杨敏研究员2016年作为引进人才到bobapp官方下载
工作,负责生物分析中心平台管理、科研及教学工作。2007年毕业于北京大学,获医学博士学位。美国匹兹堡大学医学中心访问学者。入选北京市科技新星,北京市卫生系统高层次人才学科骨干。担任国家卫健委全国老龄健康专家库成员,全国研究生教育评估监测专家库专家,中国国家留学基金委员会评审专家,ICH非临床安全性试验专家组成员,中关村NMT产业联盟项目评审专家,北京药理学会会员代表,国家自然科学基金、北京市自然科学基金函审专家。担任中国研究型医院学会生物标志物专业委员会常务委员,中国药理学会生化与分子药理学专业委员会委员,《中国误诊学杂志》编委,国际免疫学会联合会官方期刊Frontiers in Immunology评审编辑。
迄今作为项目负责人主持国家自然科学基金面上项目4项、北京市级科研纵向基金3项、院校级基金3项;主持企业及事业单位委托的横向课题117项。获得美国华裔心脏病协会基础研究一等奖,西安市科学技术二等奖。担任北京协和医学院研究生课程《实验病理学技术》课程负责人,作为常务编委参编研究生教材《药理学实验操作教程》,获得药物所第七届教师教学基本功比赛二等奖,指导的研究生多次获得“国家奖学金”、“一等学业奖学金”及“北京协和医学院优秀研究生”称号。
目前发表论文40余篇,第一及独立通讯作者的SCI论著20篇,代表性成果已发表在Cell Death & Differentiation,Molecular Cancer,Arteriosclerosis Thrombosis & Vascular Biology,Cell Death & Disease,BBA-Molecular Basis of Disease,Acta Pharmacologica Sinica,Frontiers in Immunology等著名学术期刊。作为第一发明人申报国家发明专利6项,授权专利1项。主持建立的“药效物质发现及药效评价创新技术体系”通过技术服务和开发转化赋能多家知名药企新药创制,取得良好的经济效益和社会价值。
近五年作为项目负责人主持的纵向及部分横向科研项目
1.国家自然科学基金面上项目:趋化因子CCL5促进血小板活化介导高血压导致心脏纤维化的机制研究,2020.1-2023.12,65万元,NO.81973325,在研
2.中国医学科学院医学与健康科技创新工程:天然药物中未知小分子药效物质发现与评价新技术研究,子课题,2021.10-2025.12,85万元,2021-I2M-1-028,在研
3.国家自然科学基金面上项目:SEMA6A下调PLGF抑制肿瘤相关巨噬细胞M2型极化抗结直肠癌肝脏转移的机制研究,2018.1-2021.12,60万元,NO.81773750,结题
4.国家自然科学基金面上项目:SGK1通过激活NLRP3炎症小体介导急性心肌梗死后心脏损伤的机制研究,2015.1-2018.12,73万元,NO.81470431,结题
5.北京协和医学院教师课程思政教学改革项目:探索实验病理学技术课程融入思政教育提升药学研究生综合素质,2021.9-2022.9,2万元,NO.2021KCS20128,结题
6.bobapp官方下载
引进人才启动经费:实验病理学技术平台建设,2016.10-2021.10,70万元,结题
7.企业横向课题:结直肠癌诊断及预后生物标志物研究,2022.4-2023.4,30万元,结题
8.企业横向课题:间充质干细胞改善肝硬化临床前药效学研究,2022.9-2026.9,51万元,在研
9.企业横向课题:间充质干细胞改善心力衰竭临床前药效学研究,2022.9-2026.9,77万元,在研
10.企业横向课题:间充质干细胞改善狼疮性肾炎临床前药效学研究,2022.9-2025.9,37万元,在研
11.企业横向课题:基于REOA算法筛选肺癌诊断与预后相关miRNA基因对研究,2023.4-2025.3,15万元,在研
肿瘤预后及免疫治疗新靶标、生物信息学、防治心血管疾病靶点及新药研究、天然产物药效及药理机制研究
近五年以独立通讯作者发表的SCI论著
[1] Rixin Zhang, Wenqiang Gan, Jinbao Zong, Yufang Hou, Mingxuan Zhou, Zheng Yan, Tiegang Li, Silin Lv, Zifan Zeng, Weiqi Wang, Fang Zhang, Min Yang*. Developing an m5C regulator-mediated RNA methylation modification signature to predict prognosis and immunotherapy efficacy in rectal cancer. Frontiers in Immunology. 2023. DOI: 10.3389/fimmu.2023.1054700 (IF: 8.786)
[2] Mingxuan Zhou, Silin Lv, Yufang Hou, Rixin Zhang, Weiqi Wang, Zheng Yan, Tiegang Li, Wenqiang Gan, Zifan Zeng, Fang Zhang, Min Yang*. Characterization of sialylation-related long noncoding RNAs to develop a novel signature for predicting prognosis, immune landscape, and chemotherapy response in colorectal cancer. Frontiers in Immunology. 2022. DOI: 10.3389/fimmu.2022.994874 (IF: 8.786)
[3] Yufang Hou, Rixin Zhang, Jinbao Zong, Weiqi Wang, Mingxuan Zhou, Zheng Yan, Tiegang Li, Wenqiang Gan, Silin Lv, Zifan Zeng, Min Yang*. Comprehensive analysis of a cancer-immunity cycle–based signature forpredicting prognosis and immunotherapyresponse in patients with colorectal cancer. Frontiers in Immunology. 2022. DOI: 10.3389/fimmu.2022.892512 (IF: 8.786)
[4] Tiegang Li, Weiqi Wang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Zheng Yan, Rixin Zhang, Min Yang*. Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy. Aging-US; 2022. 14(3): 1508-1528. (IF: 5.955)
[5] Wenqiang Gan, Weiqi Wang, Tiegang Li, Rixin Zhang, Yufang Hou, Silin Lv, Zifan Zeng, Zheng Yan, Min Yang*. Prognostic values and underlying regulatory network of Cohesin subunits in esophageal carcinoma. Journal of Cancer; 2022. 13(5): 1588-1602. (IF: 4.478)
[6] Silin Lv, Zifan Zeng, Wenqiang Gan, Weiqi Wang, Tiegang Li, Yufang Hou, Zheng Yan, Rixin Zhang, Min Yang*. Lp-PLA2 inhibition prevents Ang II–induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation. Acta Pharmacologica Sinica; 2021.42(12): 2016-2032. (IF:7.169)
[7] Tiegang Li#, Zheng Yan#, Weiqi Wang, Rixin Zhang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Min Yang*. SEMA6B overexpression predicts poor prognosis and correlates with the tumor immunosuppressive microenvironment in colorectal cancer. Frontiers in Molecular Biosciences. 2021. DOI: 10.3389/fmolb.2021.687319 (IF: 6.113)
[8] Yufang Hou#, Weiqi Wang#, Zifan Zeng#, Wenqiang Gan, Silin Lv, Tiegang Li, Zheng Yan, Rixin Zhang, Min Yang*. High SEMA4C expression promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal carcinoma. Aging-US; 2020. 12(21): 21992-22018. (IF: 5.682)
[9] Rixin Zhang, Tiegang Li, Weiqi Wang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Zheng Yan, Min Yang*. Indoleamine 2, 3-dioxygenase 1 (IDO1) and CD8 expression profiling revealed an immunological subtype of colon cancer with a poor prognosis. Frontiers in Oncology; 2020. 10:594098. DOI: 10.3389/fonc.2020.594098 (IF: 6.244)
[10] Weiqi Wang, Silin Lv, Wenqiang Gan, Zifan Zeng, Min Yang*. A bioinformatics analysis on the potential role of ACE2 in cardiac impairment of patients with coronavirus disease 2019. Annals of Translational Medicine; 2020. 8(21): 1403. DOI: 10.21037/atm-20-2755 (IF: 3.932)
[11] Yufang Hou, Tiegang Li, Wenqiang Gan, Silin Lv, Zifan Zeng, Zheng Yan, Weiqi Wang, Min Yang*. Prognostic significance of mutant-allele tumor heterogeneity in uterine corpus endometrial carcinoma. Annals of Translational Medicine; 2020. 8(6):339. DOI: 10.21037/atm.2020.02.136. (IF: 3.932)
[12] Wenqiang Gan#, Jingyuan Ren#, Tiegang Li, Silin Lv, Chenghe Li, Ziliang Liu, Min Yang*. The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. Biochimica et Biophysica Acta-Molecular Basis of Disease; 2018. 1864(1):1-10. (IF: 4.328)