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研究员

刘陆平

职 称:助理教授

所属科室:天然药物活性物质与功能国家重点实验室

导师类别:博士生导师

联系方式:lpliu@www.myhortonhome.com

所属重点实验室:天然药物活性物质与功能国家重点实验室

个人简介

刘陆平 女,研究员,博士生导师。2022年7月,全职入职中国医学科学院北京协和医学院bobapp官方中国有限公司 ,任课题组长。课题组致力于化学和生物学前沿交叉研究,关注新型生物化学技术研发和新药创制。迄今在 Nature Chemistry(2篇)、J. Am. Chem. Soc.、Angew. Chem. 等国际知名刊物上发表论文20余篇,获国际发明专利授权 3 项。荣获Thieme Chemistry Journals Award 2023,2022年北京市科技新星计划创新新星,留德华人化学化工学会青年化学奖 (一等奖),国家优秀自费留学生奖学金等多项荣誉。2006至2013年就读于兰州大学,师从王锐院士,获生物技术学士学位和生物化学与分子生物学硕士学位。2013年8月,前往德国马克斯–普朗克煤炭bobapp官方下载 (Max Planck Institute for Coal Research)攻读有机化学博士学位,师从Benjamin List教授(2021 诺贝尔化学奖得主),进行有机不对称催化合成相关研究。2018年1月加入美国加州大学圣地亚哥分校(UCSD)Neal Devaraj教授课题组,从事化学生物学的博士后研究。

研究方向

刘陆平课题组关注基础有机化学和现代生物医药技术的融合,主要研究方向包括:
1. 精准调控生物正交化学技术的研发与应用;
2. 生物相容性催化化学;
3. 生物药物和分子探针。

发表论文

1. Luping Liu; Dongyang Zhang; Mai Johnson; Neal K. Devaraj*. Light-activated tetrazines enable precision live-cell bioorthogonal chemistry, Nature Chemistry, 2022, 14: 1078–1085.
2. Dongyang Zhang; Luping Liu; Shuaijiang Jin; Ember Tota; Zijie Li; Xijun Piao; Xuan Zhang; Xiang-Dong Fu; Neal K. Devaraj*. Site-Specific and Enzymatic Cross-Linking of sgRNA Enables Wavelength-Selectable Photoactivated Control of CRISPR Gene Editing, Journal of the American Chemical Society, 2022, 144(10): 4487–4495.
3. Luping Liu; Yike Zou; Ahanjit Bhattacharya; Dongyang Zhang; Susan Q. Lang; K. N. Houk; Neal K. Devaraj*. Enzyme-free synthesis of natural phospholipids in water, Nature Chemistry, 2020, 12: 1029–1034.
4. Luping Liu; Hyejin Kim; Youwei Xie; Christophe Farés; Philip S. J. Kaib; Richard Goddard; Benjamin List*. Catalytic Asymmetric [4+2] Cycloaddition of Dienes with Aldehydes, Journal of the American Chemical Society, 2017, 139(39): 13656–13659.
5. Luping Liu#; Philip S. J. Kaib#; AurélienTap; Benjamin List*. A General Catalytic Asymmetric Prins Cyclization, Journal of the American Chemical Society, 2016, 138(34): 10822–10825.
6. Sayantani Das#; Luping Liu#; Yiying Zheng; M. Wasim Alachraf; Walter Thiel*; Chandra Kanta De*; Benjamin List*. Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet-Spengler Reaction, Journal of the American Chemical Society, 2016, 138(30): 9429–9432.
7. Luping Liu; Markus Leutzsch; Yiying Zheng; M. Wasim Alachraf; Walter Thiel; Benjamin List*. Confined Acid-Catalyzed Asymmetric Carbonyl-Ene Cyclization, Journal of the American Chemical Society, 2015, 137(41): 13268–13271.
8. Luping Liu; Dekui Zhang; Panpan Zhang; Xianxing Jiang*; Rui Wang*. Catalytic highly asymmetric 1,5(6)-selective cyclization reaction of α-hydroxyimino cyclic ketones: direct approach to ring-fused hydroxyimino dihydropyrans, Organic and Biomolecular Chemistry, 2013, 11: 5222–5225.
9. Xianxing Jiang*; Luping Liu; Panpan Zhang; Yuan Zhong; Rui Wang*. Catalytic Asymmetric β,γ Activation of α,β-Unsaturated γ-Butyrolactams: Direct Approach to β,γ-Functionalized Dihydropyranopyrrolidin-2-ones, Angewandte Chemie International Edition, 2013, 52(43): 11329–11333.
10. Luping Liu; Yuan Zhong; Panpan Zhang; Xianxing Jiang*; Rui Wang*. The Core Scaffold-Inspired Stereoselective Synthesis of Spiropyrazolones via an Organocatalytic Michael/Cyclization Sequence, Journal of Organic Chemistry, 2012, 77(22): 10228–10234.

专著

专利

1. Light-controlled Bioorthogonal Tetrazine Ligation, Neal K. Devaraj; Luping Liu; 2022-4-7, WIPO, WO2022/072374 A1.

科技奖励

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