1. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Xueju Wei1, Yue Huo1, Jingnan Pi1, Yufeng Gao1, Shuan Rao1, Manman He1, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, and Jia Yu*. Nature cell biology. 2022
2. Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies. Jingbo Zhang1, Huimin Jiang1, Songwen Lin1, Deyu Wu, Hua Tian, Lin Jiang, Yiman Cui, Jing Jin*, Xiaoguang Chen*, Heng Xu*. Journal of medicinal chemistry. 2022
3. Design, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors. MinjianYang1, Huimin Jiang1, Zhuo Yang, Xue Liu, Hanyu Sun, Mengyao Hao, Jinping Hu*, Xiaoguang Chen*, JingJin*;Wangxiao Jian*. European journal of medicinal chemistry. 2022
4. S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung. Mengyao Hao1, Rong Fu1, Jun Tai, Zhenhuan Tian, Xia Yuan, Yang Chen, Mingjin Wang, Huimin Jiang, Ming Ji, Fangfang Lai, Nina Xue, Liping Bai, Yizhun Zhu, Xiaoxi Lv*, Xiaoguang Chen*, Jing Jin*. Acta Pharmaceutica Sinica B. 2022
5. SymMap database and TMNP algorithm reveal Huanggui Tongqiao granules for Allergic rhinitis through IFN-mediated neuroimmuno-modulation. Yaru Kong1, Mengyao Hao, Aiping Chen, Tianxing Yi, Ke Yang, Peng Li, Yi Wang, Pengfei Li, Xinbei Jia, Han Qin, Yuwei Qi, Jie Ji, Jing Jin*, Qian Hua*, Jun Tai*. Pharmacological research. 2022
6. Chlorogenic Acid Relieves the Lupus Erythematosus-like Skin Lesions and Arthritis in MRL/lpr Mice. Ruxuan Wang1, Xiaoyi Yang1, Shen You, Mengyao Hao, Jianguang Li, Xiaoguang Chen*, Jing Jin*. Pharmaceuticals (Basel). 2022
7. Ypd-30, a prodrug of ypd-29b, is an oral small-molecule inhibitor targeting pd-l1 for the treatment of human cancer. Fangfang Lai1, Ming Ji1, Lei Huang, Yunchen Wang, Nina Xue, Tingting Du, Kai Dong, Xiaoqing Yao, Jing Jin*, Zhiqiang Feng*, Xiaoguang Chen*. Acta pharmaceutica Sinica B vol. 2022
8. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. Yi Dong1, Rong Fu1, Jiajing Chen, Kehui Zhang, Ming Ji, Mingjin Wang, Huimin Jiang, Wei Ye, Jinping Hu, Yan Li, Jing Jin*, Xiaoguang Chen*, Heng Xu*. Journal of Medicinal Chemistry. 2021
9. Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors. Yan Sun1, Rong Fu1, Songwen Lin, Jingbo Zhang, Ming Ji, Yan Zhang, Deyu Wu, Kehui Zhang, Hua Tian, Mingyi Zhang, Li Sheng, Yan Li, Jing Jin*, Xiaoguang Chen*, Heng Xu*. Bioorganic & Medicinal Chemistry. 2021
10. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation.Tao Liu1, Qinglv Wei1, Jing Jin1, Qingya Luo, Yi Liu, Yu Yang, Chunming Cheng, Lanfang Li, Jingnan Pi, Yanmin Si, Hualiang Xiao, Li Li, Shuan Rao, Fang Wang, Jianhua Yu, Jia Yu*, Dongling Zou*, and Ping Yi*. Nucleic Acids Research. 2020
11. Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. Qiumu Xi1, Mingjin Wang1, Wenqiang Jia, Mingjian Yang, Jinping Hu, Jing Jin*, Xiaoguang Chen*, Dali Yin, and Xiaojian Wang*. J Med Chem. 2020
12. A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal models. Jing Jin1, Nina Xue1, Yuan Liu, Rong Fu, Mingjin Wang, Ming Ji, Fangfang Lai, Jinping Hu, Xiaojian Wang, Qiong Xiao, Xiaoying Zhang, Dali Yin,Liping Bai, Xiaoguang Chen*, Shuan Rao*. Acta Pharmaceutica Sinica B .2020
13. Songwen Lin1, Jing Jin1, Ying Liu1, Hua Tian, Yan Zhang, Rong Fu, Jingbo Zhang, Mingjin Discovery of 4-Methylquinazoline based PI3K inhibitors for the potential treatment of idiopathic pulmonary fibrosis. Wang, Tingting Du, Ming Ji, Deyu Wu, Kehui Zhang, Li Sheng, Yan Li, Xiaoguang Chen*, and Heng Xu*.J Med Chem. 2019
14. Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer.Nina Xue1, Fangfang Lai1, Tingting Du, Ming Ji, Di Liu, Chunhong Yan, Sen Zhang, Xiaoming Yu, Jing Jin* and Xiaoguang Chen*. Cell Mol Life Sci. 2019
15. Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis. Jing Jin1, Ming Ji1, Rong Fu, Mingjin Wang, Nina Xue, Qiong Xiao, Jinping Hu, Xiaojian Wang, Fangfang Lai*, Dali Yin*, Xiaoguang Chen*. Frontiers in pharmacology. 2019
16. The Development of a Biotinylated NAD+-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay.Ming Ji1, Liyuan Wang1, Nina Xue, Fangfang Lai, Sen Zhang, Jing Jin* and Xiaoguang Chen*. SLAS Discovery. 2018
17. Validating a Selective S1P1 Receptor Modulator Syl930 for Psoriasis Treatment. Ming Ji, Nina Xue, Fangfang Lai, Xiaoying Zhang, Sen Zhang, Yuchen Wang, Jing Jin* and Xiaoguang Chen*. Biol. Pharm. Bull. 2018
18. CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression. Ming Ji, Liyuan Wang, Ju Chen, Nina Xue, Chunyang Wang, Fangfang Lai, Rubing Wang, Shishan Yu, Jing Jin* and Xiaoguang Chen*. Onco Targets Ther. 2018
19. Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors. Guonan Cui1, Jing Jin1, Hualong Chen, Ran Cao, Xiaoguang Chen*, Bailing Xu*. Bioorganic & Medicinal Chemistry. 2018