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研究员

杨立成

职 称:助理教授

所属科室:天然药物活性与功能国家重点实验室

导师类别:博士生导师

联系方式:ylch@www.myhortonhome.com

所属重点实验室:天然药物活性与功能国家重点实验室

个人简介

2006-2010 西南大学 药学专业 学士
2010-2011 中科院上海有机化学bobapp官方下载 研究助理(李昂)
2012-2013 新加坡国立大学 研究助理(赵宇)
2013-2018新加坡国立大学 有机化学 博士(赵宇)
2018-2022 美国Scrippsbobapp官方下载 博士后 (Hans Renata)

研究方向

课题组将致力于化学酶法的合成研究,包括酶的发现与改造,探索和优化酶的新颖反应性,开发新型的生物酶用于化学合成;结合酶催化和化学合成制备重要化学中间体,推向活性天然产物和药物分子的合成,为药物开发提供充足的候选分子库。

发表论文

1. “Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution” Yang, L.-C.; Deng, H.; Renata, H. Org. Process Res. Dev. 2022, 26, 1925-1943.
2. “Diastereoselective Synthesis of β-Branched α-Amino Acids via Biocatalytic Dynamic Kinetic Resolution,” Li, F.;# Yang, L.-C.;# Zhang, J.; Chen, J. S.; Renata, H.* Angew. Chem., Int. Ed. 2021, 60, 17680-17685. (Co-first author; featured in Synfacts)
3. “Stereoselective Access to [5.5.0] and [4.4.1] Bicyclic Compounds through Pd-Catalysed Divergent Higher-Order Cycloadditions,” Yang L.-C.;# Wang, Y.-N.;# Liu, R.; Luo, Y.; Ng, X. Q.; Yang, B.; Rong, Z.-Q.; Lan, Y.;* Shao, Z.;* Zhao, Y.* Nat. Chem. 2020, 12, 860-868.
4. “Pd-Titanium Relay Catalysis Enables Switch of Alkoxide-π-Allyl to Dienolate Reactivity for Spiro-Heterocycle Synthesis," Yang, L.-C.; Tan, Z. Y.; Rong, Z.-Q.; Liu, R.; Wang, Y.-N.; Zhao, Y.* Angew. Chem. Int. Ed. 2018, 57, 7860-7864. (Featured in Synfacts)
5. “Pd-Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten-Membered Heterocycles,” Wang, Y.-N.;# Yang L.-C.;# Rong, Z.-Q.; Liu, T.-L.; Liu, R.; Zhao, Y.* Angew. Chem., Int. Ed. 2018, 57, 1596-1600. (Co-first author; featured in Synfacts)
6. “Nine-membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” Rong, Z.-Q.;# Yang, L.-C.;# Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.;* Zhao, Y.* J. Am. Chem. Soc. 2017, 139, 15304-15307. (Co-first author; featured in Synfacts)
7. “Construction of Nine-Membered Heterocycles through Palladium-Catalyzed Formal [5+4] Cycloaddition,” Yang, L.-C.;# Rong, Z.-Q.;# Wang, Y.-N.; Tan, Z. Y.; Wang, M.; Zhao, Y.* Angew. Chem. Int. Ed. 2017, 56, 2927-2931. (Featured in Synfacts; ESI highly cited paper)
8. “Acid-Assisted Ru-Catalyzed Enantioselective Amination of 1,2-Diols through Borrowing Hydrogen,” Yang, L.-C.; Wang, Y.-N.; Zhang, Y.;* Zhao, Y.* ACS Catal., 2017, 7, 93-97. (Featured in Synfacts)
9. “Ligand Coordination/Dissociation-Induced Divergent Allylic Alkylations Using Alkynes," Huang, Y.; Ma, C.; Liu, S.; Yang, L.-C.; Lan, Y.;* Zhao, Y.* Chem. 2021, 7, 812-826.
10. “Divergent Synthesis of Complex ent-Kauranes, ent-Atisanes and ent-Trachylobanes via a Hybrid Oxidative Approach,” Zhang, X.; King-Smith, E.; Dong, L.-B.; Yang, L.-C.; Rudolf, J. D.; Shen, B.; Renata, H.* Science 2020, 369, 799-806.
11. “Dynamic Kinetic Asymmetric Amination of Alcohols Assisted by Microwave: Stereo-convergent Access to Tetralin- and Indane-Derived Chiral Amines," Rong, Z.-Q.; Yu, Z.; Weng, C.; Yang, L.-C.; Lu, S.; Lan, Y.;* Zhao, Y.* ACS Catal. 2020, 10, 9464-9475.
12. “Practical, Highly Stereoselective Allyl- and Crotylsilylation of Aldehydes Catalyzed by Readily Available Cinchona Alkaloid Amide," Huang, Y.; Yang, L.; Shao, P.; Zhao, Y.* Chem. Sci. 2013, 4, 3275-3281.

专著

专利

科技奖励

国家优秀自费留学奖学金(2018)

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