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导师介绍

再帕尔·阿不力孜

职 称:研究员

所属科室:药物分析研究室

导师类别:博士生导师

联系方式:zeper@www.myhortonhome.com

所属重点实验室:天然药物活性物质与功能国家重点实验室

个人简介

再帕尔·阿不力孜,男,1961年出生,维吾尔族,理学博士。现任中央民族大学副校长、教授;中国医学科学院/北京协和医学院bobapp官方中国有限公司 研究员、博士生导师,药物分析研究室主任,天然药物活性物质与功能国家重点实验室副主任,北京协和医学院药物分析学系主任。北京市政协常委,国务院学位委员会第七届药学学科评议组成员,第七届教育部科学技术委员会委员,中国分析测试协会副理事长,中国物理学会质谱分会副理事长,中国化学会质谱分析专业委员会副主任委员。“新世纪百千万人才工程”国家级人选,享受国务院政府特殊津贴专家,国家民委领军人才,曾担任“863”计划项目首席专家,现担任国家重点研发计划项目负责人等。

研究方向

质谱分析新方法、新技术研究及其在生物医药中的应用

科研成果

发表论文

1) Zhigang Luo†, Jiuming He†, Yi Chen, Jingjing He, Tao Gong, Fei Tang, Xiaohao Wang, Ruiping Zhang, Lan Huang, Lianfeng Zhang, Haining Lv, Shuanggang Ma, Zhaodi Fu, Xiaoguang Chen, Shishan Yu, Zeper Abliz*. Air Flow-Assisted Ionization Imaging Mass Spectrometry Method for Easy Whole-Body Molecular Imaging under Ambient Conditions. Anal Chem, 2013, 85(5): 2977-2982.
2) Wei Yang, Yanhua Chen, Cong Xi, Ruiping Zhang, Yongmei Song, Qimin Zhan, Nan Bi, Zeper Abliz*. Liquid chromatography-tandem mass spectrometry-based plasma metabonomics delineate the effect of metabolites' stability on reliability of potential biomarkers. Anal Chem, 2013, 85(5): 2606-2610.
3) Jing Xu†, Yanhua Chen†, Ruiping Zhang, Yongmei Song, Jianzhong Cao, Nan Bi, Jingbo Wang, Jiuming He, Jinfa Bai, Lijia Dong, Lvhua Wang, Qimin Zhan, Zeper Abliz*. Global and Targeted Metabolomics of Esophageal Squamous Cell Carcinoma Discovers Potential Diagnostic and Therapeutic Biomarkers. Mol Cell Proteomics, 2013, 12(5): 1306-1318.
4) Yanhua Chen, Jing Xu, Ruiping Zhang, Guoqing Shen, Yongmei Song, Jianghao Sun, Jiuming He, Qimin Zhan, Zeper Abliz*. Assessment of Data Pre-processing Methods for LC-MS/MS-based Metabolomics of Uterine Cervix Cancer. Analyst, 2013, 138(9): 2669-2677.
5) Yanhua Chen, Guoqing Shen, Ruiping Zhang, Jiuming He, Yi Zhang, Jing Xu, Wei Yang, Xiaoguang Chen, Yongmei Song, Zeper Abliz*. Combination of Injection Volume Calibration by Creatinine and MS Signals’ Normalization to Overcome Urine Variability in LC-MS-Based Metabolomics Studies. Anal Chem, 2013, 85(16): 7659-7665.
6) He Tian, Jinfa Bai, Zhuoling An, Yanhua Chen, Ruiping Zhang, Jiuming He, Xiaofeng Bi, Yongmei Song, Zeper Abliz*. Plasma metabolome analysis by integrated ionization rapidresolution liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom, 2013, 27(18): 2071-2080.
7) Zhonghua Wang, Baoxin Zhao, Xuhui Liu, Yajie Zheng, Junxia Wang, Ruiping Zhang*, Zeper Abliz. A rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of S-phenylmercapturic acid in human urine. Anal Methods, 2013, 5(21): 6081-6085.
8) 习聪, 陈艳华, 杨维, 张瑞萍*, 贺玖明, 张化冰, 肖新华, 再帕尔•阿不力孜. 脂质组学血清样品处理方法及其快速高分辨液相色谱-质谱分析. 分析化学, 2013, 41(9): 1308-1314.
9) 臧清策, 何菁菁, 白进发, 郑亚杰, 张瑞萍, 李铁钢, 王中华, 贺玖明*, 再帕尔•阿不力孜. 快速筛查中药注射液中有害物质5-羟甲基糠醛的LC-MS/MS方法及其质量评价研究. 药学学报, 2013, 48(11): 1707-1709.
10) Yajie Zheng, Jiuming He, Ruiping Zhang, Yucheng Wang, Juxian Wang, Huiqing Wang, Yan Wu, Wenyi He, Zeper Abliz*. An integrated approach for detection and characterization of the trace impurities in levofloxacin using liquid chromatography–tandem mass spectrometry. Rapid Commun Mass Spectrom, 2014, 28(10): 1164-1174.
11) 罗志刚, 贺玖明, 刘月英, 李铁钢, 何菁菁, 张四纯, 张新荣, 再帕尔·阿不力孜*. 质谱成像分析技术, 方法与应用进展. 中国科学: 化学, 2014, 44(5): 795-800. 综述
12) Yan Gao, Ruiping Zhang, Jinfa Bai, Xuejun Xia, Yanhua Chen, Zhigang Luo, Jing Xu, Yang Gao, Yuling Liu, Jiuming He*, Zeper Abliz*. Targeted Data-Independent Acquisition and Mining Strategy for Trace Drug Metabolite Identification Using Liquid Chromatography Coupled with Tandem Mass Spectrometry. Anal Chem, 2015, 87(15): 7535-7539.
13) Jingjing He†, Zhigang Luo†, Lan Huang, Jiuming He, Yi Chen, Xianfang Rong, Shaobo Jia, Fei Tang, Xiaohao Wang, Ruiping Zhang, Jianjun Zhang, Jiangong Shi*, Zeper Abliz*. Ambient Mass Spectrometry Imaging Metabolomics Method Provides Novel Insights into the Action Mechanism of Drug Candidates. Anal Chem, 2015, 87(10): 5372-5379.
14) Tiegang Li†, Jiuming He†, Xinxin Mao, Ying Bi, Zhigang Luo, Chengan Guo, Fei Tang, Xin Xu, Xiaohao Wang, Mingrong Wang, Jie Chen*, Zeper Abliz*. In situ biomarker discovery and label-free molecular histopathological diagnosis of lung cancer by ambient mass spectrometry imaging. Sci Rep, 2015, 5: 14089.
15) Zhonghua Wang, Yajie Zheng, Baoxin Zhao, Yanping Zhang, Zhe Liu, Jing Xu, Yanhua Chen, Zhao Yang, Fenfen Wang, Huiqing Wang, Jiuming He, Ruiping Zhang*, Zeper Abliz*. Human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach. J Proteome Res, 2015, 14(6): 2583-2593.
16) Qingce Zang, Yang Liu, Jiuming He, Xiaofei Yue, Ruiping Zhang, Renzhi Wang, Zeper Abliz*. A sensitive and rapid HPLC–MS/MS method for the quantitative determination of trace amount of bromocriptine in small clinical prolactinoma tissue. Journal of Chromatography B, 2015, 989: 91-97.
17) 贺玖明, 郑亚杰, 高杨, 张瑞萍, 王惠青, 再帕尔·阿不力孜*. 液相色谱能量相关二级质谱快速鉴定药物氧化降解产物. 分析化学, 2015, 43(4): 479-483.
18) 杨芬, 贺玖明, 张瑞萍, 再帕尔·阿不力孜*. 快原子轰击离子化质谱研究酚类化合物抗氧化作用. 分析化学, 2015, 43(2): 233-238.
19) Xinxin Mao†, Jiuming He†, Tiegang Li, Zhaohui Lu, Jian Sun, Yunxiao Meng, Zeper Abliz*, Jie Chen*. Application of imaging mass spectrometry for the molecular diagnosis of human breast tumors. Sci Rep, 2016, 6: 21043.
20) Yanhua Chen†, Jing Xu†, Ruiping Zhang, Zeper Abliz*. Methods used to increase the comprehensive coverage of urinary and plasma metabolomes by MS. Bioanalysis, 2016, 8(9): 981-997.
21) Huiqing Wang, Jing Xu, Yanhua Chen, Ruiping Zhang, Jiuming He, Zhonghua Wang, Qingce Zang, Jinfeng Wei, Xiaowei Song, Zeper Abliz*. Optimization and Evaluation Strategy of Esophageal Tissue Preparation Protocols for Metabolomics by LC–MS. Anal Chem, 2016, 88(7): 3459-3464.
22) Jing Xu, Yanhua Chen, Ruiping Zhang, Jiuming He, Yongmei Song, Jingbo Wang, Huiqing Wang, Luhua Wang, Qimin Zhan, Zeper Abliz*. Global metabolomics reveals potential urinary biomarkers of esophageal squamous cell carcinoma for diagnosis and staging. Sci Rep, 2016, 6: 35010.
23) 罗志刚, 何菁菁, 贺玖明, 白进发, 再帕尔·阿不力孜*. 高分辨质谱直接分析食用油中脂肪酸甘油酯. 质谱学报, 2016, 37(5): 393-400.
24) 罗志刚, 贺玖明, 李铁钢, 周帜, 黄罗娇, 张瑞萍, 马双刚, 庾石山, 再帕尔·阿不力孜*. 基于高分辨质谱技术的整体动物体内药物成像分析新方法研究. 质谱学报, 2017, 38(4): 85-92.
25) 罗志刚, 何菁菁, 贺玖明, 再帕尔·阿不力孜*. 敞开式质谱成像方法的组织样品稳定性研究. 分析测试学报, 2017, 36(2): 178-183.
26) Xiaowei Song, Zhigang Luo, Xin Li, Tiegang Li, Zhonghua Wang, Chenglong Sun, Luojiao Huang, Ping Xie, Xiaoyu Liu, Jiuming He*, Zeper Abliz*. In situ Hydrogel Conditioning of Tissue Samples to Enhance the Drug’s Sensitivity in Ambient Mass Spectrometry Imaging. Anal Chem, 2017, 89(12): 6318-6323.
27) Yanhua Chen†, Zhi Zhou†, Wei Yang, Nan Bi, Jing Xu, Jiuming He, Ruiping Zhang, Lvhua Wang, Zeper Abliz*. Development of a Data-Independent Targeted Metabolomics Method for Relative Quantification Using Liquid Chromatography Coupled with Tandem Mass Spectrometry. Anal Chem, 2017, 89(13): 6954-6962.
28) Zhi Zhou, Yanhua Chen*, Jiuming He, Jing Xu, Ruiping Zhang, Yan Mao, Zeper Abliz. Systematic evaluation of serum and plasma collection on the endogenous metabolome. Bioanalysis, 2017, 9(3): 239-250.
29) Rui Zhang†, Peishan Hu†, Qingce Zang, Xiaofei Yue, Zhi Zhou, Xiaoyu Xu, Jing Xu, Shanshan Li, Yanhua Chen, Boqin Qiang, Xiaozhong Peng, Wei Han*, Ruiping Zhang*, Zeper Abliz. LC-MS-based metabolomics reveals metabolic signatures related to glioma stem-like cell selfrenewal and differentiation. RSC Adv, 2017, 7(39): 24221-24232.
30) Qingce Zang, Yang Gao, Luojiao Huang, Jiuming He, Sheng Lin, Hongtao Jin, Ruiping Zhang, Zeper Abliz*. Rapid and sensitive liquid chromatography–tandem mass spectrometric method for the quantitative determination of potentially harmful substance 5, 5’-oxydimethylenebis (2-4 furfural) in traditional Chinese medicine injections. Acta Pharmaceutica Sinica B, 2018, 8(2): 235-241.
31) Jiuming He†, Luojiao Huang†, Runtao Tian, Tiegang Li, Chenglong Sun, Xiaowei Song, Yiwei Lv, Zhigang Luo, Xin Li, Zeper Abliz*. MassImager: A software for interactive and in-depth analysis of mass spectrometry imaging data. Anal Chim Acta, 2018, 1015: 50-57.
32) Chenglong Sun, Jiuming He, HongboWu, Xiaowei Song, Jiangshuo Li, Luojiao Huang, Xiaoyu Xu, Manjiangcuo Wang, Ruiping Zhang, Zeper Abliz*. A rapid and sensitive UPLC–MS/MS method for quantitative determination of arformoterol in rat plasma, lung and trachea tissues. Chin Chem Lett, 2018, https://doi.org/10.1016/j.cclet.2018.01.015.
33) Zhigang Luo, Jingjing He, Jiuming He, Lan Huang, Xiaowei Song, Xin Li, Zeper Abliz*. Quantitative analysis of drug distribution by ambient mass spectrometry imaging method with signal extinction normalization strategy and inkjet-printing technology. Talanta, 2018, 179: 230-237.
34) 王中华, 何秉淑, 孙成龙, 宋肖炜, 贺玖明, 张瑞萍, 再帕尔·阿不力孜*. 基于空气动力辅助离子化鄄超高分辨质谱成像技术的大鼠肾脏组织中多种类代谢物的分布研究. 分析化学, 2018, 46(3): 406-412.

专著

专利

授权专利4

1)再帕尔·阿不力孜,唐飞,贺玖明,陈一,罗志刚,郭成安,毕滢,李铁钢,一种用于生物组织质谱成像的离子传输装置,2015.12.23,中国,ZL 201520580709.3

2)唐飞,师玉鹏,王晓浩,再帕尔·阿不力孜,陈一,贺玖明,一种离子源温控加热装置,2015.08.12,中国,ZL201210348043.X

3)唐飞,王晓浩,再帕尔·阿不力孜,陈一,贺玖明,质谱成像平台装置及其控制方法,2014.03.05,中国,ZL201210055424.9

4)再帕尔·阿不力孜,贺玖明,唐飞,赵猛,王晓浩,敞开式喷雾场解吸离子化方法及离子化装置,2012.07.25,中国,ZL200710303649.0

申请专利5

1)再帕尔·阿不力孜,宋肖炜,贺玖明,罗志刚,孙成龙,厉欣,黄罗娇,张瑞萍,一种体内药物的离子强度虚拟校正和定量质谱成像分析方法,申请日2018.01.15,申请号201810034611.6

2)再帕尔 阿不力孜,陈艳华,岳小飞,周帜,徐婧,张瑞萍,一种基于LC-MS/MS技术的筛查癌症生物标志物的靶向定性定量代谢组学分析方法,申请日2017.11.27,申请号:201711024620.9

3)再帕尔·阿不力孜,宋肖炜,贺玖明,厉欣,孙成龙,罗志刚,李铁钢,黄罗娇,一种模拟生物组织薄片、其制备方法及其应用与装置,申请日2017.04.07,申请号201710222588.9

4)再帕尔·阿不力孜,宋肖炜,贺玖明,孙成龙,厉欣,罗志刚,黄罗娇,固相水凝胶在质谱成像中的应用,申请日2016.12.26,申请号201611213742.8

5)臧清策,再帕尔·阿不力孜,贺玖明,靳洪涛,林铌,高杨,张瑞萍,林生,王爱平,林琳,范潇予,一种5-羟甲基糠醛二聚体在药品安全性控制中的应用,申请日2016.04.11,申请号201610219198.1

6)贺玖明,高妍,再帕尔·阿不力孜,张瑞萍,陈艳华,一种目标非依赖型数据采集和信息挖掘方法及其应用,申请日2015.02.11,申请号201510074779.6.

软件著作权2

1)刘艾林,再帕尔阿不力孜,张金兰,陈艳华,李岩,孙华,王映红,贺文义。国家代谢组学数据库(简称:代谢组学数据库),2.0版本。证书号:软著登字第1381900号。开发完成日期:20151212日。

2)贺玖明,再帕尔·阿不力孜,李铁钢,罗志刚,黄罗娇,宋肖炜,孙成龙,厉欣,张瑞萍。质谱成像代谢组学数据处理软件系统[简称:MSI]。登记号:2017SR563585。著作权人:bobapp官方下载

科技奖励

1) 2009年北京市科学技术奖三等奖,“人红细胞降压物质及其结构鉴定”,文允镒,胡玉芳,再帕尔•阿不力孜等(第3完成人)。
2) 2010年教育部高等学校科技成果奖自然科学奖一等奖,“中国若干重要有毒药用植物活性成分研究”,庾石山,陈晓光,再帕尔•阿不力孜等(第3完成人)。
3) 2010年北京市科学技术奖二等奖,“功能分子结构及药物复杂体系多组分的质谱分析新方法”,再帕尔•阿不力孜,贺玖明,张瑞萍,石建功,乔晋萍,阿布拉江•克依木,项赟,庾石山,耿平,李斌等(第1完成人)。
4) 2010年度药明康德生命化学研究奖三等奖,“天然产物分析鉴别及其复杂体系活性组分群的高效、快速分析方法研究”, 再帕尔•阿不力孜。
5) 2011年中华医学科技奖三等奖,“药物复杂体系多组分及功能分子结构表征的质谱分析新方法”,再帕尔•阿不力孜,贺玖明,张瑞萍,石建功,乔晋萍,阿布拉江•克依木,项赟,庾石山,耿平,李斌等(第1完成人)。
6) 2014年度中国分析测试协会科学技术奖一等奖,再帕尔•阿不力孜,陈艳华,徐婧,罗志刚,张瑞萍,贺玖明,杨维,宋咏梅,唐飞,黄江,田亚平,田鹤(第1完成人)。

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