科研队伍

bobapp官方下载 药理学博士,曾在美国加州大学圣迭戈分校做博士后,并在美国加州大学圣迭戈分校先后任项目科学家和助理教授。2015年回国后在bobapp官方下载 建立实验室,现为在bobapp官方下载 研究员和博士生导师。2015年获得协和学者特聘教授称号;2016年入选国家级优秀青年人才项目;2016年入选国家自然基金委优秀青年;2017年入选求是杰出青年科学家。2018年入选北京高校“卓越青年”科学家,2020年获得第七届“树兰医学奖”。现任中国医学科学院代谢紊乱和肿瘤发生相关机制和靶点发现重点实验室主任,中国医学科学院北京协和医学院学术委员会委员,中国药学会青年委员会委员,北京市侨联青年委员会委员,北京生理科学会理事,中国医学科学院青年科学家联盟理事,卫生健康青年创新中心第一届青年导师团导师,《药学学报》和《Metabolism Open》 编委。致力于肥胖、胰岛素抵抗及糖尿病发生的分子免疫学机制研究。累计发表SCI论文70余篇,引用5000余次。主要研究工作 (通讯作者或第一作者)发表在Cell(3篇)、Nature Medicine、Cell Metabolism、Nature metabolism、Hepatology、Nature communications、PNAS 和Diabetes 等期刊。

肥胖及代谢性疾病发病新机制、新药靶和原创新药研发。

1. Xingfeng Liu, Kai Wang, Shaocong Hou, Qian Jiang, Chunxiao Ma, Qijin Zhao, Lijuan Kong, Jingwen Chen, Zhenhe Wang, Huabing Zhang, Tao Yuan, Yuxiu Li, Yi Huan, Zhufang Shen, Zhuowei Hu, Zhifeng Huang, Bing Cui and Pingping Li*. Insulin induces insulin receptor degradation in the liver through EphB4. Nature Metabolism. 2022, 4(9):1202-1213. PMID: 36131205
2. Xingfeng Liu, Kai Wang, Luhai Wang, Lijuan Kong, Shaocong Hou, Yanjun Wan, Chunxiao Ma, Jingwen Chen, Xiaowei Xing, Caiyi Xing, Qian Jiang, Qijin Zhao, Bing Cui, Zhifeng Huang*, Pingping Li*. Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity. Hepatology. 2022, doi: 10.1002/hep.32708. Online ahead of print. (* co-corresponding author) PMID: 35931467
3. Lei Ying, Luyao Wang, Kaiwen Guo, Yushu Hou, Na Li, Shuyi Wang, Xingfeng Liu, Qijin Zhao, Jie Zhou, Longwei Zhao, Jianlou Niu, Chuchu Chen, Lintao Song, Shaocong Hou, Lijuan Kong, Xiaokun Li, Jun Ren, Pingping Li*, Moosa Mohammadi* & Zhifeng Huang*. Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects. Nature Communications. 2021,12:7256. (* co-corresponding author) PMID: 34907199
4. Johnson, A. M. F., Hou, S., and Li, P. (2017) Inflammation and insulin resistance: New targets encourage new thinking: Galectin-3 and LTB4 are pro-inflammatory molecules that can be targeted to restore insulin sensitivity. Bioessays. 39 (9) PMID: 28752547
5. Li PP*, Liu SN, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson, A.M.F., Sears D, Shen ZF, Cui B, Kong LJ, Hou SC, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM*. Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016. 167(4):973-984.e12 (Lead Contact, * co-corresponding author) PMID: 27814523
6. Li P*, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A,Chung H, Mayoral R, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM*. LTB4promotes insulin resistance in obese mice by acting on macrophages, hepatocytesand myocytes. Nat Med. 2015; 21(3): 239-47. (* co-corresponding author) PMID: 25706874.
7. Li, P. *, Spann, N.*, Kaikkonen, M., Lu, M., Oh, D., Fox, J., Bandyopadhyay, G., Talukdar, S., Xu, J., Lagakos, W., Patsouris, D., Armando, A., Quehenberger, O., Dennis, E., Watkins, S., Auwerx, J., Glass, C., Olefsky, J. NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids. Cell. 2013; 155, 200-214. (* co-first author) PMID: 24074869
8. Baeza-Raja B, Li PP*, D. Sachs B, Davalos D, Eirini Vagena, Schachtrup C, Loucks FA, Sikorski S, Helmrick M, Le Moan N, Bridges D, Tsigelny I, Baron LJ, Wynshaw-Boris. Anthony, Miriam Scadeng, Saltiel AR, Olefsky JM, Akassoglou K: p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012; 109(15):5838-43 (* co-first author) PMID: 22460790
9. Li PP, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM: Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell. 2011;147:815-826. PMID: 22078880
10. Lee YS, Li PP*, Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB: Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes. 2011;60:2474-2483. (* co-first author). PMID: 21911747
11. Li PP, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM: Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. 2010;285:15333-15345. PMID: 20308074
12. Lu M, Li PP*, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM: Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010;24:1413-1422. (* co-first author). PMID: 20444886
13. Patsouris D, Li PP*, Thapar D, Chapman J, Olefsky JM, Neels JG: Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008;8:301-309. (* co-first author). PMID: 18840360
14. Li PP, Shan S, Chen YT, Ning ZQ, Sun SJ, Liu Q, Lu XP, Xie MZ, Shen ZF: The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Br J Pharmacol. 2006;148:610-618. PMID: 16751799
15. Shuang Shang, Yu-Wei Yang, Fei Chen, Liang Yu, Shuo-Hao Shen, Ke Li, Bing Cui, Xiao-Xi Lv, Cheng Zhang, Chen Yang, Jing Liu, Jiao-Jiao Yu, Xiao-Wei Zhang, Ping-Ping Li, Sheng-Tao Zhu, Hai-Zeng Zhang, Fang Hua*. TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer. Science Translational Medicine. 2022, 14(626):eabf0992. PMID: 34985967
16. Hui-Min Cheng, Mingming Xing, Ya-Ping Zhou, Weitao Zhang, Zeyu Liu, Lan Li, Zuguo Zheng, Yuanchen Ma, Pingping Li, Xiaoxuan Liu, Ping Li and Xiaojun Xu. HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling. Cell Death & Differentiation. 2023 Mar;30(3):673-686. PMID: 36198833
17. Shanshan Liu*, Xiaoxi Lv, Xupeng Wei, Chang Liu, Qiao Li, Jiali Min, Fang Hua, Xiaowei Zhang, Ke Li, Pingping Li, Yang Xiao, Zhuowei Hu, Bing Cui*. TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target. Acta Pharm Sin B. 2021,11(10):3105-3119. PMID: 34729304
18. Shan-shan Liu, Chang Liu, Xiao-xi Lv, Bing Cui, Jun Yan, Yun-xuan Li, Ke Li, Fang Hua, Xiao-wei Zhang, Jiao-jiao Yu, Jin-mei Yu, Feng Wang, Shuang Shang, Ping-ping Li, Zhi-guang Zhou, Yang Xiao* and Zhuo-wei Hu. The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity. 2021,54(10):2433-2435. PMID: 34644559
19. Shan-shan Liu, Chang Liu, Xiao-xi Lv, Bing Cui, Jun Yan, Yun-xuan Li, Ke Li, Fang Hua, Xiao-wei Zhang, Jiao-jiao Yu, Jin-mei Yu, Feng Wang, Shuang Shang, Ping-ping Li, Zhi-guang Zhou, Yang Xiao* and Zhuo-wei Hu*. The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity. 2021,54(9):2042-2056. PMID: 34407391
20. Caina Li*, Hui Cao, Yi Huan, Wenming Ji, Shuainan Liu, Sujuan Sun, Quan Liu, Lei Lei, Minzhi Liu, Xuefeng Gao, Yaxin Fu, Pingping Li, Zhufang Shen*. Berberine combined with stachyose improves glycometabolism and gut microbiota through regulating colonic microRNA and gene expression in diabetic rats. Life Sci. 2021,284:119928. PMID: 34480937
21. Zhang L, Yang SY, Qi-Li FR, Liu XX, Zhang WT, Peng C, Wu P, Li P, Li P, Xu X. Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis. Phytother Res. 2021,35(7):3898-3915. PMID: 33860590
22. Chifa Ma*, Yiwen Liu, Shuli He, Jingbo Zeng, Pingping Li, Chunxiao Ma, Fan Ping, Huabing Zhang, Lingling Xu, Wei Li, Yuxiu Li*. Association between glucose fluctuation during 2-hour oral glucose tolerance test, inflammation and oxidative stress markers, and β-cell function in a Chinese population with normal glucose tolerance. Ann Transl Med. 2021,9(4):327. PMID: 33708954
23. Chifa Ma, Yiwen Liu, Shuli He, Jingbo Zeng, Pingping Li , Chunxiao Ma, Fan Ping , Huabing Zhang , Lingling Xu, Wei Li , Yuxiu Li. Association Between Leukocyte Mitochondrial DNA Copy Number and Non-alcoholic Fatty Liver Disease in a Chinese Population Is Mediated by 8-Oxo-2'-Deoxyguanosine. Front Med (Lausanne). 2020;7:536. PMID: 33015093

1. 李平平,侯少聪,于恒彩 等. 肠道上皮细胞核受体抑制子NCoR作为靶标在治疗肥胖和糖尿病药物或生物制剂中的应用,发明专利,专利号PCT/CN2022/098294, 申请日2022年6月12日
2. 李平平,万彦军,崔冰 等. 迪拉马尼在制备预防和/或治疗矽肺疾病药物中的应用,发明专利,专利号202210831062.1, 申请日2022年7月15日
3. 李平平,万彦军,崔冰 等. 炎琥宁在制备预防和/或治疗矽肺疾病药物中的应用,专利号202210832685.0, 申请日2022年7月15日
4. 李平平,柳星峰,崔冰 等. EphB4作为靶标在筛选增加胰岛素敏感性药物或模型中的应用,发明专利,专利号PCT/CN2020/141441,申请日2020年12月30日
5. 李平平,马春晓,崔冰 等. 一种临床评估胰岛β功能的分子标志物,发明专利,专利号202111065268.X,申请日2021年09年12日
6. 李平平,万彦军,崔冰 等. 迪拉马尼在制备预防和或治疗肺损伤及肺纤维化药物中的应用, 发明专利,专利号2021113208031,申请日2021年11年09日
7. 李平平,吉腾飞,万彦军 等. 11-羰基-β-乙酰乳香酸治疗肺损伤及肺纤维化的应用,发明专利,专利号2021113196674,申请日2021年11年09日
8. 李平平,吉腾飞,万彦军 等. 炎琥宁在制备预防和/或治疗肺损伤及肺纤维化药物中的应用,发明专利,专利号2021113268494,申请日2021年11年10日
9. 李平平,万彦军,崔冰 等. 水溶性维生素E预防或治疗肺损伤及肺纤维化的用途, 发明专利,专利号2021113208027,申请日2021年11月09日吉腾飞,李平平,马春晓,王佳佳,崔冰,万彦军,李鹤,王洪建. 乳香酸类化合物作为 LTB4 受体抑制剂的用途,中国专利申请号:202110277275.X,申请日:2021年03月15日。
10. 吉腾飞,李平平,万彦军,崔冰,赵其锦,王洪建,王佳佳. 穿心莲内酯作为LTB4受体抑制剂的医药用途,中国专利申请号:202110275769.4. 申请日:2021年03月15日。
11. 李平平,吉腾飞,马春晓,崔冰,柳星峰,朱婷婷,王洪建. 穿心莲新苷作为LTB4受体抑制剂的医药用途, 中国专利申请号:202110277253.3. 申请日:2021年03月15日。
12. 李平平,吉腾飞,崔冰,王洪建,万彦军,孔丽娟,赵其锦,王佳佳. 竹红菌素类化合物作为LTB4受体抑制剂的医药用途,中国专利,申请号:202110277286.6. 申请日:2021年03月15日。
13. 李平平,侯少聪,于恒彩,崔冰,柳星峰,姜茜,孔丽娟,马春晓,赵其锦. 肠道上皮细胞核受体抑制子NCoR作为靶标在治疗肥胖和糖尿病药物或生物制剂中的应用,中国专利申请号:202011436116.1,申请日:2020年12月10日。
14. 李平平,孔丽娟,赵其锦,姜茜,崔冰,柳星峰,马春晓,侯少聪. FMO3作为靶标在筛选防治胰岛功能损伤药物或模型中的应用,中国专利,申请号:202010883988.6,申请日:2020年8月28日
15. 李平平,姜茜,崔冰,赵其锦,柳星峰,马春晓,王树森,孔丽娟,侯少聪. Galectin-3作为靶标在寻找保护胰岛功能药物或者生物制剂中的应用,中国专利申请号:202010292382.5,申请日2020年4月14日
16. 李平平,马春晓,柳星峰,崔冰,姜茜,孔丽娟,侯少聪. 用于人Galectin-3含量检测的ELISA荧光检测试剂盒, 中国专利,申请号:202010188662.1,申请日:2020年3月17日
17. 李平平,柳星峰,崔冰,王凯,陈婧文,侯少聪,孔丽娟,姜茜,马春晓. EphB4作为靶标在筛选增加胰岛素敏感性药物或模型中的应用,中国专利,申请号:202010188663.6,申请日:2020年3月17日

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