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副研究员

卢诗超

职 称:副研究员

所属科室:合成药物化学研究室

导师类别:

联系方式:lushichao@www.myhortonhome.com

所属重点实验室:

个人简介

卢诗超,山东济南人。2013年毕业于北京协和医学院&bobapp官方下载 ,获得药物化学博士学位。2013至2015年在北京生命科学bobapp官方下载 /北京大学医学部从事博士后研究。目前主要从事基于微量、复杂、活性天然产物的化学合成及新药研发工作。近年来,作为项目负责人主持了国家自然科学基金、北京市自然科学基金、北京市博士后科研活动经费资助项目、中央级公益性科研院所基本科研业务费(创新人才专项)、北京大学天然药物及仿生药物国家重点实验室开放研究课题;参与中国医学科学院医学与健康科技创新工程重大协同创新项目;作为第一作者或通讯作者在Angewandte Chemie International Edition, Green Chemistry, Organic Letters等国际著名期刊发表论文10余篇;以主要完成人获得中国药学会科技进步一等奖;申请发明专利2项。

研究方向

1. 发展合成复杂活性天然产物的新策略和新模式,突破由复杂活性天然产物进行新药创制的关键瓶颈;
2. 发展新型的合成方法学,解决复杂结构的高效构建、药物分子后期精准修饰等问题。

发表论文

1. Jia-Xuan Liu,# Shi-Peng Zhang,# Feng-Sen Sun, Hui Li, Ya-Ling Gong,* Shi-Chao Lu,* Shu Xu,* Asymmetric total synthesis of naphthospironone A. Angew. Chem. Int. Ed. 2023, https://doi.org/10.1002/anie.202303229. (IF = 16.823)
2. Shi-Chao Lu,# Fu-Qiang Wen,# Xi-Dong Guan,* A formal metal-free γ-arylation of 1,3-dicarbonyl compounds via a sequence of isomerization/1,4-addition/[3,3]- sigmatropic rearrangement. Green Chem. 2021, 23, 8964−8968. (IF = 11.034)
3. Hong-Shuang Li,# Shi-Chao Lu,# Zhi-Xin Chang, Liqiang Hao, Fu-Rong Li, Chengcai Xia, Rhodium-catalyzed ring-opening hydroacylation of alkylidenecyclopropanes with chelating aldehydes for the synthesis of γ,δ-unsaturated ketones. Org. Lett. 2020, 22, 5145−5150. (IF = 6.005)
4. Shi-Chao Lu,# Yu-Yan Liang,# Liang Li,# Xiao-Lei Wang, Shi-Peng Zhang, Ya-Ling Gong, Shu Xu,* Synthesis of the tricyclic caged core of palhinine alkaloids based on a non-diels−alder-type strategy. Org. Lett. 2019, 21, 5567−5569. (IF = 6.091)
5. Shi-Chao Lu,# Zhi-Xin Chang,# Yu-Liang Xiao, Hong-Shuang Li,* Regio- and stereoselective synthesis of 2-hydroxymethyl-1,3-enynes by rhodium-catalyzed decarboxylative C−C coupling. Adv. Synth. Catal. 2019, 361, 4831−4836. (IF = 5.851)
6. Jie Wu,# Ran Mu,# Zi-Jie Liu, Shi-Chao Lu,* Gang Liu,* Scalable total synthesis of a mycobactin T analogue utilizing a novel synthetic and protection strategy. Org. Chem. Front. 2019, 6, 2467–2470. (IF = 5.155)
7. Shi-Chao Lu, Hong-Shuang Li,* Ya-Ling Gong, Shi-Peng Zhang, Ji-Guo Zhang, Shu Xu,* Combination of PhI(OAc)2 and 2-nitropropane as the source of methyl radical in room-temperature metal-free oxidative decarboxylation/cyclization: construction of 6-methyl phenanthridines and 1-methyl isoquinolines. J. Org. Chem. 2019, 83, 15415−15425. (IF = 4.745)
8. Shi-Chao Lu, Hong-Shang Li*, Shu Xu, Gui-Yun Duan, Silver-catalyzed C2-selective direct alkylation of heteroarenes with tertiary cycloalkanols. Org. Biomol. Chem. 2017, 15, 324−327. (IF = 3.423)
9. Shi-Chao Lu, Hong-Shuang Li,* Ya-Ling Gong, Xiao-Lei Wang, Fu-Rong Li, Fei Li, Gui-Yun Duan, Shu Xu,* Use of unprotected amino acids in metal-free tandem radical cyclization reactions: divergent synthesis of 6-alkyl/acyl phenanthridines. RSC Adv. 2017, 7, 55891−55896. (IF = 2.936)
10. Shi-Chao Lu,* Yaling Gong, Demin Zhou, Transition metal-free oxidative radical decarboxylation/cyclization for the construction of 6 alkyl/aryl phenanthridines. J. Org. Chem. 2015, 80, 9336−9341. (IF = 4.721)

专著

专利

1. 许述,纪春阳,弓亚玲,卢诗超,张世鹏,一种盐酸普拉克索有关物质的制备方法,2022-05-07,中国,202210488858.1
2. 许述,孙艺菁,张世鹏,弓亚玲,卢诗超,一种派恩加滨的制备方法,2023-02-21,中国,2023101426299

科技奖励

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