗糖尿病相关药理学及新药研发。先后负责"九五"国家攀登计划、国家及北京市自然科学基金、国家新药基金、国家重大新药创制等项目，以及数十项横向课题。作为负责人或主要参与人，获新药证书7个和上市注册批件2个，2020.3月获批的创新药物—桑枝总生物碱片，为国内首个植物有效组分降血糖原创天然药物。申请专利50余项，授权20余项；获卫生部科技进步奖1项、中华医学会科技进步奖3项、北京市科学技术奖3项、教育部科技进步奖1项、国家科技进步奖1项；发表论文200余篇，参编论著21部。培养研究生等近50名。是享受国务院特贴专家。
专注于防治糖尿病及其慢性并发症（肾脏、眼和神经）、肥胖、高脂血症等多种代谢性疾病的药理学及新药研发工作。包括体内外模型和技术方法建立、药理作用机制、新靶点、药效学评价、新药发现等。涉及植物药与中药、中药复方、化药以及生物制品；涵盖α-葡萄糖苷酶抑制剂、重组/口服胰岛素、GLP-1类似物、胰岛素增敏剂、DPP-4抑制剂、GK激活剂、SGLT2抑制剂、FBPase抑制剂、PCSK9抑制剂、HMG-CoA抑制剂、G蛋白偶联受体激动剂、醛糖还原酶抑制剂以及多靶点作用等。
1. Efficacy and Safety of Mulberry Twig Alkaloids Tablet for the Treatment of Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy, and Parallel Controlled Clinical Trial. Ling Qu, Xiaochun Liang, Guoqing Tian, Gaili Zhang, Qunli Wu, Xiumei Huang, Yazhong Cui, Yuling Liu,Zhufang Shen, Changqing Xiao, Yingfen Qin, Heng Miao, Yongyan Zhang, Ziling Li, Shandong Ye, Xuezhi Zhang, Jing Yang, Guiwen Cao, Yi Li, Gangyi Yang, Ji Hu, Xiaoyue Wang, Zhengfang Li, Yukun Li, Xiuzhen Zhang, Guangde Zhang, Li Chen, Wenjin Hua, Ming Yu, Chunyan Lu, Xiaomei Zhang, and Hong Jiang. Diabetes Care 2021
2. Ramulus mori (sangzhi) alkaloids (sz-a) ameliorate glucose metabolism accompanied by the modulation of gut microbiota and ileal inflammatory damage in type 2 diabetic kkay mice. Quan Liu, Shuainan Liu*, Hui Cao, Wenming Ji, Caina Li, Yi Huan, Lei Lei, Yaxin Fu, Xuefeng Gao, Yuling Liu, Zhufang Shen. Frontiers in Pharmacology. 2021
3. Discovery of N‑Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6- Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X‑ray Crystal Complex Analysis. Jie Zhou, Jianbo Bie, Xiaoyu Wang, Quan Liu, Rongcui Li, Hualong Chen, Jinping Hu, Hui Cao, Wenming Ji, Yan Li, Shuainan Liu,* Zhufang Shen,* and Bailing Xu*. J. Med. Chem. 2020
4. Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and Short-Chain Fatty Acids in Spontaneous Type 2 Diabetic KKAy Mice. Hui Cao, Caina Li*, Lei Lei, Xing Wang, Shuainan Liu, Quan Liu, Yi Huan, Sujuan Sun and Zhufang Shen*. Frontiers in Pharmacology. 2020
5. Diphenyl diselenide alleviates diabetic peripheral neuropathy in rats with streptozotocin-induced diabetes by modulating oxidative stress. Xing Wang, Yi Huan, Caina Li, Hui Cao, Sujuan Sun, Lei Lei, Quan Liu, Shuainan Liu, Wenming Ji, Hongmei Liu, Kaixun Huang, Jun Zhou, Zhufang Shen. Biochemical Pharmacology. 2020
6. Histone Deacetylase 3-Selective Inhibitor RGFP966 Ameliorates Impaired Glucose Tolerance through β-Cell Protection. Lei Lei, Guoliang Bai, Xing Wang, Shuainan Liu, Jie Xia, Song Wu, Yi Huan, and Zhufang Shen.Toxicology and Applied Pharmacology. 2020
7. Pose Filter-Based Ensemble Learning Enables Discovery of Orally Active Nonsteroidal Farnesoid X Receptor Agonists. Jie Xia,∞ Zhenyi Wang,∞ Yi Huan,∞ Wenjie Xue, Xing Wang, Yuxi Wang, Zhenming Liu, Jui-Hua Hsieh, Liangren Zhang, Song Wu,* Zhufang Shen,* Hongmin Zhang,* and Xiang Simon Wang*. J. Chem. Inf. Model. 2020
8. Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice. Cai-Na Li, Xing Wang，Lei Lei，Min-Zhi Liu，Rong-Cui Li，Su-Juan Sun，Shuai-Nan Liu，Yi Huan，Tian Zhou，Quan Liu，Hui Cao，Guo-Liang Bai，Yu-Wei Han，Zhu-Fang Shen*.Phytotherapy Research. 2020
9. α 葡萄糖苷酶抑制剂桑枝总生物碱的抗糖尿病作用研究（Anti-diabetic effects of the fraction of alkaloids from Ramulus Mori, an innovative Sangzhi alkaloids as an α-glucosidase inhibitor）. 刘率男, 刘泉, 孙素娟, 李彩娜, 环奕, 陈跃腾, 汪仁芸, 夏学军, 刘志华, 刘玉玲, 谢明智, 申竹芳*（LIU Shuai-nan, LIU Quan, SUN Su-juan, LI Cai-na, HUAN Yi, CHEN Yue-teng, WANG Ren-yun, XIA Xue-jun, LIU Zhi-hua, LIU Yu-ling, XIE Ming-zhi, SHEN Zhu-fang*）药学学报（Acta Pharmaceutica Sinica）. 2019
10. A novel specific PPARγ modulator YR4-42 ameliorates hyperglycemia and dyslipidemia and hepatic steatosis in diet-induced obese mice. Yi Huan1, Xuan Pan1, Jun Peng, Chunming Jia, Sujuan Sun, Guoliang Bai, Xing Wang, Tian Zhou, Rongcui Li, Shuainan Liu, Caina Li, Quan Liu, Zhanzhu Liu*, Zhufang Shen*. Diabetes Obese Metablism. 2019
11. Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia. Anfang Cui, Heng Fan, Yinliang Zhang, Yujie Zhang, Dong Niu, Shuainan Liu, Quan Liu, Wei Ma, Zhufang Shen, Lian Shen, Yanling Liu, Huabing Zhang, Yuan Xue, Ying Cui, Qinghua Wang, Xinhua Xiao, Fude Fang, Jichun Yang, Qinghua Cui, and Yongsheng Chang. The Journal of Clinical Investigation 2019
12. Maltol, a food flavor enhancer, attenuates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats. Nan Guo, Caina Li,* Quan Liu, Shuainan Liu, Yi Huan, Xing Wang, Guoliang Bai, Miaomiao Yang, Sujuan Sun, Caimin Xu and Zhufang Shen *, Food & Function. 2018,
13. Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction. Yue Wang, Quan Liu, Yi Huan, Rongcui Li, Caina Li, Sujuan Sun, Nan Guo, Miaomiao Yang, Shuainan Liu⁎, Zhufang Shen⁎. Experimental Cell Research. 2018
14. Glutazumab, a novel long-lasting GLP-1/anti-GLP-1R antibody fusion protein, exerts anti-diabetic effects through targeting dual receptor binding sites. Caina Li, Miaomiao Yang, Xiaofeng Wang, Hua Zhang, Chenjiang Yao, Sujuan Sun, Quan Liu, Hao Pan, Shuainan Liu, Yi Huan, Shengnan Li, Jun Cao, Xing Wang, Yong Guo, Nan Guo, Shuqian Jing, Cheng Zhang, Zhufang Shen,⁎ Biochemical Pharmacology. 2018
15. The potential role of glucokinase activator SHP289-04 in anti-diabetes and hepatic protection. Lei Lei, Shuainan Liu, Yongqiang Li, Huipeng Song, Lianchao He, Quan Liu, Sujuan Sun, Yan Li, Zhiqiang Feng, Zhufang Shen. European Journal of Pharmacology 2018
16. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Yi Huan, Qian Jiang, Gang Li, Guoliang Bai, Tian Zhou, Shuainan Liu, Caina Li, Quan Liu, Sujuan Sun, Miaomiao Yang, Nan Guo, Xing Wang, Shusen Wang, Yaojuan Liu, Guanqiao Wang, Haihong Huang & Zhufang Shen. Scientific Reports .2017
17. Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and indiabetic KKAy mice. Quan Liu, Shuainan Liu, Lihui Gao, Sujuan Sun, Yi Huan, Caina Li, Yue Wang, Nan Guo, ZhufangShen. Acta Pharmaceutica Sinica B. 2017
18. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Pingping Li, Shuainan Liu, Min Lu, Gautum Bandyopadhyay, Dayoung Oh, Takeshi Imamura, Andrew M.F. Johnson, Dorothy Sears, Zhufang Shen, Bing Cui, Lijuan Kong, Shaocong Hou, Xiao Liang, Salvatore Iovino, Steven M. Watkins, Wei Ying, Olivia Osborn, Joshua Wollam, Martin Brenner, and Jerrold M. Olefsky. Cell. 2016
1. 实验药理学、编者、高等教育出版社、2021
2. 中药药效学研究方法学、编者与编委、人民卫生出版社、2016
3. 中国食用药用真菌化学、编委、上海科学技术文献出版社、2016
4. 中药药效学研究方法学、编者与编委、人民卫生出版社、2016
5. 应用分子药理学、编者、中国协和医科大学出版社、2015
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1. 1993. 治疗糖尿病新药金芪降糖片的研究. 谢明智、邵国贤、何丽一、申竹芳、马德明、刘海帆、李宝明. 卫生部科学技术进步. 三等奖.
2. 2009. 以α-葡萄糖苷酶为靶点发现和诠释中草药治疗糖尿病作用及机理. 申竹芳、陈若芸、刘玉玲、刘泉、夏学军、谢明智. 北京市科学技术. 三等奖.
3. 2009. 以α-葡萄糖苷酶为靶点发现和诠释中草药治疗糖尿病作用及机理. 申竹芳、陈若芸、刘玉玲、刘泉、夏学军、谢明智、王洪庆、汪仁芸. 中华医学会科技进步. 三等奖.
4. 2012. 桑属植物及其代谢产物的化学和生物活性基础研究. 陈若芸、于德泉、申竹芳、戴胜军、谭永霞、张庆建、刘超、刘泉. 中华医学科技奖. 三等奖.
5. 2012. 桑属植物及其代谢产物的化学和生物活性基础研究. 陈若芸、于德泉、申竹芳、谭永霞、张庆建、刘超、刘泉、戴胜军、杨燕、康洁、王洪庆、崔锡强、王磊、孙胜国、倪刚. 北京市科学技术奖. 一等奖.
6. 2013. 中草药活性物质快速识别与获取新型技术体系的建立及其在微量活性物质研究中的应用. 庾石山、石建功、张东明、于德泉、陈晓光、张建军、王珂、申竹芳、马双刚、林生. 中华医学科技奖. 二等奖.
7. 2013. 若干重要中草药中微量活性物质的研究. 庾石山、石建功、张东明、于德泉、陈晓光、张建军、王珂、申竹芳、马双刚、林生、徐嵩、李勇、屈晶、吕海宁、李创军. 北京市科学技术奖. 一等奖.
8. 2013. 中草药微量活性物质获取关键技术研究及其应用. 庾石山、石建功、张东明、于德泉、陈晓光、张建军、王珂、申竹芳、马双刚、林生、徐嵩、李勇、屈晶、吕海宁、李创军. 教育部科学技术进步奖. 二等奖.
9. 2014. 中草药微量活性物质识别与获取的关键技术及应用. 庾石山、石建功、张东明、于德泉、陈晓光、张建军、王珂、申竹芳、马双刚、屈晶. 国家科学技术进步奖.二等奖.
10. 2015. 金芪降糖片治未病（糖尿病前期）的询证研究.郭立平、商洪才、任明、王涛、邓雁如、陈莉明、王学美、王德惠、李双蕾、陈建宗、申竹芳、曹红波、张俊华等. 中国中西医结合学会科学技术奖.三等奖.
