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副研究员

田育林

职 称:副研究员

所属科室:合成药物化学研究室

导师类别:硕士生导师

联系方式:tianyulin@www.myhortonhome.com

所属重点实验室:天然药物活性物质与功能国家重点实验室;
活性物质发现与适药化研究北京市重点实验室

个人简介

田育林,博士,副研究员,硕士生导师。2010年本科毕业于沈阳药科大学基础药学理科基地班,2015年在北京协和医学院-bobapp官方下载 取得药物化学博士学位,2015-2018年在纽约州立大学水牛城分校从事博士后研究,2018年进入bobapp官方下载 工作,主要从事药物化学与化学生物学研究,近年来在J. Am. Chem. Soc., Org. Lett., Chem. Commun., Chin. Chem. Lett.等杂志发表论文30多篇,2020年获得北京市科技新星计划资助,2022年获得药物所“梁周黄于刘青年科技奖”三等奖。

研究方向

主要从事药物化学与化学生物学研究,具体包括:
1、新型肿瘤光诊疗探针的开发与应用。
2、基于生物正交反应的新型化学生物学工具的开发与应用。
3、基于结构的药物分子设计、合成与生物活性研究。

发表论文

1. Yu Teng, Rongrong Zhang, Bingbing Yang, Hong Yang, Xiang Li, Dali Yin, Xinchi Feng*, Yulin Tian*, Bioorthogonally-Activated Tetraphenylene-Tetrazine Aggregation-Induced Emission Fluorogenic Probes, J. Mater. Chem. B, 2022, 10(42), 8642–8649. (Inside Front Cover)
2. Yongcheng Wang‡, Yu Teng‡, Hong Yang, Xiang Li, Dali Yin, YulinTian*, Bioorthogonally applicable multicolor fluorogenic naphthalimide–tetrazine probes with aggregation-induced emission characters, Chem. Commun., 2022, 58 (7), 949-952. (Back Cover)
3. Xiang Li‡, Hong Yang‡, Yu Teng, Yongcheng Wang, Dali Yin, Yulin Tian*, A general strategy for in situ assembly of light-up fluorophores via bioorthogonal Suzuki-Miyaura cross-coupling, Chin. Chem. Lett., 2022, 33 (9), 4223-4228.
4. Yu Teng, Hong Yang, Xiang Li,Yongcheng Wang, Dali Yin, YulinTian*, A Bioorthogonal-Activated Fluorescence Turn-On Probe Based on Nitrone-Modified 1,8-Naphthalimide for Live-Cell Imaging, Chin. J. Chem., 2022, 40 (2), 209-214. (Back Cover)
5. Yulin Tian*, Hong Yang, Xiang Li, Yongcheng Wang, Yu Teng, Dali Yin, Design of Nitroso-Modified Naphthylene-Based Fluorophores as Photoactivatable Bioorthogonal Turn-On Probes, Org. Lett., 2021, 23 (9), 3782-3787.
6. Yulin Tian, Ming Fang, Qing Lin*, Intracellular bioorthogonal labeling of glucagon receptor via tetrazine ligation, Bioorg. Med. Chem., 2021, 43, 116256.
7. Hong Yang, Yongcheng Wang, Xiang Li, Yu Teng, Yulin Tian*, A Dansyl Amide N-Oxide Fluorogenic Probe Based on a Bioorthogonal Decaging Reaction, ChemistryOpen, 2021, 10 (10), 1013-1019.
8. Xiang Li, Yongcheng Wang, Hong Yang, Dali Yin, Yulin Tian*, Design of Hydrazone-Modified 1,8-Naphthalimides as Fluorogenic Click Probes Based on Nitrile Imine-Alkyne Cycloaddition, Eur. J. Org. Chem., 2020, 2020 (28), 4296–4300. (Cover Feature)
9. Yulin Tian*‡, Xiang Li‡, Dali Yin, Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling, Chem. Commun., 2019, 55 (85), 12865-12868.
10. Yulin Tian, Qing Lin*, Fitness Factors for Bioorthogonal Chemical Probes, ACS Chem. Biol., 2019, 14 (12), 2489−2496.
11. Yulin Tian, Huafei Zou, Peng An, Zhihong Zhou, Weijun Shen*, Qing Lin*, Design of stapled oxyntomodulin analogs containing functionalized biphenyl cross-linkers, Tetrahedron, 2019, 75 (2), 286-295.
12. Yulin Tian, Qing Lin*, Recent Development of Photo-Cross-Linkers as Tools for Biomedical Research, Chimia, 2018, 72 (11), 758-763.
13. Yulin Tian, Qing Lin*, Genetic encoding of 2-aryl-5-carboxytetrazole-based protein photo-cross-linkers, Chem. Commun., 2018, 54 (35), 4449-4452.
14. Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu, Qing Lin*, Genetically encoded 2-aryl-5-carboxytetrazoles for site-selective protein photo-cross-linking, J. Am. Chem. Soc., 2017, 139 (17), 6078–6081.
15. Yulin Tian, Xiaojian Wang*, Qiong Xiao, Chenbin Sun, Dali Yin*, Synthesis of dihydrobenzoheterocycles through Al(OTf)3-mediated cascade cyclization and ionic hydrogenation, J. Org. Chem., 2014, 79, 9678-9685.
16. Yulin Tian‡, Jing Jin‡, Xiaojian Wang*, Jinping Hu, Qiong Xiao, Wanqi Zhou, Xiaoguang Chen, Dali Yin*, Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design, Eur. J Med. Chem., 2014, 85, 1-15.
17. Yulin Tian, Jianguo Qi, Chenbin Sun, Dali Yin, Xiaojian Wang*, Qiong Xiao, One-pot synthesis of 4-methylisoquinolines via sequential Pd-catalyzed Heck reaction and intramolecular cyclization, Org. Biomol. Chem., 2013, 11, 7262-7266.
18. Yulin Tian, Jing Jin, Xiaojian Wang, Weijuan Han, Gang Li, Wanqi Zhou, Qiong Xiao, Jianguo Qi, Xiaoguang Chen, Dali Yin*, Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor, MedChemComm, 2013, 4, 1267-1274.
19. 田育林, 金晶, 汪小涧, 选择性鞘胺醇-1-磷酸受体1激动剂研究进展, 药学学报, 2012, 47(1), 7-17.

专著

专利

1. 艾托莫德的制备方法,陈思,石泽玉,肖琼,张翔,田育林,尹大力,中国发明专利,2022-06-21,专利号:ZL201811244306.6.
2. 一种艾托莫德的制备方法,陈思,石泽玉,肖琼,张翔,田育林,尹大力,中国发明专利,2022-06-21,专利号:ZL201811244290.9.
3. 普赛莫德的制备方法,石泽玉,陈思,肖琼,张翔,田育林,尹大力,中国发明专利,2022-06-21,专利号:ZL201811244302.8.
4. 一种普赛莫德的制备方法,石泽玉,陈思,肖琼,张翔,田育林,尹大力,中国发明专利,2022-07-19,专利号:ZL201811244291.3.
5. Oxyntomodulin analogs and methods of making and using same, Qing Lin, Avinash Muppidi, Weijun Shen, Huafei Zou, Peter Schultz, Yulin Tian, US Patent, 2018-04-03, No. US9931379B2.
6. 含五元芳杂环的氨基丙二醇类化合物、其制备方法及其医药用途,田育林,汪小涧,金晶,齐建国,周琬琪,陈晓光,尹大力,中国发明专利,2019-04-09, 专利号:ZL201410053130.1.
7. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途,齐建国,汪小涧,金晶,田育林,周琬琪,陈晓光,尹大力,中国发明专利,2018-10-30, 专利号:ZL201410053128.4.

科技奖励

2020年北京市科技新星
2022年bobapp官方下载 “梁周黄于刘青年科技奖”三等奖

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