1996.8-2001.7 北京大学医学部,就读于药理系,获得理学学士学位
2001.8-2006.7 中国协和医科大学,就读于药理系,获得博士学位
2006.8-2010.8 美国NIH从事博士后研究工作
2010.8-2016.9 bobapp官方下载 ,副研究员
2016.9-至今 bobapp官方下载 ,研究员
1. 精神、神经系统疾病的机制研究及相关治疗药物的研发;
2. 炎症免疫相关疾病的机制研究及治疗药物研发;
3. 活性天然产物的生物靶标鉴定与作用机制研究;
4. 肠道微生物在多种疾病进程中的机制及药物研发。
1. Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson’s disease treatment. Shang JM, Ma SR, Zang CX, Bao XQ*, Wang Y*, Zhang D*. Acta Pharmaceutica Sinica B. Accepted. (IF: 11.413)
2. Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-kB pathway through microbiotae-gut-brain axis. Zhao Z, Li FY, Ning JW, Peng R, Shang JM, Liu H, Shang MY, Bao XQ, Zhang D*. Acta Pharmaceutica Sinica B, 2021. (IF: 11.413)
3. Autoimmune polyendocrine syndrome induced by immune checkpoint inhibitors: a systematic review. Zhao Z, Wang X, Bao XQ, Ning J, Shang M, Zhang D*. Cancer Immunol Immunother, 2020. (IF: 6.962)
4. Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy. Liyan Hou, Lin Zhang, Jau-Shyong Hong, Dan Zhang, Jie Zhao, Qingshan Wang. ANTIOXIDANTS & REDOX SIGNALING, 2020. (IF: 8.401)
5. CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis. Wang L, Yang HY, Zang CX, Dong Y, Shang JM, Chen JH, Wang Y, Liu H, Zhang ZH, Bao XQ*, Xu H*, Zhang D*. Neurobiol Dis, 2020. (IF: 5.991)
6. Novel phloroglucinol derivative Compound 21 protects experimental autoimmune encephalomyelitis rats via inhibiting Th1/Th17 cell infiltration. Zhao Z, Bao XQ, Zhang Z, Li F, Liu H, Zhang D*. Brain Behav Immun, 2020. (IF: 7.217)
7. GJ-4 alleviates Aβ25-35-induced memory dysfunction in mice through protecting the neurovascular unit. Zhang Z, Liu H, Zhao Z, Zang C, Ju C, Li F, Wang L, Yang H, Bao X, Yu Y, Yao X, Zhang D*. Biomed Pharmacother, 2020. (IF: 6.529)
8. Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model. L. Hou, F. Sun, R. Huang, W.Sun, Zhang D*, Qingshan Wang*. Redox Biol, 2019. (IF: 11.799)
9. Discovery of coumarinMannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease. Deng Tao, Yue Wang, Xiu-Qi Bao, Bei-Bei Yang, Fan Gao, Lin Wang, Dan Zhang*, Li Li*. European journal of medicinal chemistry, 2019. (IF:6.514)
10. Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. Zhao Z#, Bao XQ, Zhang Z, Liu H, Zhang D*. Sci China Life Sci, 2019. (IF: 6.038)
11. A Novel Synthetic Derivative of Phloroglucinol Inhibits Neuroinflammatory Responses Through Attenuating Kalirin Signaling Pathway in Murine BV2 Microglial Cells. Zang CX, Yang HY, Wang L, Wang Y, Bao XQ, Wang XL, Zhang D*. Mol Neurobiol, 2018. (IF:5.592)
12. Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway. Liyan Hou, Xiuqi bao, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning che, Xuefei Wu, Shao Li, Dan Zhang*, Qingshan Wang*. Redox Biol, 2018. (IF:11.799)
13. NADPH oxidase-derived H2O2 mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease. Hou L, Zhou X, Zhang C, Wang K, Liu X, Che Y, Sun F, Li H, Wang Q*, Zhang D*, Hong JS. Redox Biol, 2017. (IF:11.799)
14. FLZ Attenuates α-Synuclein-Induced Neurotoxicity by Activating Heat Shock Protein 70. Bao XQ, Wang XL, Zhang D*. Mol Neurobiol, 2017. (IF:5.592)
15. A Novel Parkinson's Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway. Wang YD, Bao XQ, Xu S, Yu WW, Cao SN, Hu JP, Li Y, Wang XL, Zhang D*, Yu SS*. J Med Chem, 2016. (IF: 7.446)
16. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Tai W, Ye X, Bao X, Zhao B, Wang X, Zhang D*. Neuropharmacology, 2013. (IF: 5.25)
17. The early events of Alzheimer’s disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits. Ye X, Tai WJ, Zhang D*. Neurobiology of Aging, 2012. (IF: 6.18)
1. 《应用分子药理学》,主编王晓良,中国协和医科大学出版社,2015。
2. 《药理学研究中的新技术与新方法》,主编陈晓光,中国协和医科大学出版社,2014年。
3. 《药理学研究中的新思路与新靶点》,主编陈晓光,中国协和医科大学出版社,2012年。
1. 藏红花色素类组合物在制备用于治疗帕金森症的药物中的应用。姚新生, 张丹, 于洋, 鲍秀琦, 臧彩霞, 盛婵娟。专利号:ZL201810884030.1, 授权日2020.4.28。
2. 藏红花色素类化合物及其用途。姚新生, 于洋, 张丹, 倪阳,鲍秀琦, 李林, 臧彩霞, 高昊,郑远鹏。专利号:ZL201610284974.6。授权日期:2017.12.29。2017255363(澳大利亚),2018-556352(日本),16/097,166(美国),17788553.0(欧专局)。
3. 组合物藏红花色素类活性部位及其用途。姚新生,张丹,于洋,鲍秀琦,倪阳,臧彩霞,高昊,郑远鹏。专利号:ZL201610284549.7。授权日期:2017.03.08;2017255362(澳大利亚),2018-556347(日本),16/097,247(美国),17788552(欧专局)。
4. 含有丁二酸衍生物酯类化合物的凹舌兰提取物在制备用于治疗痴呆症的药物中的用途。张建军、石建功、王亚芳、张丹、高梅、杨永春、黄胜阳。专利号:ZL200710084699.4(中国)。2334524 俄罗斯;855389 韩国;7557089 美国;1582209 欧洲;4880223 日本;2512187 加拿大;237866 印度;IDP0026329 印尼
5. 丁二酸衍生物酯类化合物在制备治疗痴呆症的药物中的用途。张建军,石建功,王亚芳,张丹,高梅,杨永春,黄胜阳。专利号:ZL200380107864.3。
6. 间苯三酚类衍生物及其在治疗神经退行性疾病中的用途。庾石山, 张丹, 王亚丹, 鲍秀琦, 屈晶, 徐嵩, 泰文娇, 武良玉。专利号:ZL201480026162.0,授权日2018.7.20。
7. 咪唑酮-吗啡喃及其制备方法和应用。张丹, 王玉成, 李子强, 鲍秀琦, 白晓光, 张国宁, 王菊仙, 周磊, 李强, 郑远鹏, 臧彩霞。专利号:ZL201610194651.8,授权日期: 2017.05.10。
8. 香豆素曼尼希碱的合成及其在防治神经退行性疾病中的用途。李莉, 王琳, 张丹, 鲍秀琦, 高琦, 臧彩霞, 郑远鹏。申请号:201611177885.8。申请日:2016.11.01。
9. 藏红花色素类组合物在制备治疗或改善抑郁症的药物中的应用。姚新生, 张丹, 于洋, 鲍秀琦, 鲁丹, 臧彩霞, 盛婵娟。申请号:201711020810.3。申请日:2017.10.26。
10. 芬乐胺晶B型、制备方法和其组合物与用途。吕扬,杨世颖,刘耕陶,张丹,鲍秀琦,谢平。申请号:2017105609838。申请日:2017.9.18。
11. 芬乐胺晶G型、制备方法和其组合物与用途。吕扬,杨世颖,刘耕陶,张丹,鲍秀琦,谢平。申请号:2017105607033。申请日:2017.9.18。
1. 2013.6 “教育部新世纪优秀人才” 张丹 教育部
2. 2012.12 “优秀青年科技工作者” 张丹 北京协和医学院
3. 2012.7 “北京市优秀人才” 张丹 北京市委组织部
4. 2012.1 “北京市科技新星” 张丹 北京市科委
5. 2011.12 “协和新星” 张丹 北京协和医学院
6. 2011.12 “青年生物药物奖” 张丹 中国药学会