职 称：副研究员
所属科室：药物制剂研究室
导师类别：硕士生导师
联系方式：yejun@imm.pumc.edu.cn
所属重点实验室：药物传输技术及新型制剂北京市重点实验室
主要从事肿瘤/免疫靶向纳米递送系统设计及纳米药物研发和应用研究。主持中国博士后科学基金、北京市自然科学基金、北京市科技新星人才项目、北京市科技新星交叉合作课题、中央高校基本科研业务费及企业关键技术项目，参与十二五、十三五国家科技重大专项以及北京市科委重大基金课题。发表SCI论文30余篇，以第一/共一作者在Acta Pharmaceutica Sinica B、Bioactive Materials、Journal for Immunotherapy of Cancer、Journal of Nanobiotechnology等药剂及肿瘤免疫主流期刊发表SCI论文13篇。申请发明专利13项。获2021年度北京市科学技术奖二等奖（前三）、第十七届中国药学会科学技术奖二等奖（前三）、北京市科技新星、“梁周黄于刘”青年科技奖及北京药学年会优秀论文一等奖。担任北京药学会罕见病药学专委会委员，Asian Journal of Pharmaceutical Sciences、Chinese Chemical Letters、Acta Materia Medica杂志青年编委。
[1] J. Ye, L. Li, J. Yin, H. Wang, R. Li, Y. Yang, Y. Guan, X. Xia, Y. Liu, Tumor-targeting intravenous lipid emulsion of paclitaxel: Characteristics, stability, toxicity, and toxicokinetics, J Pharm Anal, 12 (2022) 901-912.
[2] J. Ye, R. Li, J. Cheng, D. Liu, Y. Yang, H. Wang, X. Xu, L. Li, P. Ma, Y. Liu, Comparative Colloidal Stability of Commercial Amphotericin B Nanoformulations Using Dynamic and Static Multiple Light Scattering Techniques, Int. J. Nanomedicine, 17 (2022) 6047-6064.
[3] J. Ye, R. Li, Y. Yang, W. Dong, Y. Wang, H. Wang, T. Sun, L. Li, Q. Shen, C. Qin, X. Xu, H. Liao, Y. Jin, X. Xia, Y. Liu, Comparative colloidal stability, antitumor efficacy, and immunosuppressive effect of commercial paclitaxel nanoformulations, J Nanobiotechnology, 19 (2021) 199.
[4] J. Ye, Y. Gao, M. Ji, Y. Yang, Z. Wang, B. Wang, J. Jin, L. Li, H. Wang, X. Xu, H. Liao, C. Lian, Y. Xu, R. Li, T. Sun, L. Gao, Y. Li, X. Chen, Y. Liu, Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity, J Immunother Cancer, 9 (2021).
[5] J. Ye, Y. Yang, J. Jin, M. Ji, Y. Gao, Y. Feng, H. Wang, X. Chen, Y. Liu, Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma, Bioact. Mater., 5 (2020) 694-708.
[6] W. Dong, J. Ye, J. Zhou, W. Wang, H. Wang, X. Zheng, Y. Yang, X. Xia, Y. Liu, Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein, Acta Pharm. Sin. B, 10 (2020) 1576-1585.
[7] W. Dong, J. Ye, W. Wang, Y. Yang, H. Wang, T. Sun, L. Gao, Y. Liu, Self-Assembled Lecithin/Chitosan Nanoparticles Based on Phospholipid Complex: A Feasible Strategy to Improve Entrapment Efficiency and Transdermal Delivery of Poorly Lipophilic Drug, Int. J. Nanomedicine, 15 (2020) 5629-5643.
[8] J. Ye, Y. Yang, W. Dong, Y. Gao, Y. Meng, H. Wang, L. Li, J. Jin, M. Ji, X. Xia, X. Chen, Y. Jin, Y. Liu, Drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages, Int. J. Nanomedicine, 14 (2019) 3203-3220.
[9] J. Ye, W. Dong, Y. Yang, H. Hao, H. Liao, B. Wang, X. Han, Y. Jin, X. Xia, Y. Liu, Vitamin E-rich Nanoemulsion Enhances the Antitumor Efficacy of Low-Dose Paclitaxel by Driving Th1 Immune Response, Pharm. Res., 34 (2017) 1244-1254.
[10] J. Ye, X. Xia, W. Dong, H. Hao, L. Meng, Y. Yang, R. Wang, Y. Lyu, Y. Liu, Cellular uptake mechanism and comparative evaluation of antineoplastic effects of paclitaxel-cholesterol lipid emulsion on triple-negative and non-triple-negative breast cancer cell lines, Int. J. Nanomedicine, 11 (2016) 4125-4140.
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