科研队伍

2007年7月毕业于北京协和医学院,获药理学博士学位。毕业后于bobapp官方下载 国家药物筛选中心工作至今。于2008及2014年分别在加拿大麦吉尔大学健康中心内分泌实验室,美国俄克拉荷马大学进行糖尿病相关博士后研究。

主要研究方向为代谢性疾病药理学与新药发现,主要包括糖尿病及其慢性并发症相关防治药物的药物筛选及评价研究,GPCR相关药物的筛选及机制研究工作,先导化合物的发现及药物作用机理的研究。

1. Lin Yin, Xi Chen, Na Li, Weihua Jia, Nuoqi Wang, Biyu Hou, Li Zhang, Guifen Qiang, Xiuying Yang* and Guanhua Du*. Puerarin ameliorates skeletal muscle wasting and fiber type transformation in STZinduced type 1 diabetic rats. Biomedicine and pharmacotherapy. 2021 Jan;133:110977.
2. Jia WH, Wang NQ, Yin L, Chen X, Hou BY, Wang JH, Qiang GF, Chan CB, Yang XY*, Du GH*. Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice. Biol Sex Differ. 2020 Mar 10;11(1):9.
3. Xu, Chunyang; Hou, Biyu; He, Ping; Ma, Peng; Yang, Xinyu; Yang, Xiuying; Zhang, Li; Qiang, Guifen; Li, Wenlan; Du, Guanhua,Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.Oxid Med Cell Longev, 2020: 6431459.
4. Ping He, Biyu Hou, Yanliang Li , Chunyang Xu, Peng Ma, Sin Man Lam, Victoria Gil , Xinyu Yang, Xiuying Yang, Li Zhang, Guanghou Shui, Junke Song, Guifen Qiang*, Chong Wee Liew, Guanhua Du*. Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation. Biomolecules. 2019;9(9):444.
5. Yang X, Brobst D, Chan WS, MCL T, Herlea-Pana O, Ahuja P, Bi X, Zaw AM, ZSW K, Jia WH, Zhang ZG, Zhang N, SKH C, Cheung WH, JCY L, Griffin TM, Nong W, JHL H, Du GH, Noh HL, Saengnipanthkul S, BKC C, Kim JK, Lee CW, Chan CB, AUID- Oho: Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility. Sci Signal 2019; Aug 13;12(594).
6. Xi Chen 1†, Lin Yin1†, Wei-hua Jia1, Nuo-qi Wang1, Chun-yang Xu2, Bi-yu Hou1, Na Li1, Li Zhang1, Gui-fen Qiang1, Xiu-ying Yang1*and Guan-hua Du1* Chronic Urotensin-II administration improves whole-body glucose tolerance in high-fat diet-fed mice Front. Endocrinol., 12 July 2019 Jul 12;10:453.
7. Shi LL, Jia WH, Zhang L, Xu CY, Chen X, Yin L, Wang NQ, Fang LH, Qiang GF, Yang XY*, Du GH*. Glucose consumption assay discovers coptisine with beneficial effect on diabetic mice. Eur J Pharmacol. 2019 Jul 4;859:172523.
8. Jia WH, Wang NQ, Yin L, Chen X, Hou BY, Qiang GF, Chan CB, Yang XY*, Du GH*: Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice. Biochem Biophys Res Commun 2019 Jun 25;514(2):407-414.
9. Yang XY, MCL T, Hu X, Jia WH, Du GH*, Chan CB*. Interaction of CREB and PGC-1alpha Induces Fibronectin Type III Domain-Containing Protein 5 Expression in C2C12 Myotubes. Cell Physiol Biochem. 2018. 50(4): 1574-1584.
10. Yang XL, Chen F, Yang XY*, Du GH, Xu Y. Low molecular weight heparin does not reduce miscarriages in non-thrombophilic IVF/ICSI-treated women. Acta Obstet Gynecol Scand. 2018 14.
11. John Wood; Chui Ling Tse; Xiuying Yang; Daniel Brobst; Zhixue Liu; Brian Pang; Wing Suen Chan; Aung Moe Zaw; Billy Chow; Keqiang Ye; Chi Wai Lee; Chi Bun Chan* BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle. Metabolism. 2018. 87: 113-122.
12. Xiu-Li YANG , Fei CHEN , Xiu-Ying YANG*, Guan-Hua DU, Yang Xu, Efficacy of low-molecular-weight heparin on the outcomes of IVF/ICSI pregnancy in non-thrombophilic women: a meta-analysis. Acta Obstet Gynecol Scand. 2018. 97(9): 1061-1072.
13. Biyu Hou, Yuerong Zhao, Guifen Qiang, Xiuying Yang, Chunyang Xu, Xi Chen, Chenge Liu, Xiaobo Wang, Li Zhang, and Guanhua D*. Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-β Signaling Pathway Activation in Type 2 Diabetic Rats Oxid Med Cell Longev. 2018 Jul 2; 2018: 4545321.
14. Biyu Hou, Guifen Qiang, Yuerong Zhao, Xiuying Yang, Xi Chen, Yu Yan,Xiaobo Wang, Chenge Liu, Li Zhang, Guanhua Dua* Salvianolic Acid A Protects Against Diabetic Nephropathy through Ameliorating Glomerular Endothelial Dysfunction via Inhibiting AGE-RAGE Signaling. Cell Physiol Biochem 2017;44:2378-2394
15. Hu X, Zhang Q, Zhang M, Yang X, Zeng TS, Zhang JY, Zheng J, Kong W, Min J, Tian SH, Zhu R5, Yuan Z6, Wu C7, Chen LL1 Tannerella forsythia and coating color on the tongue dorsum, and fatty food liking associate with fat accumulation and insulin resistance in adult catch-up fat. Int J Obes (Lond). 2017 Aug 14.
16. MCL Tse, Herlea-Pana O, Brobst D, Yang X, Wood J, Hu X, Liu Z, Lee CW, Zaw AM, BKC Chow, et al. Tumor Necrosis Factor-alpha Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle. Diabetes, 2017,66(7):1858-1870.
17. Qiang G, Kong HW, Fang D, McCann M, Yang X, Du G, Blüher M, Zhu J, Liew CW. The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammation. Nat Commun. 2016 Apr 25;7:11378.

1. 书名:实验药理学。主编:杜冠华。杨秀颖等参编。出版社:高等教育出版社,出版年:2021年3月。ISBN 978-7-04-054780-1
2. 书名:中药材古今研究概评。主编:杜冠华。杨秀颖等参编。出版社:中国医药科技出版社,2018.12。
3. 书名: 《Natural Small Molecule Drugs from Plants》。主编:杜冠华。杨秀颖等参编。出版社:Springer出版社出版。出版日期:2018年12月。
4. 书名:《天然小分子药物-源自于植物的小分子药物》,主编:杜冠华。杨秀颖等参编。出版社:人民卫生出版社。出版日期:2018年6月。
5. 书名:古德曼吉尔曼治疗学的药理学基础(Goodman&Gilman’s The pharmacological Basis of Therapeutics)第12版,主编:Laurence L.Brunton,Brunce A. Chabner,Bjorn C.Knollmann,主审:桑国卫,主译:金有豫 李大魁,人民卫生出版社,出版日期:2016年12月。

1. 葛根素在肌肉萎缩、肌病、肌肉骨骼并发症中的用途。申请号:CN201811247385.6
2. 化合物Palosuran防治骨骼肌萎缩等疾病的用途。申请号:CN110755434A
3. 一种多肽在制备预防或治疗代谢综合征药物中的用途。申请号:CN110038114A
4. 丹酚酸a防治肌肉萎缩、肌病及肌肉骨骼并发症的用途。专利号:CN110038002A
5. 晶V型葛根素在制备预防和/或治疗糖尿病肝脏损伤药物的用途。申请号:CN109662963A
6. 来曲唑晶iii型固体物质及制备方法和其药物组合物与用途 申请号:CN109662963A
7. 来曲唑晶ii型固体物质及制备方法和其药物组合物与用途 申请号:CN109721557A
8. 丹酚酸A对糖尿病血管并发症作用及机制研究。专利号:ZL200710130325.1。证书号第889390。中国
9. 丹酚酸A的α晶型物质、制法以及药物组合物与用途。专利号ZL201210557058.7;证书号:2092570。中国
10. 丹酚酸A的β晶型物质、制法以及药物组合物与用途。专利号ZL2008 1 0223651.1;证书号:1448348号。中国

1. 2017年:“天然产物成药性评价技术创新及应用”,中华医学科技奖三等奖。杜冠华/杨秀颖(第6位)。授奖机构:中华医学会。
2. 2012年:“传统中药丹参的水溶性成分现代药理学研究” 2012年度高等学校科学研究优秀成果奖(科学技术),自然科学奖二等奖,杜冠华/杨秀颖(第5位)。授奖机构:北京协和医学院。
3. 2011年:“天然产物的生物活性评价研究”,中华医学科技奖三等奖。杜冠华/杨秀颖(第10位)。授奖机构:中华医学会。

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