天然药物活性物质与功能国家重点实验室

个人简介

bobapp官方下载研究员，药理室副主任。1989年毕业于河北医学院临床医学专业，2004年于协和医科大学bobapp官方中国有限公司获博士学位，2008年从美国哈佛大学医学院，Brigham and Women’s Hospital神经疾病中心回国进入bobapp官方中国有限公司工作，从事脑血管及神经精神疾病的发病机制及治疗药物的发现研究。主要针对脑疾病（急性缺血性脑卒中、脑外伤）；神经退行性疾病（阿尔茨海默病、肌萎缩性侧索硬化症）；精神疾病（焦虑症、抑郁症）研发具有自主知识产权的创新药物。先后承担了国家自然科学基金委、科技部、医科院、北京市等多项研究课题，建立了规范化的脑血管及神经精神疾病的药物研发平台。发表相关研究发表SCI论文56篇，获中国、国际专利授权19项。

研究方向

1. 脑疾病（急性缺血性脑卒中、脑外伤）的发病机制及创新药物研究。
2. 神经退行性疾病（阿尔茨海默病、肌萎缩性侧索硬化症）的发病机制及创新药物研究。
3. 精神疾病（焦虑症、抑郁症）的发病机制及创新药物研究。

发表论文

1. ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis. Tang JS, Kang YY, Zhou YJ, Li XN, Wu L, Feng XH*, Peng Y*. Neurobiol Dis. 2021.
2. Neuroprotective effects of Hemocoagulase Agkistrodon on experimental traumatic brain injury. Tang JS, Kang YY, Huang LJ, Feng XH, Wu L, Peng Y*. Brain Res Bull. 2021.
3. L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer’s disease mouse model and cultured hippocampal neurons. Huang LJ, Lan JQ, Tang JS, Kang YY, Feng XH, Wu L, Peng Y*. Mol Neurobiol. 2021.
4. Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases. Li XN, Huang LJ, Lan JQ, Feng XH, Li PP, Peng Y*. Pharmacol Res. 2021.
5. Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2 Related Factor 2 (Nrf2) Protein−Protein Interaction. Zhang Y, Shi ZY, Zhou YJ, Xiao Q, Wang HY, Peng Y*. J Med Chem. 2020.
6. TIMP1 preserves the blood brain barrier through interacting with CD63/integrin b1 complex and regulating downstream FAK/RhoA signaling. Tang JS, Kang YY, Huang LJ, Wu L, Peng Y*. Acta Pharmaceutica Sinica B. 2020.
7. Protective effect of potassium 2-(l-hydroxypentyl)-benzoate on hippocampal neurons, synapses and dystrophic axons in APP/PS1 mice. Huang L, Zhang Y, Peng Y, Zhao Z, Zhou Y, Wang X*, Peng Y*. Psychopharmacology (Berl). 2019.
8. Protective effects of L-3-n-butylphthalide against H2O2-induced injury in Neural Stem Cells by activation of PI3K/Akt and Mash1 pathway. Wang S, Huang L, Zhang Y, Peng YC, Wang XL*, Peng Y*. Neuroscience 2018.
9. Hsp90β inhibitors prevent GLT-1 degradation but have no beneficial efficacy on absence epilepsy. Peng YC, Wang S, Zhang Y, Huang L, Wang XL*, Peng Y*. J Asian Nat Prod Res. 2018.
10. From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Huang L, Wang S, Ma F, Zhang Y, Peng Y, Xing C, Feng Y, Wang X*, Peng Y*. Pharmacol Res. 2018.
11. Dl-3-n-Butylphthalide: A Promising Therapeutic Agent for Ischemic Stroke. Wang S, Ma Fa, Huang L, Zhang Y, Peng YC, Xing CH, Feng YP, Wang XL*, Peng Y*. CNS & Neurological Disorders-Drug Targets. 2018.
12. L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Lei H, Zhang Y, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X*, Peng Y*. Neurotox Res. 2018.
13. DL-3-n-Butylphthalide reduces atrial fibrillation susceptibility by inhibiting atrial structural remodeling in rats with heart failure. Qiu H, Wu H, Ma J, Cao H, Huang L, Qiu W, Peng Y*, Ding C*. Naunyn Schmiedebergs Arch Pharmacol. 2018.
14. Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Zhao CY, Hou WZ, Lei H, Huang LJ, Wang S, Cui DD, Xiang CH, Wang XL*, Peng Y*. Acta Pharmaceutica Sinica B. 2017.
15. Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer’s Disease. Li L, Xu SF, Liu LF, Feng RT, Gong YX, Zhao XY*, Li J, Cai J, Feng N, Wang L, Wang XL*, Peng Y*. J Alzheimers Dis. 2017.
16. Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase. Wang R, Chen R, Li J, Liu X, Xie K, Chen D, Peng Y*, Dai J*. J Nat Prod. 2016.
17. L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease. Zhang Y, Huang LJ, Shi S, Xu SF, Wang XL*, Peng Y*. CNS Neurosci Ther. 2016.
18. DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model. Wang F, Ma J, Han F, Guo X, Meng L, Sun Y, Jin C, Duan H, Li H*, Peng Y*. Sci Rep. 2016.
19. L-3-n-butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and up-regulates Heme oxygenase-1 in lipopolysaccharide-treated mice. Zhao CY Lei H, Zhang Y, Li L, Xu SF, Cai J, Wang XL*, Peng Y*. J Asian Nat Prod Res. 2016.
20. L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity After Focal Cerebral Ischemia in Rats. Yang LC, Li J, Lei H, Liu DM, Zhang M, Rong XF, Wang L, Peng Y*, Wang XL*. CNS Neurosci Ther. 2015.

专著

1. 《应用分子药理学》，编委，中国协和医科大学出版社，2015.
2. 《药理学研究的新技术与新方法》，编委，中国协和医科大学出版社，2014.
3. 《药理学研究的新思路与新靶点》，编委，中国协和医科大学出版社，2012.
4. 《现代药理实验方法》，编委，中国协和医科大学出版社，2012.

专利

1. 2-(α-羟基戊基)苯甲酸盐及其制法和用途. 杨靖华,王晓良,徐志斌,彭英. 授权号： ZL01109795.7（中国）、756470（韩国）、2305092（俄罗斯）、7550507（美国）、2186792（欧洲）、60247646.1（德国）、31341BE/2009（意大利）、ID P0025270（印尼）、2485479（加拿大）、164845（以色列）、5058439（日本）、289184（印度）、PI0215777-2（巴西）.
2. 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用. 冯亦璞,王晓良,杨靖华,彭英. 授权号：0860703（韩国）、2336870（俄罗斯）、2004279655（澳大利亚）、122537（新加坡）、I393562（台湾）.
3. 左旋正丁基苯酞在制备预防或治疗痴呆的药物中的用途. 冯亦璞,王晓良,彭英,杨靖华. 授权号：ZL03137457.3（中国）、I419686（台湾）.
4. 一类杭白菊提取的化合物、其药物组合物及其在防治神经退行性疾病中的应用. 张培成,王晓良,杨鹏飞,彭英,杨桠楠,王珊,冯子明,姜建双. 授权号：ZL20161120409545.
5. 一种治疗阿尔茨海默病的缓释制剂及其制备方法. 王晓良,高钟镐,黄伟,王琰,黄海洪,彭英,辛欣,郭芳,冯茹. 授权号：ZL2018103058498.
6. 含 5-取代四氢异喹啉的丙酸类化合物、其药物组合物和应用. 石泽玉,肖琼,彭英,张泳,兰嘉琦,扈金萍,胡民万,尹大力. 申请号：202011286007.6.
7. TIMP-1在制备预防或治疗创伤性脑损伤药物中的应用. 彭英,唐婧姝,康钰莹,黄龙舰. 申请号：201910852472.2.
8. 一类A环具有葡萄糖的醌式二氢查尔酮双碳苷化合物,制法与神经保护活性. 张培成,彭英,高万,杨桠楠,姜建双,冯子明,周昱君. 申请号：201910165010.3.
9. 一类来源于川芎的化合物,其制法及在抗脑缺血损伤方面的应用. 张培成,王晓良,张旭,彭英,杨桠楠,冯子明,黄龙舰,姜建双. 申请号：2017102618144

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