教育及工作经历
2002/09 – 2006/07:沈阳药科大学 基础药学理科基地班 学士
2006/09 – 2011/07:北京协和医学院&bobapp官方下载
药理室 博士
2011/08至今:bobapp官方下载
药理室 助理研究员、副研究员
作为实验负责人完成多个生物1类新药的临床前药效学研究和资料申报,参与中药创新药物桑枝总生物碱片的研究;主持国家自然科学基项目2项、教育部高等学校博士点新教师类项目1项、药物所基本科研业务费项目1项;现任《中国临床药理学杂志》首届千人新苗青年委员会青年委员和中国药理学会肾脏药理专委会第二届委员;工作以来作为主要研究人员参与医科院重大协同创新项目、十三五国家科技重大专项等课题。以第一作者和通讯作者发表论文16篇(SCI论文10篇),申请专利11项(4项授权)。
主要从事抗糖尿病及其并发症的药物研发和作用机制研究。药物研发方面,主要从事多种靶点的抗糖尿病及并发症(肾脏、周围神经)药物的药理活性评价和临床前药效学研究,包括口服肽类药物研发,研究靶点如GLP-1、PCSK9、Insulin等;作用机制方面,主要挖掘GLP-1、肠道菌群等调控机体糖代谢的具体机制。
1. Caina Li#*, Quan Liu#, Wenming Ji, Yaxin Fu, Hui Cao, Yi Huan, Lei Lei, Xuefeng Gao, Leilei Chen, Cunyu Feng, Lin Zhang, Pingping Li, Yuling Liu, Shuainan Liu*, Zhufang Shen. New anti-diabetic drug Morus alba L. (Sangzhi) alkaloids (SZ-A) improves diabetic nephropathy through ameliorating inflammation and fibrosis in diabetic rats. Frontiers in Medicine, 2023 10:1164242
2. Caina Li*, Hui Cao, Yi Huan, Wenming Ji, Shuainan Liu, Quan Liu, Lei Lei, Minzhi Liu, Xuefeng Gao, Yaxin Fu, Pingping Li, Zhufang Shen*. Berberine combined with stachyose improves glycometabolism and gut microbiota through regulating colonic microRNA and gene expression in diabetic rats. Life Sci. 2021, 284: 119928
3. Caina Li, Xing Wang, Lei Lei, Minzhi Liu, Rongcui Li, Sujuan Sun, Shuainan Liu, Yi Huan, Tian Zhou, Quan Liu, Hui Cao, Guoliang Bai, Yuwei Han, Shen Zhufang*. Berberine combined with stachyose induces better glycometablism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice. Phytother Res, 2020, 34(5): 1166-1174
4. Hui Cao#, Caina Li#*, Lei Lei, Xing Wang, Shuainan Liu, Quan Liu, Yi Huan, Sujuan Sun, Shen Zhufang*. Stachyose improves the effects of berberine on glucose metabolism by regulating intestinal microbiota and short-chain fatty acids in spontaneous type 2 diabetic KKAy mice. Front Pharmacol, 2020, 11: 578943
5. Li Caina, Wang Xing, Sujuan Sun, Shuainan Liu, Yi Huan, Rongcui Li, Quan Liu, Hui Cao, Lei Lei, Minzhi Liu, Shen Zhufang *. Effects of a ready-to-eat cereal formula powder on glucose metabolism, inflammation, and gut microbiota in diabetic db/db mice. Food Sci Nutr., 2020, 8(8): 4523-4533
6. 李彩娜,刘率男,刘泉,环奕,孙素娟,申竹芳. 注射用重组艾塞那肽-人血清白蛋白融合蛋白E2HSA对小鼠胰岛β细胞功能的保护作用. 药学学报,2020,55 (6): 1175-1181
7. 郭楠,李彩娜*,张艳霞,刘宏锐,申竹芳,韩冰. 基于Nrf2/ARE信号通路改善糖尿病周围神经病变的中药有效成分的研究进展. 中国临床药理学杂志,2020, 36 (22): 3838-3844
8. 张军#,李彩娜#,程歆琦#,高凤芝,蒋玲敏,李铭,李怡,王玉洁,刘玉玲,申竹芳. 血红蛋白毛细管采集系统贮存血样用于测定糖化血红蛋白的稳定性研究. 中国临床药理学杂志. 2019, 35(6): 567-570
9. Caina Li, Miaomiao Yang, Xiaofeng Wang, Hua Zhang, Chenjiang Yao, Sujuan Sun, Quan Liu, Hao Pan, Shuainan Liu, Yi Huan, Shengnan Li, Jun Cao, Xing Wang, Yong Guo, Nan Guo, Shuqian Jing, Cheng Zhang*, Zhufang Shen*. Glutazumab, a novel long-lasting GLP-1/anti-GLP-1R antibody fusion protein, exerts anti-diabetic effects through targeting dual receptor binding sites. Biochemical Pharmacology, 2018, 150: 46-53
10. Nan Guo, Caina Li*, Quan Liu, Shuainan Liu, Yi Huan, Xing Wang, Guoliang Bai, Miaomiao Yang, Sujuan Sun, Caimin Xu, Zhufang Shen*. Maltol, a food flavor enhancer, attenuates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats. Food and Function. 2018, 9: 6287- 6297
11. Caina Li#, Miaomiao Yang#, Guojiang Hou, Shuainan Liu, Yi Huan, Dongan Yu, Sujuan Sun, Quan Liu, Shousheng Yan, Zhufang Shen. A human glucagon-like peptide-1-albumin recombinant protein with prolonged hypoglycemic effect provides efficient and beneficial control of glucose metabolism in diabetic mice. Biol. Pharm. Bull., 2017, 40: 1399-1408
12. Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu, Zhufang Shen. The albumin-exendin-4 recombinant protein E2HSA improves glycemic control and β-cell function in spontaneous diabetic KKAy mice. BMC Pharmacology and Toxicology, 2017, 18: 48-56
13. Guojiang Hou#, Caina Li#, Yi Huan, Shuainan Liu, Quan Liu, Minzhi Liu, Zhufang Shen. The PI3K/Akt1-FoxO1 translocation pathway mediates Exf effects on NIT-1 cell survival. Exp Clin Endocrinol Diabetes., 2017, 125: 669-676
14. 李彩娜,侯少聪,孙素娟,刘率男,姜茜,刘泉,申竹芳. E2HSA对老龄肥胖小鼠糖脂代谢和β细胞功能的影响.中国新药杂志. 2017, 26(1): 44-50
15. 李彩娜,孙素娟,申竹芳. 重氮化法测定小鼠血清对乙酰氨基酚浓度及其在评价胃排空功能中的应用. 药学学报. 2015, 50(5): 560-564
16. 李彩娜,孙素娟,刘率男,刘泉,申竹芳. 国产门冬胰岛素注射液在正常动物中降血糖作用的评价.中国糖尿病杂志. 2014, 22(4): 364-367
17. Xing Wang, Caina Li, Yi Huan, Hui Cao, Sujuan Sun, Lei Lei, Quan Liu, Shuainan Liu, Wenming Ji, Kaixun Huang, Zhufang Shen*, Jun Zhou*. Diphenyl diselenide ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats via suppressing oxidative stress and inflammation. Chemico-Biological Interactions. 2021, 338: 109427.
18. Xing Wang, Yi Huan, Caina Li, Hui Cao, Sujuan Sun, Lei Lei, Quan Liu, Shuainan Liu, Wenming Ji, Hongmei Liu, Kaixun Huang, Jun Zhou*, Zhufang Shen*. Diphenyl diselenide alleviates diabetic peripheral neuropathy in rats with streptozotocin-induced diabetes by modulating oxidative stress. Biochemical Pharmacology 2020, 182: 114221.
19. 周甜, 李彩娜, 环奕, 刘率男, 刘泉, 孙素娟, 李荣翠, 潘璇, 刘站柱, 申竹芳*. 新型G蛋白偶联受体40激动剂SZZ15-11的抗糖尿病作用及机制初探. 中国临床药理学杂志. 2019, 35(8): 780-784.
20. 王星,李彩娜,申竹芳*. 黄芩素对糖尿病周围神经病变保护作用机制研究进展. 中国临床药理学杂志. 2018, 34:70-73
21. 韩雨薇,李彩娜,环奕,孙素娟,穆永钊,申竹芳*. 小檗碱配伍水苏糖对糖尿病小鼠糖脂代谢及肠道菌群的影响. 中国临床药理学杂志. 2016, 32(12): 1121-1124
22. Shaocong Hou, Caina Li, Yi Huan, Shuainan Liu, Quan Liu, Sujuan Sun, Qian Jiang, Chuming Jia, Zhufang Shen*. Effects of E2HSA, a long-acting Glucagon like peptide-1 receptor agonist, on glycemic control and beta cell function in spontaneous diabetic db/db mice. Journal of Diabetes Research. 2015, 2015: 817839
23. Lixia Ji, Caina Li, Ning Shen, Yi Huan, Quan Liu, Shuainan Liu, Zhufang Shen*. A simple and stable galactosemic cataract model for rats. Int J Clin Exp Med., 2015, 8(8): 12874-12881
24. Jinglong Liu, Yi Huan, Caina Li, Minzhi Liu, Zhufang Shen*. Establishment of a selective evaluation method for DPP4 inhibitors based on recombinant human DPP8 and DPP9 proteins. Acta Pharmaceutica Sinica B., 2014, 4(2): 135-140
25. Zhiyu Chen, Shuainan Liu, Caina Li, Sujuan Sun, Quan Liu, Lei Lei, Lihui Gao, Zhufang Shen*. Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress. Lipids in Health and Disease., 2014, 13: 98-107
26. Guojiang Hou, Caina Li, Shuainan Liu, Yi Huan, Quan Liu, Sujuan Sun, Linyi Li, Shaocong Hou, Zhufang Shen*. Long-term treatment with Exf, a peptide, analog of Exendin-4, improves β-cell function and survival in diabetic KKAy mice. Peptides, 2013, 40: 123-132
1. 《药理学实验操作教程》第六章 代谢性疾病 三 小鼠胃排空的评价方法(对乙酰氨基酚法) 李彩娜 申竹芳
1. 一种含有糜蛋白酶抑制肽的胰岛素杂交肽及其应用. 王伟,申竹芳,刘忞之,周思含,李彩娜,申欣,曹慧,雷蕾,杨燕. 申请号:PCT/CN2023/096851,申请日:2023-05-29,申请人:bobapp官方下载
2. 一种含有糜蛋白酶抑制肽的胰岛素杂交肽及其应用. 王伟,申竹芳,刘忞之,申欣,李彩娜,周思含,杨燕. 申请号:202210594279.5,申请日:2022-05-29,申请人:bobapp官方下载
3. 一种含有二硫键且具有抑制丝氨酸蛋白酶活性的多肽、其衍生的杂交肽及其应用. 王伟,申竹芳,刘忞之,李彩娜, 孙素娟,马颖,曹慧,张海婧,杨燕,吴练秋. 申请号:PCT/CN2021/134179,申请日:2021-11-29,申请人:bobapp官方下载
4. 含有二硫键且具有抑制丝氨酸蛋白酶活性的多肽及其应用. 王伟,申竹芳,刘忞之,李彩娜, 孙素娟,马颖,曹慧,张海婧,杨燕,吴练秋. 申请号:202011396904.2,申请日:2020-11-30,申请人:bobapp官方下载
5. 桑枝提取物在制备治疗动物肠道炎症的组合物中的应用. 刘玉玲,申竹芳,刘率男,曹慧,刘志华,刘泉,李彩娜,雷蕾,陈艳敏,朱向阳,邹媛媛. 申请号:202110269805.6,申请日:2021.03.12.,授权日:2022.10.04,申请人:北京五和博澳药业有限公司,广西五和博澳药业有限公司
6. 7-硝基苯并-2-氧杂-1,3-二唑脱氧氨基葡萄糖、其制备方法及应用. 赵哲辉,申竹芳,环奕,雷平生,杨爽,刘率男,李彩娜. 申请号:ZL201811501558.2.,申请日:2018-12-10,申请人:bobapp官方下载
7. 麦芽酚在防治糖尿病周围神经病变中的应用. 申竹芳,刘率男,郭楠,刘泉,许彩民,环奕,李彩娜. 申请号:ZL201710221803.3,申请日:2017-04-07,申请人:bobapp官方下载
8. 一种苯并吡喃类化合物、及其制备方法和药物组合物与用途. 方唯硕,申竹芳,张国宁,环奕,孙得洋,王星,贾文强,孙素娟,李彩娜. 申请号:ZL2017100944011,申请日:2017-02-22,申请人:bobapp官方下载
9. 一类四氢异喹啉化合物及其盐的制备和医药用途. 刘站柱,申竹芳,于然,环奕,贯宝和,彭军,潘璇,刘泉,刘率男,孙素娟,李彩娜,孙兆柱,贾春明,姜茜,王悦,周艳丽。申请号:201611207052.1,授权日:2021-04-13,申请人:bobapp官方下载
10. N-酰基磺酰胺类FBPase抑制剂、其制备方法、药物组合物及用途. 徐柏玲,申竹芳,别建波,穆永钊,陈华龙,刘率男,周洁,李彩娜,曹冉,环奕,孙淑娟. 申请号:201610105864.9.,授权日:2020-10-09,申请人:bobapp官方下载
11. 含五元芳杂环的取代黄嘌呤类化合物及其制备方法和用途. 黄海洪,申竹芳,李刚,袁保昆,环奕,姜茜,林紫云,唐武,刘泉,刘率男,李彩娜. 申请日:2014-11-14,申请号:ZL201410645621.5,授权日:2019-04-09,申请人:bobapp官方下载
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